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Crystallographic studies of pharmacological sites in pentameric ligand-gated ion channels

Ludovic Sauguet , Azadeh Shahsavar , Marc Delarue
Biochimica et Biophysica Acta (BBA) - General Subjects, 2015, 1850 (3), pp.511-523. ⟨10.1016/j.bbagen.2014.05.007⟩
Journal articles pasteur-02167404v1
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How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA

Dariusz Czernecki , Pierre Legrand , Mustafa Tekpinar , Sandrine Rosario , Pierre-Alexandre Kaminski , et al.
Nature Communications, 2021, 12 (1), pp.2420. ⟨10.1038/s41467-021-22626-x⟩
Journal articles hal-03208082v1
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Genuine open form of the pentameric ligand-gated ion channel GLIC

Zaineb Fourati , Ludovic Sauguet , Marc Delarue
Acta crystallographica Section D : Structural biology [1993-..], 2015, 71 (3), pp.454-460. ⟨10.1107/S1399004714026698⟩
Journal articles pasteur-02174633v1
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Conferring a template-dependent polymerase activity to terminal deoxynucleotidyltransferase by mutations in the Loop1 region

Félix Romain , Isabelle Barbosa , Jérôme Gouge , François Rougeon , Marc Delarue
Nucleic Acids Research, 2009, 37 (14), pp.4642-4656. ⟨10.1093/nar/gkp460⟩
Journal articles pasteur-02174751v1
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Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases

Pierre Raia , Marta Carroni , Etienne Henry , Gérard Pehau-Arnaudet , Sébastien Brûlé , et al.
PLoS Biology, 2019, 17 (1), pp.e3000122. ⟨10.1371/journal.pbio.3000122⟩
Journal articles pasteur-02057758v1

Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel

Haidai Hu , Kenichi Ataka , Anaïs Menny , Zaineb Fourati , Ludovic Sauguet , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (52), pp.E12172-E12181. ⟨10.1073/pnas.1813378116⟩
Journal articles pasteur-02170327v1

Crystal Structure of the Extracellular Domain of a Bacterial Ligand-Gated Ion Channel

Hugues Nury , Nicolas Bocquet , Chantal Le Poupon , Bertrand Raynal , Ahmed Haouz , et al.
Journal of Molecular Biology, 2010, 395 (5), pp.1114-1127. ⟨10.1016/j.jmb.2009.11.024⟩
Journal articles pasteur-02174748v1

Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair

Jérôme Gouge , Sandrine Rosario , Félix Romain , Frédéric Poitevin , Pierre Béguin , et al.
EMBO Journal, 2015, 34 (8), pp.1126-1142. ⟨10.15252/embj.201489643⟩
Journal articles pasteur-02167413v1
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Conditioned Langevin Dynamics enables efficient sampling of transition paths

Marc Delarue , Patrice Koehl , Henri Orland
Preprints, Working Papers, ... cea-01708354v1

Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination

Jerome Loc'H , Sandrine Rosario , Marc Delarue
Structure, 2016, 24 (9), pp.1452-1463. ⟨10.1016/j.str.2016.06.014⟩
Journal articles pasteur-02174621v1
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Refinement of docked protein-ligand and protein-DNA structures using low frequency normal mode amplitude optimization

Erik Lindahl , Marc Delarue
Nucleic Acids Research, 2005, 33 (14), pp.4496-4506. ⟨10.1093/nar/gki730⟩
Journal articles pasteur-02175164v1
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Terminal deoxynucleotidyltransferase: the story of an untemplated DNA polymerase also capable of DNA bridging and templated synthesis across strands

Jérôme Loc’h , Marc Delarue
Current Opinion in Structural Biology, 2018, 53, pp.22-31. ⟨10.1016/⟩
Journal articles pasteur-03414957v1

Molecular recognition of canonical and deaminated bases by P. abyssi family B DNA polymerase.

Jérôme Gouge , Céline Ralec , Ghislaine Henneke , Marc Delarue
Journal of Molecular Biology, 2012, 423 (3), pp.315-36. ⟨10.1016/j.jmb.2012.07.025⟩
Journal articles istex hal-00775878v1
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Numerical Encodings of Amino Acids in Multivariate Gaussian Modeling of Protein Multiple Sequence Alignments

Patrice Koehl , Henri Orland , Marc Delarue
Molecules, 2019, 24 (1), pp.104. ⟨10.3390/molecules24010104⟩
Journal articles pasteur-02170325v1

Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation

Haidai Hu , Ákos Nemecz , Catherine van Renterghem , Zaineb Fourati , Ludovic Sauguet , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (17), pp.E3959-E3968. ⟨10.1073/pnas.1717700115⟩
Journal articles pasteur-02174579v1

Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism

Jérôme Gouge , Sandrine Rosario , Félix Romain , Pierre Béguin , Marc Delarue
Journal of Molecular Biology, 2013, 425 (22), pp.4334-4352. ⟨10.1016/j.jmb.2013.07.009⟩
Journal articles pasteur-02174639v1
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Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries

Irina Randrianjatovo-Gbalou , Sandrine Rosario , Odile Sismeiro , Hugo Varet , Rachel Legendre , et al.
Nucleic Acids Research, 2018, 46 (12), pp.6271-6284. ⟨10.1093/nar/gky413⟩
Journal articles pasteur-02170331v1

Dealing with structural variability in molecular replacement and crystallographic refinement through normal-mode analysis

Marc Delarue
Acta crystallographica Section D : Structural biology [1993-..], 2008, 64 (1), pp.40-48. ⟨10.1107/S0907444907053516⟩
Journal articles pasteur-02175141v1
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Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.

Gustavo Moraga-Cid , Ludovic Sauguet , Christèle Huon , Laurie Malherbe , Christine Girard-Blanc , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (9), pp.2865-70. ⟨10.1073/pnas.1417864112⟩
Journal articles hal-01230762v1
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Characterization of a triad of genes in cyanophage S-2L sufficient to replace adenine by 2-aminoadenine in bacterial DNA

Dariusz Czernecki , Frédéric Bonhomme , Pierre-Alexandre Kaminski , Marc Delarue
Nature Communications, 2021, 12 (1), pp.4710. ⟨10.1038/s41467-021-25064-x⟩
Journal articles pasteur-03327945v1
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Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution

Camille Samson , Pierre Legrand , Mustafa Tekpinar , Jef Rozenski , Mikhail Abramov , et al.
Biomolecules, 2020, 10 (12), pp.1647. ⟨10.3390/biom10121647⟩
Journal articles pasteur-03269775v1
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Fast and efficient purification of SARS-CoV-2 RNA dependent RNA polymerase complex expressed in Escherichia coli

Clément Madru , Ayten Dizkirici Tekpinar , Sandrine Rosario , Dariusz Czernecki , Sébastien Brûlé , et al.
PLoS ONE, 2021, 16 (4), pp.e0250610. ⟨10.1371/journal.pone.0250610⟩
Journal articles hal-03213590v1
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Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography

Ludovic Sauguet , Pierre Raia , Ghislaine Henneke , Marc Delarue
Nature Communications, 2016, ⟨10.1038/ncomms12227⟩
Journal articles pasteur-01389383v1
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Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel

Haidai Hu , Rebecca J. Howard , Ugo Bastolla , Erik Lindahl , Marc Delarue
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (24), pp.13437-13446. ⟨10.1073/pnas.1922701117⟩
Journal articles pasteur-02905610v1