%0 Journal Article %T The Interplay Between Viruses and RNAi Pathways in Insects %+ University of Florida [Gainesville] (UF) %+ Virus et Interférence ARN - Viruses and RNA Interference %A Bonning, Bryony, C %A Saleh, Maria-Carla %Z B.C.B. acknowledges support from grants from the National Science Foundation Industry-University Cooperative Research Center, the Center for Arthropod Management Technologies under grants IIP-1338775 and 1821914; from industry partners; and from the USDA/NIFA 2019-06119, Hatch, and State of Florida funds. M.-C.S. is funded by the EuropeanResearch Council (FP7/2013–2019 ERC CoG 615220) and the French Government’s Investissement d’Avenir program Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (grant ANR-10-LABX-62-IBEID) %< avec comité de lecture %@ 0066-4170 %J Annual Review of Entomology %I Annual Reviews %V 66 %N 1 %P 61-79 %8 2021-01-07 %D 2021 %R 10.1146/annurev-ento-033020-090410 %M 33417818 %K RNAi pathways antiviral immunity endogenous viral elements viral suppressors of RNAi %K RNAi pathways %K antiviral immunity %K endogenous viral elements %K viral suppressors of RNAi %Z Life Sciences [q-bio]Journal articles %X As an overarching immune mechanism, RNA interference (RNAi) displays pathogen specificity and memory via different pathways. The small interfering RNA (siRNA) pathway is the primary antiviral defense mechanism against RNA viruses of insects and plays a lesser role in defense against DNA viruses. Reflecting the pivotal role of the siRNA pathway in virus selection, different virus families have independently evolved unique strategies to counter this host response, including protein-mediated, decoy RNA–based, and microRNA-based strategies. In this review, we outline the interplay between insect viruses and the different pathways of the RNAi antiviral response; describe practical application of these interactions for improved expression systems and for pest and disease management; and highlight research avenues for advancement of the field. %G English %L pasteur-04087648 %U https://pasteur.hal.science/pasteur-04087648 %~ PASTEUR %~ CNRS %~ OPENAIRE %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ ANR %~ VIR-RNA-INTERF %~ PASTEUR_UMR3569