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A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

Evangelos Andreakos , Laurent Abel , Donald Vinh , Elżbieta Kaja , Beth Drolet , et al.
Nature Immunology, 2022, 23 (2), pp.159-164. ⟨10.1038/s41590-021-01030-z⟩
Journal articles hal-03558195v1
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Negative selection on human genes underlying inborn errors depends on disease outcome and both the mode and mechanism of inheritance

Franck Rapaport , Bertrand Boisson , Anne Gregor , Vivien Béziat , Stéphanie Boisson-Dupuis , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (3), pp.e2001248118. ⟨10.1073/pnas.2001248118⟩
Journal articles hal-03372676v1
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Single-Cell and Bulk RNA-Sequencing Reveal Differences in Monocyte Susceptibility to Influenza A Virus Infection Between Africans and Europeans

Mary B O’neill , Hélène Quach , Julien Pothlichet , Yann Aquino , Aurélie Bisiaux , et al.
Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.768189⟩
Journal articles hal-03499159v1

Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant.

Stéphanie Boisson-Dupuis , Noe Ramirez-Alejo , Zhi Li , Etienne Patin , Geetha Rao , et al.
Science Immunology, 2018, 3 (30), pp.eaau8714. ⟨10.1126/sciimmunol.aau8714⟩
Journal articles pasteur-02070591v1
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Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard , Lindsey B. Rosen , Qian Zhang , Eleftherios Michailidis , Hans-Heinrich Hoffmann , et al.
Science, 2020, 370 (6515), pp.eabd4585. ⟨10.1126/science.abd4585⟩
Journal articles pasteur-02958871v1

Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency

Paul Bastard , Jeremy Manry , Jie Chen , Jérémie Rosain , Yoann Seeleuthner , et al.
Journal of Clinical Investigation, 2021, 131 (1), ⟨10.1172/JCI139980⟩
Journal articles hal-03552934v1
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A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

Jean-Laurent Casanova , Andrew Wood , Lluis Quintana-Murci , Ryan Minster , Andrés Moreno-Estrada , et al.
Journal of Experimental Medicine, 2022, 219 (6), pp.e20220028. ⟨10.1084/jem.20220028⟩
Journal articles pasteur-03681917v1
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Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

Aurélien Sokal , Paul Bastard , Pascal Chappert , Giovanna Barba-Spaeth , Slim Fourati , et al.
Journal of Experimental Medicine, 2023, 220 (1), pp.e20220258. ⟨10.1084/jem.20220258⟩
Journal articles pasteur-03847416v1

Human genetic and immunological determinants of critical COVID-19 pneumonia

Qian Zhang , Paul Bastard , Adem Karbuz , Adrian Gervais , Ahmad Abou Tayoun , et al.
Nature, 2022, 603 (7902), pp.587-598. ⟨10.1038/s41586-022-04447-0⟩
Journal articles hal-04074068v1
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Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children

Danyel Lee , Jérémie Le Pen , Ahmad Yatim , Beihua Dong , Yann Aquino , et al.
Science, 2023, 379 (6632), pp.eabo3627. ⟨10.1126/science.abo3627⟩
Journal articles hal-04089777v1
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Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian Zhang , Paul Bastard , Zhiyong Liu , Jérémie Le Pen , Marcela Moncada-Velez , et al.
Science, 2020, 370 (6515), pp.eabd4570. ⟨10.1126/science.abd4570⟩
Journal articles hal-02950982v1
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The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

Jérémy Manry , Paul Bastard , Adrian Gervais , Tom Le Voyer , Jérémie Rosain , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (21), pp.349-363. ⟨10.1073/pnas.2200413119⟩
Journal articles hal-03856619v2
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Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Paul Bastard , Adrian Gervais , Tom Le Voyer , Jeremie Rosain , Quentin Philippot , et al.
Science Immunology, 2021, 6 (62), pp.eabl4340. ⟨10.1126/sciimmunol.abl4340⟩
Journal articles hal-03358792v1
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X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

Mathieu P Rodero , Takaki Asano , Bertrand Boisson , Fanny Onodi , Daniela Matuozzo , et al.
Science Immunology, 2021, 6 (62), ⟨10.1126/sciimmunol.abl4348⟩
Journal articles hal-03367639v1
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SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

Vanessa Sancho-Shimizu , Petter Brodin , Aurélie Cobat , Catherine Biggs , Julie Toubiana , et al.
Journal of Experimental Medicine, 2021, 218 (6), ⟨10.1084/jem.20210446⟩
Journal articles hal-03549287v1