%0 Journal Article %T Actin subversion for productive Plasmodium hepatocyte invasion [Spotlight] %+ University of Heidelberg, Medical Faculty %+ Dynamique des Interactions Hôte-Pathogène - Dynamics of Host-Pathogen Interactions %A Frischknecht, Freddy %A Enninga, Jost %Z Our work is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Projektnummer 240245660 – SFB 1129, SPP2225 and SPP2332 (F.F.), the ANR (program ‘PureMagRupture’ and ‘RabReprogram’; to J.E.) as well as the ERC (CoG ‘Endosubvert’ to J.E.). J.E. is member of the LabExes IBEID and Milieu Interieur. %< avec comité de lecture %@ 1471-4922 %J Trends in Parasitology %I Elsevier %8 2023 %D 2023 %R 10.1016/j.pt.2023.03.003 %K Plasmodium %K actin rearrangements %K bacterial pathogens %K host cell invasion. %Z Life Sciences [q-bio]Journal articles %X Productive invasion of hepatocytes by Plasmodium sporozoites is a key step of infection. The parasites traverse hepatocytes before targeting one of them to form a parasitophorous vacuole for parasite expansion. Schepis et al. show the induction of membrane ruffling via host Rho GTPases by Plasmodium sporozoites facilitating productive invasion. %G English %L pasteur-04059699 %U https://pasteur.hal.science/pasteur-04059699 %~ PASTEUR %~ CNRS %~ OPENAIRE %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ ANR %~ DYNAMICS-HOST-PATHOGEN-INTERACTIONS %~ UMR3691