%0 Journal Article %T Mother-to-Child Transmission of Arboviruses during Breastfeeding: From Epidemiology to Cellular Mechanisms %+ Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology (EPVO (UMR_3569 / U-Pasteur_3)) %A Desgraupes, Sophie %A Hubert, Mathieu %A Gessain, Antoine %A Ceccaldi, Pierre-Emmanuel %A Vidy, Aurore %Z No external funding %< avec comité de lecture %@ 1999-4915 %J Viruses %I MDPI %V 13 %N 7 %P 1312 %8 2021-07-07 %D 2021 %R 10.3390/v13071312 %M 34372518 %K arboviruses %K mother-to-child transmission %K breastfeeding %K breast milk %K intestinal epithelium %K mammary epithelium %K Zika virus %K yellow fever virus %K dengue virus %K Chikungunya virus %K West Nile virus %K barrier crossing mechanisms %K viral transmission %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Santé publique et épidémiologie %Z Life Sciences [q-bio]/Human health and pathology/Infectious diseasesJournal articles %X Most viruses use several entry sites and modes of transmission to infect their host (parenteral, sexual, respiratory, oro-fecal, transplacental, transcutaneous, etc.). Some of them are known to be essentially transmitted via arthropod bites (mosquitoes, ticks, phlebotomes, sandflies, etc.), and are thus named arthropod-borne viruses, or arboviruses. During the last decades, several arboviruses have emerged or re-emerged in different countries in the form of notable outbreaks, resulting in a growing interest from scientific and medical communities as well as an increase in epidemiological studies. These studies have highlighted the existence of other modes of transmission. Among them, mother-to-child transmission (MTCT) during breastfeeding was highlighted for the vaccine strain of yellow fever virus (YFV) and Zika virus (ZIKV), and suggested for other arboviruses such as Chikungunya virus (CHIKV), dengue virus (DENV), and West Nile virus (WNV). In this review, we summarize all epidemiological and clinical clues that suggest the existence of breastfeeding as a neglected route for MTCT of arboviruses and we decipher some of the mechanisms that chronologically occur during MTCT via breastfeeding by focusing on ZIKV transmission process. %G English %2 https://pasteur.hal.science/pasteur-03805346/document %2 https://pasteur.hal.science/pasteur-03805346/file/viruses-13-01312-1.pdf %L pasteur-03805346 %U https://pasteur.hal.science/pasteur-03805346 %~ PASTEUR %~ CNRS %~ SANTE_PUB_INSERM %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ UP-SCIENCES %~ EPI-PHYS-VIR-ONC %~ PASTEUR_UMR3569