%0 Journal Article %T Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection %+ Department of Medical Microbiology and Infection Prevention [Amsterdam] %+ Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB) %+ Life and Soft %+ University of Southampton %+ University of Oxford %+ The Scripps Research Institute [La Jolla, San Diego] %+ Imperial College London %+ Amsterdam UMC - Amsterdam University Medical Center %+ Erasmus University Medical Center [Rotterdam] (Erasmus MC) %+ University of Washington [Seattle] %+ AIMM Therapeutics [Amsterdam, the Netherlands] %+ Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)) %+ Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur) %A Brouwer, Philip J.M. %A Brinkkemper, Mitch %A Maisonnasse, Pauline %A Dereuddre-Bosquet, Nathalie %A Grobben, Marloes %A Claireaux, Mathieu %A de Gast, Marlon %A Marlin, Romain %A Chesnais, Virginie %A Diry, Ségolène %A Allen, Joel %A Watanabe, Yasunori %A Giezen, Julia %A Kerster, Gius %A Turner, Hannah %A van der Straten, Karlijn %A van der Linden, Cynthia %A Aldon, Yoann %A Naninck, Thibaut %A Bontjer, Ilja %A Burger, Judith %A Poniman, Meliawati %A Mykytyn, Anna %A Okba, Nisreen M.A. %A Schermer, Edith %A van Breemen, Marielle %A Ravichandran, Rashmi %A Caniels, Tom %A van Schooten, Jelle %A Kahlaoui, Nidhal %A Contreras, Vanessa %A Lemaître, Julien %A Chapon, Catherine %A Fang, Raphaël Ho Tsong %A Villaudy, Julien %A Sliepen, Kwinten %A van der Velden, Yme %A Haagmans, Bart %A de Bree, Godelieve %A Ginoux, Eric %A Ward, Andrew %A Crispin, Max %A King, Neil %A van der Werf, Sylvie %A van Gils, Marit %A Le Grand, Roger %A Sanders, Rogier %Z This work was supported by a Netherlands Organisation for Scientific Research (NWO) Vici grant (to R.W.S.); the Bill & Melinda Gates Foundation through the Collaboration for AIDS Vaccine Discovery (CAVD) grants OPP1111923, OPP1132237, and INV-002022 (to R.W.S. and/or N.P.K.), INV-008352/OPP1153692 and OPP1196345/INV-008813 (to M.C.), and OPP1170236 (to A.B.W.); the Fondation Dormeur, Vaduz (R.W.S. and to M.J.v.G.) and Health-Holland PPS-allowance LSHM20040 (to M.J.v.G.); the University of Southampton Coronavirus Response Fund (M.C.); and the Netherlands Organisation for Health Research and Development ZONMW (B.L.H). M.J.v.G. is a recipient of an AMC Fellowship from Amsterdam UMC and a COVID-19 grant from the Amsterdam Institute for Infection and Immunity. R.W.S. and M.J.v.G. are recipients of support from the University of Amsterdam Proof of Concept fund (contract 200421) as managed by Innovation Exchange Amsterdam (IXA). The Infectious Disease Models and Innovative Therapies (IDMIT) research infrastructure is supported by the Programme Investissements d’Avenir, managed by the National Research Agency (ANR) under reference ANR-11-INBS-0008. The Fondation Bettencourt Schueller and the Region Ile-de-France contributed to the implementation of IDMIT’s facilities and imaging technologies. The non-human primate study received financial support from REACTing, the ANR (AM-CoV-Path), and the European Infrastructure TRANSVAC2 (730964). %< avec comité de lecture %@ 0092-8674 %J Cell %I Elsevier %V 184 %N 5 %P 1188-1200.e19 %8 2021-03 %D 2021 %R 10.1016/j.cell.2021.01.035 %M 33577765 %Z Life Sciences [q-bio]Journal articles %G English %2 https://pasteur.hal.science/pasteur-04098199/document %2 https://pasteur.hal.science/pasteur-04098199/file/1-s2.0-S0092867421000787-main.pdf %L pasteur-04098199 %U https://pasteur.hal.science/pasteur-04098199 %~ PASTEUR %~ CEA %~ CNRS %~ OPENAIRE %~ CEA-UPSAY %~ UNIV-PARIS-SACLAY %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ UP-SCIENCES %~ UNIVERSITE-PARIS-SACLAY %~ ANR %~ GS-LIFE-SCIENCES-HEALTH %~ GS-HEALTH-DRUG-SCIENCES %~ PASTEUR_UMR3569 %~ GMV-ARN