The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages. - Institut Pasteur Access content directly
Journal Articles Journal of Immunology Year : 2006

The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages.

Abstract

We previously reported that the stimulation of monocyte-derived macrophages (MDM) by plate-bound i.v. Igs inhibits HIV-1 replication. In this study, we show that IgG immune complexes also suppress HIV-1 replication in MDMs and that activating receptors for the Fc portion of IgG-FcgammaRI, FcgammaRIIA, and FcgammaRIII-are responsible for the inhibition. MDM stimulation through FcgammaRs induces activation signals and the secretion of HIV-1 modulatory cytokines, such as M-CSF, TNF-alpha, and macrophage-derived chemokine. However, none of these cytokines contribute to HIV-1 suppression. HIV-1 entry and postintegration steps of viral replication are not affected, whereas reduced levels of reverse transcription products and of integrated proviruses, as determined by real-time PCR analysis, account for the suppression of HIV-1 gene expression in FcgammaR-activated MDMs. We found that FcgammaR-dependent activation of MDMs also inhibits the replication of HIV-2, SIVmac, and SIVagm, suggesting a common control mechanism for primate immunodeficiency lentiviruses in activated macrophages.
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Dates and versions

pasteur-00167539 , version 1 (21-08-2007)

Identifiers

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Annie David, Asier Sáez-Cirión, Pierre Versmisse, Odile Malbec, Bruno Iannascoli, et al.. The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages.. Journal of Immunology, 2006, 177 (9), pp.6291-300. ⟨10.4049/jimmunol.177.9.6291⟩. ⟨pasteur-00167539⟩
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