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authFullName_s : Alexandre Chenal
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Allosteric activation of Bordetella pertussis adenylyl cyclase by calmodulin: molecular dynamics and mutagenesis studies.

Edithe Selwa , Marilyne Davi , Alexandre Chenal , Ana-Cristina Sotomayor-Pérez , Daniel Ladant , et al.
Journal of Biological Chemistry, 2014, 289 (30), pp.21131-41. ⟨10.1074/jbc.M113.530410⟩
Journal articles pasteur-01107494v1

Deciphering Membrane Insertion of the Diphtheria Toxin T Domain by Specular Neutron Reflectometry and Solid-State NMR Spectroscopy

Alexandre Chenal , Lydia Prongidi-Fix , Aurélie Perier , Chistopher Aisenbrey , Grégory Vernier , et al.
Journal of Molecular Biology, 2009, 391 (5), pp.872-883. ⟨10.1016/j.jmb.2009.06.061⟩
Journal articles istex hal-01151673v1
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Type III secretion effectors of the IpaH family are E3 ubiquitin ligases.

John R Rohde , Ashton Breitkreutz , Alexandre Chenal , Philippe Sansonetti , Claude Parsot
Cell Host and Microbe, 2007, 1 (1), pp.77-83. ⟨10.1016/j.chom.2007.02.002⟩
Journal articles pasteur-01540876v1
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Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin.

Johanna C Karst , Ana Cristina Sotomayor Pérez , J Iñaki Guijarro , Bertrand Raynal , Alexandre Chenal , et al.
Biochemistry, 2010, 49 (2), pp.318-28. ⟨10.1021/bi9016389⟩
Journal articles hal-00512114v1

Membrane Interaction of Botulinum Neurotoxin A Translocation (T) Domain THE BELT REGION IS A REGULATORY LOOP FOR MEMBRANE INTERACTION

Marie Galloux , Heidi Vitrac , Caroline Montagner , Stephanie Raffestin , Michel R. Popoff , et al.
Journal of Biological Chemistry, 2008, 283 (41), pp.27668-27676. ⟨10.1074/jbc.M802557200⟩
Journal articles hal-01187636v1
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The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro

Alexis Voegele , Mirko Sadi , Dorothée Raoux-Barbot , Thibaut Douche , Mariette Matondo , et al.
Toxins, 2019, Special Issue RTX Toxins, 11 (2), pp.111. ⟨10.3390/toxins11020111⟩
Journal articles pasteur-02329482v1
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Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy

Alexandre Chenal , Daniel Ladant
Toxins, 2018, 10 (7), pp.302. ⟨10.3390/toxins10070302⟩
Journal articles pasteur-02565647v1
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Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis

Raymond W Bourdeau , Enrico Malito , Alexandre Chenal , Brian L Bishop , Mark W Musch , et al.
Journal of Biological Chemistry, 2009, 284 (21), pp.14645-14656. ⟨10.1074/jbc.M807631200⟩
Journal articles pasteur-01540766v1
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From bulk to plasmonic nanoparticle surfaces: the behavior of two potent therapeutic peptides, octreotide and pasireotide

Belén Hernández , Eduardo López-Tobar , Santiago Sanchez-Cortes , Yves-Marie Coïc , Bruno Baron , et al.
Physical Chemistry Chemical Physics, 2016, 18 (35), pp.24437 - 24450. ⟨10.1039/c6cp04421b⟩
Journal articles pasteur-01378668v1
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A Robust and Sensitive Spectrophotometric Assay for the Enzymatic Activity of Bacterial Adenylate Cyclase Toxins

Marilyne Davi , Mirko Sadi , Irene Pitard , Alexandre Chenal , Daniel Ladant
Toxins, 2022, 14 (10), pp.691. ⟨10.3390/toxins14100691⟩
Journal articles hal-03858756v1
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Hydrogen/Deuterium Exchange Mass Spectrometry for the Structural Analysis of Detergent-Solubilized Membrane Proteins

Darragh O’brien , Véronique Hourdel , Alexandre Chenal , Sébastien Brier
Springer. Expression, Purification, and Structural Biology of Membrane Proteins, 2127, Humana, New York, NY, pp.339-358, 2020, Methods in Molecular Biology, 978-1-0716-0372-7. ⟨10.1007/978-1-0716-0373-4_22⟩
Book sections pasteur-02559306v1

Post-translational acylation controls the folding and functions of the CyaA RTX toxin

Darragh O'Brien , Sara E Cannella , Alexis Voegele , Dorothée Raoux-Barbot , Marilyne Davi , et al.
FASEB Journal, 2019, 33 (9), pp.10065-10076. ⟨10.1096/fj.201802442RR⟩
Journal articles pasteur-02330713v1
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A High‐Affinity Calmodulin‐Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells

Alexis Voegele , Mirko Sadi , Darragh Patrick O'Brien , Pauline Gehan , Dorothée Raoux‐barbot , et al.
Advanced Science, 2021, pp.2003630. ⟨10.1002/advs.202003630⟩
Journal articles pasteur-03211832v1
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Post-translational acylation controls the folding and functions of the CyaA RTX toxin

Darragh P O'Brien , Sara E Cannella , Alexis Voegele , Dorothée Raoux-Barbot , Maryline Davi , et al.
Preprints, Working Papers, ... pasteur-03221015v1

Dissecting the Structural and Chemical Determinants of the “Open-to-Closed” Motion in the Mannosyltransferase PimA from Mycobacteria

