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authFullName_s : Jean-Pierre Changeux

Loss of high‐affinity nicotinic receptors increases the vulnerability to excitotoxic lesion and decreases the positive effects of an enriched environment

Alessio Zanardi , Rosaria Ferrari , Giuseppina Leo , Uwe Maskos , Jean-Pierre Changeux , et al.
FASEB Journal, 2007, 21 (14), pp.4028-4037. ⟨10.1096/fj.07-8260com⟩
Journal articles pasteur-02935305v1

Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism.

Antoine Taly , Marc Delarue , Thomas Grutter , Michael Nilges , Nicolas Le Novere , et al.
Biophysical Journal, 2005, 88 (6), pp.3954-65. ⟨10.1529/biophysj.104.050229⟩
Journal articles pasteur-00162514v1

Persistent decrease in synaptic efficacy induced by nicotine at Schaffer collateral-CA1 synapses in the immature rat hippocampus.

Laura Maggi , Elisabetta Sola , Federico Minneci , Corentin Le Magueresse , Jean-Pierre Changeux , et al.
The Journal of Physiology, 2004, 559 (Pt 3), pp.863-74. ⟨10.1113/jphysiol.2004.067041⟩
Journal articles pasteur-00163488v1

Rational understanding of nicotinic receptors drug binding

Thomas Grutter , Nicolas Le Novere , Jean-Pierre Changeux
Current Topics in Medicinal Chemistry, 2004, 4 (6), pp.645-50. ⟨10.2174/1568026043451177⟩
Journal articles pasteur-00163310v1

Nicotine upregulates its own receptors through enhanced intracellular maturation.

Jérôme Sallette , Stéphanie Pons , Anne Devillers-Thiery , Martine Soudant , Lia Prado de Carvalho , et al.
Neuron, 2005, 46 (4), pp.595-607. ⟨10.1016/j.neuron.2005.03.029⟩
Journal articles pasteur-00162539v1

Acquisition and performance of delayed-response tasks: a neural network model

Thomas Gisiger , Michel Kerszberg , Jean-Pierre Changeux
Cerebral Cortex, 2005, 15 (5), pp.489-506. ⟨10.1093/cercor/bhh149⟩
Journal articles pasteur-00162562v1

Attention-deficit/hyperactivity disorder: a plausible mouse model?

Sylvie Granon , Jean-Pierre Changeux
Acta Paediatrica, 2006, 95 (6), pp.645-9. ⟨10.1080/08035250600719747⟩
Journal articles pasteur-00161418v1

A discerning amateur

Sylvie Aubenas , Jean-Pierre Changeux , Nathalie Boulouch
Martin Karplus : la couleur des années 1950, Bibliothèque nationale de France; les Éd. de l'Oeil, pp.14-15, 2013, 978-2-35137-143-5
Book sections hal-04169203v1
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Proactive epigenesis and ethical innovation: A neuronal hypothesis for the genesis of ethical rules.

Kathinka Evers , Jean-Pierre Changeux
EMBO Reports, 2016, 17 (10), pp.1361 - 1364. ⟨10.15252/embr.201642783⟩
Journal articles pasteur-01406900v1

Intermediate closed state for glycine receptor function revealed by cysteine cross-linking

Marie S. Prevost , Gustavo Moraga-Cid , Catherine van Renterghem , Stuart J. Edelstein , Jean-Pierre Changeux , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (42), pp.17113 - 17118. ⟨10.1073/pnas.1317009110⟩
Journal articles pasteur-01721683v1
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Nicotine reverses hypofrontality in animal models of addiction and schizophrenia.

Fani Koukouli , Marie Rooy , Dimitrios Tziotis , Kurt A Sailor , Heidi C O'Neill , et al.
Nature Medicine, 2017, 23 (3), pp.347-353. ⟨10.1038/nm.4274⟩
Journal articles pasteur-01452384v1

Nicotinic Receptors at the Amino Acid Level

Pierre-Jean Corringer , Nicolas Le Novère , Jean-Pierre Changeux
Annual Review of Pharmacology and Toxicology, 2000, 40 (1), pp.431 - 458. ⟨10.1146/annurev.pharmtox.40.1.431⟩
Journal articles pasteur-01719004v1

Improved Secondary Structure Predictions for a Nicotinic Receptor Subunit: Incorporation of Solvent Accessibility and Experimental Data into a Two-Dimensional Representation

Nicolas Le Novère , Pierre-Jean Corringer , Jean-Pierre Changeux
Biophysical Journal, 1999, 76 (5), pp.2329 - 2345. ⟨10.1016/S0006-3495(99)77390-X⟩
Journal articles pasteur-01719007v1
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A strategy for designing allosteric modulators of transcription factor dimerization

Sho Oasa , Vladana Vukojević , Rudolf Rigler , Igor Tsigelny , Jean-Pierre Changeux , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (5), pp.2683-2686. ⟨10.1073/pnas.1915531117⟩
Journal articles hal-02535881v1
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Une hypothèse nicotinique pour Covid-19 avec des implications préventives et thérapeutiques

Jean-Pierre Changeux , Zahir Amoura , Félix A. Rey , Makoto Miyara
2020, pp.33-39
Translation hal-02914557v1

Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing.

