%0 Journal Article %T Seroepidemiological Reconstruction of Long-term Chikungunya Virus Circulation in Burkina Faso and Gabon %+ International Vaccine Institute (IVI) %+ School of Public Health [Montréal, Canada] %+ Centre de Recherches Médicales de Lambaréné %+ University of Tübingen %+ Medizinische Universität Wien = Medical University of Vienna %+ Centre Muraz [Bobo-Dioulasso, Burkina Faso] %+ Institut Pasteur [Paris] (IP) %+ University of Texas Medical Branch at Galveston %+ University of Cambridge [UK] (CAM) %+ Coalition for Epidemic Preparedness Innovations [Washington, DC, États-Unis] (CEPI) %A Lim, Jacqueline Kyungah %A Ridde, Valery %A Agnandji, Selidji Todagbe %A Lell, Bertrand %A Yaro, Seydou %A Yang, Jae Seung %A Hoinard, Damien %A Weaver, Scott %A Vanhomwegen, Jessica %A Salje, Henrik %A Yoon, In Kyu %Z H. S. was supported by the European Research Council (grant number 804744). I.-K. Y. and J. K. L. were supported by the Bill & Melinda Gates Foundation (grant number 1053432). S. C. W. was supported by the National Institutes of Health (grant number R24 AI120942).Potential conflicts of interest. H. S. reports being a paid consultant to Gavi, the Vaccine Alliance, for work understanding the potential of chikungunya vaccines. All other authors report no potential conflicts. Funding to pay the Open Access publication charges for this article was provided by the University of Cambridge. %< avec comité de lecture %@ 0022-1899 %J Journal of Infectious Diseases %I Oxford University Press (OUP) %P jiac246 %8 2022 %D 2022 %R 10.1093/infdis/jiac246 %M 35710849 %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Microbiology and Parasitology/Virology %Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles %X Abstract Chikungunya virus (CHIKV) is a major public health concern worldwide. However, infection levels are rarely known, especially in Africa. We recruited individuals from Ouagadougou, Burkina Faso and Lambaréné, Gabon (age range, 1–55 years), tested their blood for CHIKV antibodies, and used serocatalytic models to reconstruct epidemiological histories. In Ouagadougou, 291 of 999 (29.1%) individuals were seropositive, ranging from 2% among those aged <10 years to 66% in those aged 40–55 years. We estimated there were 7 outbreaks since the 1970s but none since 2001, resulting in 600 000 infections in the city, none of which were reported. However, we could not definitively conclude whether infections were due to CHIKV or o’nyong-nyong, another alphavirus. In Lambaréné, 117 of 427 (27%) participants were seropositive. Our model identified a single outbreak sometime since 2007, consistent with the only reported CHIKV outbreak in the country. These findings suggest sporadic outbreaks in these settings and that the burden remains undetected or incorrectly attributed. %G English %2 https://pasteur.hal.science/pasteur-03721387/document %2 https://pasteur.hal.science/pasteur-03721387/file/jiac246.pdf %L pasteur-03721387 %U https://pasteur.hal.science/pasteur-03721387 %~ PASTEUR %~ SANTE_PUB_INSERM %~ OPENAIRE