%0 Journal Article %T Serological evidence of rift valley fever Phlebovirus and Crimean-Congo hemorrhagic fever orthonairovirus infections among pygmies in the east region of Cameroon %+ Centre Pasteur du Cameroun %+ Epidémiologie et Physiopathologie des Virus Oncogènes (EPVO (UMR_3569 / U-Pasteur_3)) %A Sadeuh-Mba, Serge Alain %A Yonga Wansi, Gide Martial %A Demanou, Maurice %A Gessain, Antoine %A Njouom, Richard %Z This work was financially supported by the Centre Pasteur of Cameroon (CPC) and the DFG project (GR980/4–1). %< avec comité de lecture %@ 1743-422X %J Virology Journal %I BioMed Central %V 15 %N 1 %P 63 %8 2018-12 %D 2018 %R 10.1186/s12985-018-0977-8 %M 29625611 %K Cameroon %K Crimean-Congo hemorrhagic fever orthonairovirus %K Pygmies %K Rift valley fever phlebovirus %K Seroprevalence %Z Life Sciences [q-bio]Journal articles %X Background: Rift Valley Fever Phlebovirus (RVFV) and Crimean-Congo Hemorrhagic Fever Orthonairovirus (CCHFV) specific antibodies had been documented among humans in urban settings of the southwestern and northern Cameroon in the late 1980s. Recently, evidence for enzootic circulation of RVFV was reported among livestock in both rural and urban settings in Cameroon. However, current estimates of human exposure to RVFV and CCHFV are still to be documented in Cameroon, especially in rural areas. The aim of this study was to assess the seroprevalence of RVFV and CCHFV in rural settings in the Southeastern rain forest of Cameroon.Results: Using Enzyme-linked Immunosorbent Assays, the presence of RVFV and CCHFV Immunoglobulin G antibodies was investigated in plasma samples originating from 137 Pygmies from four villages of the East region of Cameroon. The studied population was found to be 12.4% (17/137) and 4.4% (6/137) seropositive for RVFV and CCHFV, respectively. The rates of RVFV IgG were comparable between the age groups and sex. Conversely, the rate of CCHFV IgG was significantly higher among the 41-60 years old participants (p = 0.02).Conclusions: This study provides a substantial evidence of the circulation of RVFV and CCHFV among rural inhabitants of the East region of Cameroon. %G English %Z We are thankful to the participants or their parents/legal guardians for participating to this study and to Mrs. Gwladys Monamele for reviewing the English language. %2 https://pasteur.hal.science/pasteur-04079454/document %2 https://pasteur.hal.science/pasteur-04079454/file/s12985-018-0977-8.pdf %L pasteur-04079454 %U https://pasteur.hal.science/pasteur-04079454 %~ PASTEUR %~ UNIV-PARIS7 %~ RIIP %~ CNRS %~ RIIP_CAMEROUN %~ USPC %~ UNIV-PARIS %~ UP-SCIENCES %~ EPI-PHYS-VIR-ONC %~ PASTEUR_UMR3569