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authFullName_s : Laurence A Mulard

Convergent synthesis of the methyl glycosides of a tetra- and a pentasaccharide fragment of the Shigella flexneri serotype 2a O-specific polysaccharide

Fabienne Ségat-Dioury , Laurence A Mulard
Tetrahedron: Asymmetry, 2002, 13 (20), pp.2211-2222. ⟨10.1016/S0957-4166(02)00580-3⟩
Journal articles istex hal-02509428v1
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Exploratory N‐Protecting Group Manipulation for the Total Synthesis of Zwitterionic Shigella sonnei Oligosaccharides

Debashis Dhara , Laurence A Mulard
Chemistry - A European Journal, 2021, 27 (18), pp.5694 - 5711. ⟨10.1002/chem.202003480⟩
Journal articles pasteur-03722328v1

Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

Charles Gauthier , Pierre Chassagne , Francois-Xavier Theillet , Catherine Guerreiro , Francoise Thouron , et al.
Organic & Biomolecular Chemistry, 2014, 12 (24), pp.4218-4232. ⟨10.1039/c3ob42586j⟩
Journal articles hal-01172002v1

Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxidation

Pierre Chassagne , Laurent Raibaut , Catherine Guerreiro , Laurence A Mulard
Tetrahedron, 2013, 69 (48), pp.10337-10350. ⟨10.1016/j.tet.2013.10.011⟩
Journal articles pasteur-02043363v1
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Combination of High-Resolution Multistage Ion Mobility and Tandem MS with High Energy of Activation to Resolve the Structure of Complex Chemoenzymatically Synthesized Glycans

David Ropartz , Mathieu Fanuel , Simon Ollivier , Adrien Lissarrague , Mounir Benkoulouche , et al.
Analytical Chemistry, 2022, 94 (4), pp.2279-2287. ⟨10.1021/acs.analchem.1c04982⟩
Journal articles hal-03573196v1

Effects of backbone substitutions on the conformational behavior of Shigella flexneri O-antigens: implications for vaccine strategy.

François-Xavier Theillet , Catherine Simenel , Catherine Guerreiro , Armelle Phalipon , Laurence A Mulard , et al.
Glycobiology, 2011, 21 (1), pp.109-21. ⟨10.1093/glycob/cwq136⟩
Journal articles hal-00550773v1

Investigation towards bivalent chemically defined glycoconjugate immunogens prepared from acid-detoxified lipopolysaccharide of Vibrio cholerae O1, serotype Inaba.

Cyrille Grandjean , Alain Boutonnier , Bruno Dassy , Jean-Michel Fournier , Laurence A Mulard
Glycoconjugate Journal, 2008, epub ahead of print. ⟨10.1007/s10719-008-9160-6⟩
Journal articles pasteur-00335927v1

Vaccination against shigellosis: is it the path that is difficult or is it the difficult that is the path?

Armelle Phalipon , Laurence A Mulard , Philippe Sansonetti
Microbes and Infection, 2008, 10 (9), pp.1057-62. ⟨10.1016/j.micinf.2008.07.016⟩
Journal articles istex pasteur-00335872v1
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Bacterial polysaccharides as major surface antigens: interest in O-acetyl substitutions

Laurence A Mulard
Carbohydrate Chemistry : chemical and biological approaches, 43, Royal Society of Chemistry (London), 2017, 978-1-78801-003-0 (print) ; 978-1-78801-064-1 (PDF) ; 978-1-78801-409-0 (ePUB). ⟨10.1039/9781788010641-00071⟩
Book sections pasteur-01851517v1
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Toward a Multivalent Synthetic Oligosaccharide-Based Conjugate Vaccine against Shigella: State-of-the-Art for a Monovalent Prototype and Challenges

Armelle Phalipon , Laurence A Mulard
Vaccines, 2022, Special Issue Frontiers in Shigella Vaccine Development, 10 (3), pp.403. ⟨10.3390/vaccines10030403⟩
Journal articles pasteur-03699792v1

Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease.