Ane Rodrigo-Unzueta , Mattia Ghirardello , Saioa Urresti , Ignacio Delso , David Giganti , et al.
Biochemistry, 2020, 59 (32), pp.2934-2945. ⟨10.1021/acs.biochem.0c00376⟩
Journal articles pasteur-03210105v1
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Functional and structural consequences of epithelial cell invasion by Bordetella pertussis adenylate cyclase toxin

Christelle Angely , Daniel Ladant , Emmanuelle Planus , Bruno Louis , Marcel Filoche , et al.
PLoS ONE, 2020, 15 (5), pp.e0228606. ⟨10.1371/journal.pone.0228606⟩
Journal articles inserm-02893474v1

Translocation and calmodulin-activation of the adenylate cyclase toxin (CyaA) of Bordetella pertussis

Alexis Voegele , Darragh P. O'Brien , Orso Subrini , Nicolas Sapay , Sara E. Cannella , et al.
Pathogens and Disease, 2018, 76 (8), pp.fty085. ⟨10.1093/femspd/fty085⟩
Journal articles hal-02184809v1
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Clostridium septicum alpha-toxin forms pores and induces rapid cell necrosis.

Oliver Knapp , Elke Maier , Sanae Ben Mkaddem , Roland Benz , Marcelle Bens , et al.
Toxicon, 2010, 55 (1), pp.61-72. ⟨10.1016/j.toxicon.2009.06.037⟩
Journal articles pasteur-01509604v1
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Disorder-to-Order Transition in the CyaA Toxin RTX Domain: Implications for Toxin Secretion

Ana-Cristina Sotomayor-Pé , Daniel Ladant , Alexandre Chenal
Toxins, 2014, 7 (1), pp.1-20. ⟨10.3390/toxins7010001⟩
Journal articles pasteur-01132650v1
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Membrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region

Alexis Voegele , Orso Subrini , Nicolas Sapay , Daniel Ladant , Alexandre Chenal
Toxins, 2017, 9 (11), pp.369. ⟨10.3390/toxins9110369⟩
Journal articles pasteur-02882330v1
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Development of Conformational Antibodies to Detect Bcl-xL's Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells

Alexis Gonneaud , Fatima-Zohra Fakhir , Emeline Landas , Enora Le Tallec , Elisabeth Chartier-Garcia , et al.
International Journal of Molecular Sciences, 2020, 21 (20), pp.7625. ⟨10.3390/ijms21207625⟩
Journal articles hal-03031819v1

SEC-SAXS and HDX-MS: A powerful combination. The case of the calcium-binding domain of a bacterial toxin

Darragh O'Brien , Sebastien Brier , Daniel Ladant , Dominique Durand , Alexandre Chenal , et al.
Biotechnology and Applied Biochemistry, 2018, 65 (1), pp.62-68. ⟨10.1002/bab.1577⟩
Journal articles hal-02329435v1
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Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the bordetella pertussis adenylate cyclase toxin.

Ana-Cristina Sotomayor Pérez , Johanna C Karst , Marilyne Davi , J Iñaki Guijarro , Daniel Ladant , et al.
Journal of Molecular Biology, 2010, 397 (2), pp.534-49. ⟨10.1016/j.jmb.2010.01.031⟩
Journal articles hal-00512116v1
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Amyloid Fibrils Formed by the Programmed Cell Death Regulator Bcl-xL.

Alexandre Chenal , Charlotte Vendrely , Heidi Vitrac , Johanna C Karst , Alexis Gonneaud , et al.
Journal of Molecular Biology, 2011, epub ahead of print. ⟨10.1016/j.jmb.2011.11.024⟩
Journal articles pasteur-00654783v1
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Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis

Darragh P. O'Brien , Dominique Durand , Alexis Voegele , Véronique Hourdel , Marilyne Davi , et al.
PLoS Biology, 2017, 15 (12), pp.e2004486. ⟨10.1371/journal.pbio.2004486⟩
Journal articles hal-02294928v1

Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough

Darragh P. O'Brien , Ana Cristina Sotomayor Perez , Johanna Karst , Sara E. Cannella , Véronique Yvette Ntsogo Enguéné , et al.
Journal articles hal-02183106v1
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Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion

Darragh P. O’brien , Belen Hernandez , Dominique Durand , Véronique Hourdel , Ana-Cristina Sotomayor-Pérez , et al.
Scientific Reports, 2016, 5, ⟨10.1038/srep14223⟩
Journal articles pasteur-01406897v1
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The Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pH

Anne Araye , Amélie Goudet , Julien Barbier , Sylvain Pichard , Bruno Baron , et al.
PLoS ONE, 2016, 11 (4), pp.e0153401. ⟨10.1371/journal.pone.0153401⟩
Journal articles pasteur-01378747v1
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MEMHDX: An interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets

Véronique Hourdel , Stevenn Volant , Darragh P. O'Brien , Alexandre Chenal , Julia Chamot-Rooke , et al.
Journal articles pasteur-01377055v1
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Anchoring Sites of Fibrillogenic Peptide Hormone Somatostatin-14 on Plasmonic Nanoparticles

Eduardo López-Tobar , Belén Hernández , Johanna Gómez , Alexandre Chenal , José Vicente Garcia-Ramos , et al.
Journal of Physical Chemistry C, 2015, 119 (15), pp.8273-8279. ⟨10.1021/acs.jpcc.5b00485⟩
Journal articles pasteur-01406738v1