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            <funder>M.R. is supported by grant from the Fondation pour la Recherche Médicale (FDM202206015344) and received ‘La Bourse Junior’ from the Société de Pathologie Infectieuse de Langue Française (SPILF). She is member of the Ecole de l’Inserm Liliane Bettencourt Programme.</funder>
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            <idno type="halRefHtml">&lt;i&gt;Trends in Immunology&lt;/i&gt;, 2024, 45, pp.406-418. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.it.2024.04.013"&gt;&amp;#x27E8;10.1016/j.it.2024.04.013&amp;#x27E9;&lt;/a&gt;</idno>
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                <term xml:lang="en">sarcoidosis</term>
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              <p>Sarcoidosis is a chronic immune disease of unknown origin for which we still lack an immunological framework unifying causal agents, host factors, and natural history of disease. Here, we discuss the initial triggers of disease, and how myeloid cells drive granuloma formation and contribute to immunopathogenesis. We highlight recent advances in our understanding of innate immune memory and propose the hypothesis that maladaptive innate immune training connects previous environmental exposure to granuloma maintenance and expansion. Lastly, we consider how this hypothesis may open novel therapeutic avenues, while corticosteroids remain the front-line treatment.</p>
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