%0 Journal Article %T Determinants of Chikungunya and O’nyong-Nyong Virus Specificity for Infection of Aedes and Anopheles Mosquito Vectors %+ Génétique et Génomique des Insectes Vecteurs - Genetics and Genomics of Insect Vectors %+ Ecole Doctorale Complexité du Vivant (ED515) %+ Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors %A Cottis, Solène %A Blisnick, Adrien, A %A Failloux, Anna-Bella %A Vernick, Kenneth, D %Z This work received financial support to KDV from the Agence Nationale de la Recherche, #ANR-19-CE35-0004 ArboVec; National Institutes of Health, NIAID #AI145999; and French Laboratoire d’Excellence “Integrative Biology of Emerging Infectious Diseases” #ANR-10-LABX-62-IBEID, and to ABF from the Agence Nationale de la Recherche, #ANR-19-CE35-0004 ArboVec; and French Laboratoire d’Excellence “Integrative Biology of Emerging Infectious Diseases” #ANR-10-LABX-62-IBEID. %< avec comité de lecture %@ 1999-4915 %J Viruses %I MDPI %V 15 %N 3 %P 589 %8 2023-02-21 %D 2023 %R 10.3390/v15030589 %M 36992298 %K chikungunya virus %K o'nyong-nyong virus %K host-pathogen interactions %K vector specificity %K Aedes %K Anopheles %Z Life Sciences [q-bio]Journal articles %X Mosquito-borne diseases caused by viruses and parasites are responsible for more than 700 million infections each year. Anopheles and Aedes are the two major vectors for, respectively, malaria and arboviruses. Anopheles mosquitoes are the primary vector of just one known arbovirus, the alphavirus o’nyong-nyong virus (ONNV), which is closely related to the chikungunya virus (CHIKV), vectored by Aedes mosquitoes. However, Anopheles harbor a complex natural virome of RNA viruses, and a number of pathogenic arboviruses have been isolated from Anopheles mosquitoes in nature. CHIKV and ONNV are in the same antigenic group, the Semliki Forest virus complex, are difficult to distinguish via immunodiagnostic assay, and symptomatically cause essentially the same human disease. The major difference between the arboviruses appears to be their differential use of mosquito vectors. The mechanisms governing this vector specificity are poorly understood. Here, we summarize intrinsic and extrinsic factors that could be associated with vector specificity by these viruses. We highlight the complexity and multifactorial aspect of vectorial specificity of the two alphaviruses, and evaluate the level of risk of vector shift by ONNV or CHIKV. %G English %2 https://pasteur.hal.science/pasteur-04064474/document %2 https://pasteur.hal.science/pasteur-04064474/file/Determinants%20of%20Chikungunya%20and%20O%27Nyong-Nyong%20virus%20.pdf %L pasteur-04064474 %U https://pasteur.hal.science/pasteur-04064474 %~ PASTEUR %~ CNRS %~ SORBONNE-UNIVERSITE %~ SORBONNE-UNIV %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ SU-TI %~ ANR %~ ALLIANCE-SU %~ TEST3-HALCNRS %~ TEST4-HALCNRS %~ GEN-GENO-INSECT-VECT %~ PASTEUR_UMR2000 %~ TEST5-HALCNRS