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De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

Thomas Laval , Laura Pedró-Cos , Wladimir Malaga , Laure Guenin-Macé , Alexandre Pawlik , et al.
eLife, 2021, 10, pp.e71946. ⟨10.7554/eLife.71946⟩
Journal articles pasteur-03534651v1
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Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis

Cyril Lefebvre , Wafa Frigui , Nawel Slama , Françoise Lauzeral-Vizcaino , Patricia Constant , et al.
Scientific Reports, 2020, 10 (1), pp.2112. ⟨10.1038/s41598-020-58967-8⟩
Journal articles pasteur-02474005v1

The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis

Nawel Slama , Stevie Jamet , Wafa Frigui , Alexandre Pawlik , Daria Bottai , et al.
Molecular Microbiology, 2016, 99 (4), pp.794-807. ⟨10.1111/mmi.13266⟩
Journal articles pasteur-02618562v1
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Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

Fadel Sayes , Catherine Blanc , Louis S Ates , Nathalie Deboosere , Mickael Orgeur , et al.
Cell Reports, 2018, 23 (4), pp.1072-1084. ⟨10.1016/j.celrep.2018.03.125⟩
Journal articles pasteur-02046037v1
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Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis

Fabien Le Chevalier , Alessandro Cascioferro , Wafa Frigui , Alexandre Pawlik , Eva C. Boritsch , et al.
Scientific Reports, 2015, 5 (1), pp.16918. ⟨10.1038/srep16918⟩
Journal articles pasteur-02618632v1
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Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential

Irene Pérez , Santiago Uranga , Fadel Sayes , Wafa Frigui , Sofia Samper , et al.
EBioMedicine, 2020, 55, pp.102761. ⟨10.1016/j.ebiom.2020.102761⟩
Journal articles pasteur-02615240v1
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TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages

Daria Bottai , Wafa Frigui , Fadel Sayes , Mariagrazia Di Luca , Dalila Spadoni , et al.
Nature Communications, 2020, 11 (1), pp.684. ⟨10.1038/s41467-020-14508-5⟩
Journal articles pasteur-02473990v1
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Pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

Eva C. Boritsch , Wafa Frigui , Alessandro Cascioferro , Wladimir Malaga , Gilles Etienne , et al.
Nature Microbiology, 2016, 1 (février 2016), ⟨10.1038/nmicrobiol.2015.19⟩
Journal articles pasteur-01265519v1
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Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli

Aideen C Allen , Wladimir Malaga , Cyril Gaudin , Arnaud Volle , Flavie Moreau , et al.
Nature Microbiology, 2021, 6 (8), pp.1082-1093. ⟨10.1038/s41564-021-00938-4⟩
Journal articles hal-03318178v1
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CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

Fadel Sayes , Alexandre Pawlik , Wafa Frigui , Matthias I Gröschel , Samuel Crommelynck , et al.
PLoS Pathogens, 2016, 12 (7), pp.e1005770. ⟨10.1371/journal.ppat.1005770⟩
Journal articles pasteur-02615226v1
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Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts

Mickael Orgeur , Wafa Frigui , Alexandre Pawlik , Simon Clark , Ann Williams , et al.
Microbial Genomics, 2021, 7 (2), ⟨10.1099/mgen.0.000505⟩
Journal articles pasteur-03255655v1
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Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection.

Matthias I Gröschel , Fadel Sayes , Sung Jae Shin , Wafa Frigui , Alexandre Pawlik , et al.
Cell Reports, 2017, 18 (11), pp.2752-2765. ⟨10.1016/j.celrep.2017.02.057⟩
Journal articles pasteur-01503927v1
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Mycobacterial virulence: impact on immunogenicity and vaccine research

Vera Kroesen , Jan Madacki , Wafa Frigui , Fadel Sayes , Roland Brosch
F1000Research, 2019, 8, pp.2025. ⟨10.12688/f1000research.20572.1⟩
Journal articles pasteur-02615238v1
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ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains

Jan Madacki , Mickael Orgeur , Guillem Mas Fiol , Wafa Frigui , Laurence Ma , et al.
mBio, 2021, 12 (3), ⟨10.1128/mBio.00965-21⟩
Journal articles pasteur-03413286v1

ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection

Roxane Simeone , Daria Bottai , Wafa Frigui , Laleh Majlessi , Roland Brosch
Tuberculosis, 2015, 95, pp.S150-S154. ⟨10.1016/⟩
Journal articles pasteur-02863008v1
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RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

Louis S Ates , Fadel Sayes , Wafa Frigui , Roy Ummels , Merel P M Damen , et al.
PLoS Pathogens, 2018, 14 (6), pp.e1007139. ⟨10.1371/journal.ppat.1007139⟩
Journal articles pasteur-02046090v1
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Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP.

Wafa Frigui , Daria Bottai , Laleh Majlessi , Marc Monot , Emmanuelle Josselin , et al.
PLoS Pathogens, 2008, 4 (2), pp.e33. ⟨10.1371/journal.ppat.0040033⟩
Journal articles pasteur-01370872v1
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Phenotypic and genomic hallmarks of a novel, potentially pathogenic rapidly growing Mycobacterium species related to the Mycobacterium fortuitum complex

Reem Gharbi , Varun Khanna , Wafa Frigui , Besma Mhenni , Roland Brosch , et al.
Scientific Reports, 2021, 11 (1), pp.13011. ⟨10.1038/s41598-021-91737-8⟩
Journal articles pasteur-03547033v1

A Specific Polymorphism in Mycobacterium tuberculosis H37Rv Causes Differential ESAT-6 Expression and Identifies WhiB6 as a Novel ESX-1 Component

Luis Solans , Nacho Aguiló , Sofia Samper , Alexandre Pawlik , Wafa Frigui , et al.
Infection and Immunity, 2014, 82 (8), pp.3446-3456. ⟨10.1128/iai.01824-14⟩
Journal articles pasteur-02618736v1
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Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

Philip Supply , Michael Marceau , Sophie Mangenot , David Roche , Carine Rouanet , et al.
Nature Genetics, 2013, 45 (2), pp.172-179. ⟨10.1038/ng.2517⟩
Journal articles pasteur-02615220v1
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PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis

Barbara Rieck , Giulia Degiacomi , Michael Zimmermann , Alessandro Cascioferro , Francesca Boldrin , et al.
PLoS Pathogens, 2017, 13 (5), pp.e1006399. ⟨10.1371/journal.ppat.1006399⟩
Journal articles pasteur-01570229v1

ESAT-6 Secretion-Independent Impact of ESX-1 Genes espF and espG1 on Virulence of Mycobacterium tuberculosis

Daria Bottai , Laleh Majlessi , Roxane Simeone , Wafa Frigui , Christine Laurent , et al.
Journal of Infectious Diseases, 2011, 203 (8), pp.1155-1164. ⟨10.1093/infdis/jiq089⟩
Journal articles pasteur-02862998v1

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation

Daria Bottai , Mariagrazia Di Luca , Laleh Majlessi , Wafa Frigui , Roxane Simeone , et al.
Molecular Microbiology, 2012, 83 (6), pp.1195-1209. ⟨10.1111/j.1365-2958.2012.08001.x⟩
Journal articles pasteur-02615214v1