Fani Koukouli , Marie Rooy , Jean-Pierre Changeux , Uwe Maskos
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (51), pp.14823-14828. ⟨10.1073/pnas.1614417113⟩
Journal articles hal-01548328v1

Long-term effects of chronic nicotine exposure on brain nicotinic receptors.

Morgane Besson , Sylvie Granon , Monica Mameli-Engvall , Isabelle Cloëz-Tayarani , Nicolas Maubourguet , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (19), pp.8155-60. ⟨10.1073/pnas.0702698104⟩
Journal articles pasteur-00161245v1

Targeting transcription to the neuromuscular synapse.

Laurent Schaeffer , Alban de Kerchove d'Exaerde , Jean-Pierre Changeux
Neuron, 2001, 31 (1), pp.15-22. ⟨10.1016/S0896-6273(01)00353-1⟩
Journal articles hal-00077622v1

Executive and social behaviors under nicotinic receptor regulation

Sylvie Granon , Philippe Faure , Jean-Pierre Changeux
Proceedings of the National Academy of Sciences of the United States of America, 2003, 100 (16), pp.9596-9601. ⟨10.1073/pnas.1533498100⟩
Journal articles hal-02541881v1

Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints.

Karen L. Martinez , Yann Gohon , Pierre-Jean Corringer , Christophe Tribet , Fabienne Mérola , et al.
FEBS Letters, 2002, 528 (1-3), pp.251-6. ⟨10.1016/S0014-5793(02)03306-9⟩
Journal articles pasteur-01720087v1
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Differential mechanisms underlie trace and delay conditioning in Drosophila

Dhruv Grover , Jen-Yung Chen , Jiayun Xie , Jinfang Li , Jean-Pierre Changeux , et al.
Journal articles pasteur-03576224v1

A low dose of nicotine is sufficient to produce nicotine withdrawal in mice.

Morgane Besson , Sandra Suarez , Jean-Pierre Changeux , Sylvie Granon
Health, 2009, 2 (1), pp.1-7. ⟨10.4236/health.2010.21001⟩
Journal articles hal-00635638v1

Aggressive behavior during social interaction in mice is controlled by the modulation of tyrosine hydroxylase expression in the prefrontal cortex.

Karine Cambon , Renata dos Santos Coura , Laurent Groc , A. Carbon , Dinah Weissmann , et al.
Neuroscience, 2010, 171 (3), pp.840-51. ⟨10.1016/j.neuroscience.2010.09.015⟩
Journal articles hal-01463412v1

Paradoxical allosteric effects of competitive inhibitors on neuronal alpha7 nicotinic receptor mutants

Sonia Bertrand , Anne Devillers-Thiéry , Eleonora Palma , Bruno Buisson , Stuart J. Edelstein , et al.
NeuroReport, 1997, 8 (16), pp.3591-6
Journal articles pasteur-01718282v1

Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors.

Denis Servent , Hung Lam Thanh , Stéphanie Antil , Daniel Bertrand , Pierre-Jean Corringer , et al.
Journal of Physiology - Paris, 1998, 92 (2), pp.107-11. ⟨10.1016/S0928-4257(98)80146-0⟩
Journal articles istex pasteur-01718432v1

Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor.

Pierre-Jean Corringer , Sonia Bertrand , Jean-Luc Galzi , Anne Devillers-Thiéry , Jean-Pierre Changeux , et al.
Neuron, 1999, 22 (4), pp.831-43. ⟨10.1016/S0896-6273(00)80741-2⟩
Journal articles pasteur-01718442v1

A method for soluble overexpression of the alpha7 nicotinic acetylcholine receptor extracellular domain

Markus Fischer , Pierre-Jean Corringer , Karin Schott , Adelbert Bacher , Jean-Pierre Changeux
Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 (6), pp.3567 - 3570. ⟨10.1073/pnas.041594798⟩
Journal articles pasteur-01659650v1

The nicotinic 6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors

Jeffrey. S. Wieskopf , Jayanti Mathur , Walrati Limapichat , Michael.R Post , Mona Al-Qazzaz , et al.
Science Translational Medicine, 2015, 7 (287), pp.287ra72 - 287ra72. ⟨10.1126/scitranslmed.3009986⟩
Journal articles pasteur-01573816v1

Nicotinic and muscarinic receptors in the rat prefrontal cortex: differential roles in working memory, response selection and effortful processing

Sylvie Granon , Bruno Poucet , Catherine Thinus-Blanc , Jean-Pierre Changeux , Catherine Vidal
Psychopharmacology, 1995, 119 (2), pp.139-144. ⟨10.1007/BF02246154⟩
Journal articles istex hal-01385318v1

Allosteric regulation of pentameric ligand-gated ion channels: An emerging mechanistic perspective

Antoine Taly , Jérôme Hénin , Jean-Pierre Changeux , Marco Cecchini
Channels, 2014, 8 (4), pp.350-360. ⟨10.4161/chan.29444⟩
Journal articles hal-01498037v1