%0 Journal Article %T High Human T-Cell Leukemia Virus Type 1c Proviral Loads Are Associated With Diabetes and Chronic Kidney Disease: Results of a Cross-Sectional Community Survey in Central Australia %+ Alice Springs Hospital %+ Flinders University [Adelaide, Australia] %+ National Serology Reference Laboratory %+ Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology (EPVO (UMR_3569 / U-Pasteur_3)) %+ University of New South Wales [Sydney] (UNSW) %A Talukder, Mohammad Radwanur %A Woodman, Richard %A Pham, Hai %A Wilson, Kim %A Gessain, Antoine %A Kaldor, John %A Einsiedel, Lloyd %Z This study was funded by the National Health and Medical Research Council (project grant 1088517). %< avec comité de lecture %@ 1058-4838 %J Clinical Infectious Diseases %I Oxford University Press (OUP) %V 76 %N 3 %P e820-e826 %8 2023-02-01 %D 2023 %R 10.1093/cid/ciac614 %M 35903021 %K Australia %K HTLV-1 %K HTLV-1 proviral load %K chronic kidney disease %K diabetes %Z Life Sciences [q-bio]Journal articles %X BackgroundA link between chronic inflammation and several noncommunicable diseases (NCDs) has been established. Although chronic infection with the human T-cell leukemia virus type 1 (HTLV-1) is the recognized cause of several inflammatory diseases and these are associated with a high number of HTLV-1–infected cells in peripheral blood (proviral load [PVL]), possible interactions between PVL and NCDs have not been studied at a community level.MethodsAdult Aboriginal residents of 7 remote communities were invited to complete a health survey between 25 August 2014 and 30 June 2018. Blood was drawn for HTLV-1 serology and PVL, and relevant medical conditions were obtained from health records. Associations between HTLV-1 PVL and diabetes, chronic kidney disease (CKD), and coronary artery disease (CAD) were determined using logistic regression, adjusting for available confounders.ResultsAmong 510 participants (56% of the estimated adult resident population, 922), 197 (38.6%) were HTLV-1–infected. A high HTLV-1 PVL was associated with a 2-fold increase in the odds of diabetes and CKD (diabetes, adjusted odds ratio [aOR], 1.95; 95% confidence interval [CI], 1.06–3.61; P = .033 and CKD: aOR, 2.00; 95% CI, 1.03–3.8; P = .041). A nonsignificant association between high PVL and CAD (aOR, 7.08; 95% CI, 1.00–50.18; P = .05) was found for participants aged <50 years at the time of angiography.ConclusionsIn a community-based study in central Australia, people with HTLV-1 who had high HTLV-1 PVL were more likely to have diabetes and CKD. These findings have potential clinical implications. %G English %L pasteur-04079366 %U https://pasteur.hal.science/pasteur-04079366 %~ PASTEUR %~ CNRS %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ UP-SCIENCES %~ TEST3-HALCNRS %~ EPI-PHYS-VIR-ONC %~ PASTEUR_UMR3569