Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis - Institut Pasteur Access content directly
Journal Articles Science Translational Medicine Year : 2022

Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis

Tine Dalby
Thomas Åkerlund
Jessica Darenberg
Norman Fry
Karolina Gullsby
Qiushui He
  • Function : Author
David Litt
Helena Martini
Denis Piérard
Marc Stegger
Samuel Hong
Philippe Lemey
Julian Parkhill

Abstract

As with other pathogens, competitive interactions between Bordetella pertussis strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28.1 transmission chains circulating within a subnational region, with the number of chains strongly associated with host population size. It took 5 to 10 years for B. pertussis to be homogeneously distributed throughout Europe, with the same time frame required for the United States. Increased fitness of pertactin-deficient strains after implementation of acellular vaccines, but reduced fitness otherwise, can explain long-term genotype dynamics. These findings highlight the role of vaccine policy in shifting local diversity of a pathogen that is responsible for 160,000 deaths annually.

Dates and versions

pasteur-03821663 , version 1 (19-10-2022)

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Noémie Lefrancq, Valérie Bouchez, Nadia Fernandes, Alex-Mikael Barkoff, Thijs Bosch, et al.. Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis. Science Translational Medicine, 2022, 14 (642), pp.eabn3253. ⟨10.1126/scitranslmed.abn3253⟩. ⟨pasteur-03821663⟩
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