Karen Wright , Catherine Guerreiro , Isabelle Laurent , Françoise Baleux , Laurence A Mulard
Organic & Biomolecular Chemistry, 2004, 2 (10), pp.1518-27. ⟨10.1039/b400986J⟩
Journal articles pasteur-00166853v1

Synthesis of two linear PADRE conjugates bearing a deca- or pentadecasaccharide B epitope as potential synthetic vaccines against Shigella flexneri serotype 2a infection.

Frédéric Bélot , Catherine Guerreiro , Françoise Baleux , Laurence A Mulard
Chemistry - A European Journal, 2005, 11 (5), pp.1625-35. ⟨10.1002/chem.200400903⟩
Journal articles istex pasteur-00166810v1

Efficient Iterative Synthesis of O-Acetylated Tri- to Pentadecasaccharides Related to the Lipopolysaccharide of Shigella flexneri Type 3 a through Di- and Trisaccharide Glycosyl Donors

Zhaoyu Hu , Aileen F Bongat White , Laurence A Mulard
Chemistry - An Asian Journal, 2017, 12 (4), pp.419 - 439. ⟨10.1002/asia.201600819⟩
Journal articles pasteur-01627935v1
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Computer-aided engineering of a branching sucrase for the glucodiversification of a tetrasaccharide precursor of S. flexneri antigenic oligosaccharides

Mounir Benkoulouche , Akli Ben Imeddourene , Louis-Antoine Barel , Dorian Lefebvre , Mathieu Fanuel , et al.
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-99384-9⟩
Journal articles hal-03382404v1
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Multigram synthesis of an orthogonally-protected pentasaccharide for use as a glycan precursor in a Shigella flexneri 3a conjugate vaccine: application to a ready-for-conjugation decasaccharide

Johan Cornil , Zhaoyu Hu , Marion Bouchet , Laurence A Mulard
Organic Chemistry Frontiers, 2021, 8 (22), pp.6279-6299. ⟨10.1039/d1qo00761k⟩
Journal articles pasteur-03722329v1

Synthesis of branched tri-to pentasaccharides representative of fragments of Shigella flexneri serotypes 3a and/or X O-antigens

Julien Boutet , Catherine Guerreiro , Laurence A Mulard
Tetrahedron, 2008, pp.10558-10572. ⟨10.1016/j.tet.2008.08.080⟩
Journal articles istex pasteur-00336071v1

Rational design and immunogenicity of liposome-based diepitope constructs: application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen.

Fatouma Said Hassane , Armelle Phalipon , Myriam Tanguy , Catherine Guerreiro , Frédéric Bélot , et al.
Vaccine, 2009, 27 (39), pp.5419-26. ⟨10.1016/j.vaccine.2009.06.031⟩
Journal articles istex hal-00414241v1

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

D. Topalis , K. Alvarez , K. Barral , Hélène Munier-Lehmann , B. Schneider , et al.
Nucleosides, Nucleotides and Nucleic Acids, 2008, 27 (4), pp.319-31. ⟨10.1080/15257770801941952⟩
Journal articles pasteur-00316017v1

Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody.

B. Vulliez-Le Normand , F. A. Saul , Armelle Phalipon , F. Bélot , C. Guerreiro , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2008, 105 (29), pp.9976-81. ⟨10.1073/pnas.0801711105⟩
Journal articles pasteur-00336029v1

Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate

Stephane Salamone , Catherine Guerreiro , Emmanuelle Cambon , Isabelle André , Magali Remaud Simeon , et al.
Chemical Communications, 2015, 51 (13), pp.2581 - 2584. ⟨10.1039/c4cc08805k⟩
Journal articles hal-01269073v1

A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity.

