%0 Journal Article %T New insights into Human Pegivirus-1 (HPgV-1) genotypes diversity in sub-Saharan Africa %+ Institut National de la Transfusion Sanguine [Paris] (INTS) %+ Environnement et Risques infectieux - Environment and Infectious Risks (ERI) %+ Université de Yaoundé I %+ National Blood Center [Antananarivo, Madagascar] (NBC) %+ National Blood Center [Bujumbura, Burundi] (NBC) %+ National Blood Center [Bamako, Mali] (NBC) %+ National Blood Center [Nouakchott, Mauritania] (NBC) %+ National Blood Center [Niamey, Niger] (NBC) %+ National Blood Center [Kinshasa, Democratic Republic of the Congo] (NBC) %A Sauvage, Virginie %A Gomez, Johanna %A Boizeau, Laure %A Vandenbogaert, Mathias %A Barbier, Léa %A Tagny, Claude Tayou %A Rakoto Alson, Aimée Olivat %A Bizimana, Pascal %A Coulibaly, Sekou Oumar %A Boullahi, Mohamed Abdallahi %A Soumana, Hadiza %A Mbensa, Guy %A Caro, Valérie %A Laperche, Syria %Z This research was supported by grant number 39-2015 from the “Agence Nationale de Sécurité du Medicament et des Produits de Santé” (Paris, France) under the project “Viral metagenomics: a new tool for the surveillance of emerging infectious agents applied to blood safety”. %< avec comité de lecture %@ 1567-1348 %J Infection, Genetics and Evolution %I Elsevier %V 94 %N 11 %P 104995 %8 2021-10 %D 2021 %R 10.1016/j.meegid.2021.104995 %M 34246798 %Z Life Sciences [q-bio]/Human health and pathology/Infectious diseasesJournal articles %X Since its first detection in 1979, dengue fever has been considered a major public health issue in the Lao People’s Democratic Republic (PDR). Dengue virus (DENV) serotype 1 was the cause of an epidemic in 2010–2011. Between 2012 and 2020, major outbreaks due successively to DENV-3, DENV-4 and recently DENV-2 have been recorded. However, DENV-1 still co-circulated in the country over this period. Here, we summarize epidemiological and molecular data of DENV-1 between 2016 and 2020 in the Lao PDR. Our data highlight the continuous circulation of DENV-1 in the country at levels ranging from 16% to 22% among serotyping tests. In addition, the phylogenetic analysis has revealed the circulation of DENV-1 genotype I at least since 2008 with a co-circulation of different clusters. Sequence data support independent DENV-1 introductions in the Lao PDR correlated with an active circulation of this serotype at the regional level in Southeast Asia. The maintenance of DENV-1 circulation over the last ten years supports a low level of immunity against this serotype within the Lao population. Thereby, the risk of a DENV-1 epidemic cannot be ruled out in the future, and this emphasizes the importance of maintaining an integrated surveillance approach to prevent major outbreaks. %G English %L pasteur-03713401 %U https://pasteur.hal.science/pasteur-03713401 %~ PASTEUR %~ AFRIQ %~ UNIV-PARIS %~ UNIVERSITE-PARIS