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authFullName_s : Olivier Helynck
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SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

Marc Lavigne , Olivier Helynck , Pascal Rigolet , Rofia Boudria-Souilah , Mireille Nowakowski , et al.
Nucleic Acids Research, 2021, 49 (13), pp.7695-7712. ⟨10.1093/nar/gkab571⟩
Journal articles hal-03281130v1
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Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT

Stéphanie Dabo , Patrick Maillard , Milagros Collados Rodriguez , Marianne Doré Hansen , Sabrina Mazouz , et al.
Scientific Reports, 2017, 7 (1), pp.16129. ⟨10.1038/s41598-017-16089-8⟩
Journal articles pasteur-01682150v1
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A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism

Paris Laskaris , Rocío Vicentefranqueira , Olivier Helynck , Grégory Jouvion , José Antonio Calera , et al.
Antimicrobial Agents and Chemotherapy, 2018, 62 (6), pp.e02510-17. ⟨10.1128/AAC.02510-17⟩
Journal articles pasteur-01968421v1

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Marianne Lucas-Hourani , Hélène Munier-Lehmann , Olivier Helynck , Anastassia Komarova , Philippe Desprès , et al.
Journal of visualized experiments : JoVE, 2014, 87, pp.e51222. ⟨10.3791/51222⟩
Journal articles pasteur-01113538v1
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Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

Flora Magnotti , Daria Chirita , Sarah Dalmon , Amandine Martin , Pauline Bronnec , et al.
Cell Reports, 2022, 41 (2), pp.111472. ⟨10.1016/j.celrep.2022.111472⟩
Journal articles hal-03811426v1
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Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening

Pierre-Olivier Vidalain , Marianne Lucas-Hourani , Olivier Helynck , Frédéric Tangy , Hélène Munier-Lehmann
Médecine/Sciences, 2015, 31 (1), pp.98-104. ⟨10.1051/medsci/20153101019⟩
Journal articles pasteur-01174082v1

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).

Marianne Lucas-Hourani , Hélène Munier-Lehmann , Farah El Mazouni , Nicholas A Malmquist , Jane Harpon , et al.
Journal of Medicinal Chemistry, 2015, pp.10.1021/acs.jmedchem.5b00606. ⟨10.1021/acs.jmedchem.5b00606⟩
Journal articles pasteur-01170546v1

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)pyrimidine Derivatives as Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

Hélène Munier-Lehmann , Marianne Lucas-Hourani , Sandrine Guillou , Olivier Helynck , Gigliola Zanghi , et al.
Journal of Medicinal Chemistry, 2015, 58, pp.860-877. ⟨10.1021/jm501446r⟩
Journal articles pasteur-01101526v1
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High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.

Nathalie Aulner , Anne Danckaert , Eline Rouault-Hardoin , Julie Desrivot , Olivier Helynck , et al.
PLoS Neglected Tropical Diseases, 2013, 7 (4), pp.e2154. ⟨10.1371/journal.pntd.0002154⟩
Journal articles pasteur-01433415v1

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase.

Sara van Poecke , Hélène Munier-Lehmann , Olivier Helynck , Matheus Froeyen , Serge van Calenbergh
Bioorganic and Medicinal Chemistry, 2011, 19, epub ahead of print. ⟨10.1016/j.bmc.2011.10.021⟩
Journal articles pasteur-00645423v1
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Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands

Zhicheng Zhou , Isabelle Staropoli , Anne Brelot , Peggy Suzanne , Aurélien Lesnard , et al.
Molecules, 2023, 28 (3), pp.1156. ⟨10.3390/molecules28031156⟩
Journal articles pasteur-04096396v1

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis

Maria Buchieri , Mena Cimino , Sonia Rebollo-Ramirez , Claire Beauvineau , Alessandro Cascioferro , et al.
Journal of Medicinal Chemistry, 2017, 60 (17), pp.7425 - 7433. ⟨10.1021/acs.jmedchem.7b00726⟩
Journal articles pasteur-01693404v1
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Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity

Marianne Lucas-Hourani , Daniel Dauzonne , Pierre Jorda , Gaëlle Cousin , Alexandru Lupan , et al.
PLoS Pathogens, 2013, 9 (10), pp.e1003678. ⟨10.1371/journal.ppat.1003678⟩
Journal articles pasteur-01113535v1
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Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response

Marianne Lucas-Hourani , Daniel Dauzonne , Hélène Munier-Lehmann , Samira Khiar , Sébastien Nisole , et al.
Antimicrobial Agents and Chemotherapy, 2017, 61 (10), pp.e00383-17. ⟨10.1128/AAC.00383-17⟩
Journal articles pasteur-01693518v1
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Synergy of the antibiotic colistin with echinocandin antifungals in Candida species.

Ute Zeidler , Marie-Elisabeth Bougnoux , Alexandru Lupan , Olivier Helynck , Antonia Doyen , et al.
Journal of Antimicrobial Chemotherapy, 2013, 68 (6), pp.1285-96. ⟨10.1093/jac/dks538⟩
Journal articles pasteur-00849830v1
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High seroprevalence but short-lived immune response to SARS-CoV-2 infection in Paris

François Anna , Sophie Goyard , Ana Ines Lalanne , Fabien Nevo , Marion Gransagne , et al.
European Journal of Immunology, 2021, 51 (1), pp.180-190. ⟨10.1101/2020.10.25.20219030⟩
Journal articles pasteur-02988663v2
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Identification of a small molecule that primes the type I interferon response to cytosolic DNA

Samira Khiar , Marianne Lucas-Hourani , Sebastien Nisole , Nikaia Smith , Olivier Helynck , et al.
Scientific Reports, 2017, 7 (1), pp.2561. ⟨10.1038/s41598-017-02776-z⟩
Journal articles pasteur-01570224v1
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First-in-class allosteric inhibitors of bacterial IMPDHs

Thomas Alexandre , Alexandru Lupan , Olivier Helynck , Sophie Vichier-Guerre , Laurence Dugué , et al.
European Journal of Medicinal Chemistry, 2019, 167, pp.124-132. ⟨10.1016/j.ejmech.2019.01.064⟩
Journal articles pasteur-02125232v1
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Prevalence of SARS-CoV-2 antibodies in France: results from nationwide serological surveillance

Stéphane Le Vu , Gabrielle Jones , François Anna , Thierry Rose , Jean-Baptiste Richard , et al.
Nature Communications, 2021, ⟨10.1101/2020.10.20.20213116⟩
Journal articles pasteur-03147098v2