Robert M F van Der Put , Tae Hee Kim , Catherine Guerreiro , Françoise Thouron , Peter Hoogerhout , et al.
Bioconjugate Chemistry, 2016, 27 (4), pp.883-92. ⟨10.1021/acs.bioconjchem.5b00617⟩
Journal articles pasteur-01350027v1

Convergent synthesis, NMR and conformational analysis of tetra-and petasaccharide haptens of the Shigella flexneri serotype 5a O-specific polysaccharide

Laurence A Mulard , Marie-Jeanne Clément , Anne Imberty , Muriel Delepierre
European Journal of Organic Chemistry, 2002, 15, pp.2486-2498. ⟨10.1002/1099-0690(200208)2002:15<2486::AID-EJOC2486>3.0.CO;2-E⟩
Journal articles istex pasteur-00371353v1
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Applying Pairwise Combinations of Amino Acid Mutations for Sorting Out Highly Efficient Glucosylation Tools for Chemo-Enzymatic Synthesis of Bacterial Oligosaccharides

Elise Champion , Frédéric Guerin , Claire Moulis , Sophie Barbe , Thu Hoai Tran , et al.
Journal of the American Chemical Society, 2012, 134 (45), pp.18677 - 18688. ⟨10.1021/ja306845b⟩
Journal articles hal-03003058v1
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Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine.

Armelle Phalipon , Corina Costachel , Cyrille Grandjean , Audrey Thuizat , Catherine Guerreiro , et al.
Journal of Immunology, 2006, 176 (3), pp.1686-94. ⟨10.4049/jimmunol.176.3.1686⟩
Journal articles pasteur-00166117v1

Structural mimicry of O-antigen by a peptide revealed in a complex with an antibody raised against Shigella flexneri serotype 2a.

François-Xavier Theillet , Frederick A Saul , Brigitte Vulliez-Le Normand , Sylviane Hoos , Franco Felici , et al.
Journal of Molecular Biology, 2009, 388 (4), pp.839-50. ⟨10.1016/j.jmb.2009.03.057⟩
Journal articles istex hal-00414251v1

Conformational studies of the O-specific polysaccharide of Shigella flexneri 5a and of four related synthetic pentasaccharide fragments using NMR and molecular modeling.

Marie-Jeanne Clément , Anne Imberty , Armelle Phalipon , Serge Pérez , Catherine Simenel , et al.
Journal of Biological Chemistry, 2003, 278 (48), pp.47928-36. ⟨10.1074/jbc.M308259200⟩
Journal articles pasteur-00369608v1

Design of alpha-transglucosidases of controlled specificity for programmed chemoenzymatic synthesis of antigenic oligosaccharides.

Elise Champion , Isabelle André , Claire Moulis , Julien Boutet , Karine Descroix , et al.
Journal of the American Chemical Society, 2009, 131 (21), pp.7379-89. ⟨10.1021/ja900183h⟩
Journal articles hal-00414248v1

Efficient synthesis of six tri- to hexasaccharide fragments of Shigella flexneri serotypes 3a and/or X O-antigen, including a study on acceptors containing N-trichloroacetylglucosamine versus N-acetylglucosamine.

Julien Boutet , Catherine Guerreiro , Laurence A Mulard
Journal of Organic Chemistry, 2009, 74 (7), pp.2651-70. ⟨10.1021/jo802127z⟩
Journal articles hal-00414254v1

A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection.

Armelle Phalipon , Myriam Tanguy , Cyrille Grandjean , Catherine Guerreiro , Frédéric Bélot , et al.
Journal of Immunology, 2009, 182 (4), pp.2241-7. ⟨10.4049/jimmunol.0803141⟩
Journal articles hal-00414256v1

Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study

Dani Cohen , Jacob Atsmon , Cécile Artaud , Shiri Meron-Sudai , Marie-Lise Gougeon , et al.
The Lancet Infectious Diseases, 2021, 21 (4), pp.546-558. ⟨10.1016/S1473-3099(20)30488-6⟩
Journal articles pasteur-03699905v1