%0 Journal Article %T Ebola Virus Disease in the Democratic Republic of Congo %+ Centre International de Recherches Médicales de Franceville (CIRMF) %+ Institut National de Recherche Biomédicale [Kinshasa] (INRB) %+ Epidémiologie et Physiopathologie des Virus Oncogènes (EPVO (UMR_3569 / U-Pasteur_3)) %+ Ministry of Health, Kinshasa, Democratic Republic of the Congo %+ World Health Organization [Kinshasa, Democratic Republic of Congo] (WHO-DRC) %+ Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO) %+ Eco-Anthropologie et Ethnobiologie (EAE) %+ Public Health Agency of Canada (PHAC) %+ Environnement et Risques infectieux - Environment and Infectious Risks (ERI) %+ Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC) %A Maganga, Gaël, D. %A Kapetshi, Jimmy %A Berthet, Nicolas %A Kebela Ilunga, Benoît %A Kabange, Felix %A Mbala Kingebeni, Placide %A Mondonge, Vital %A Muyembe, Jean-Jacques, T. %A Bertherat, Eric %A Briand, Sylvie %A Cabore, Joseph %A Epelboin, Alain %A Formenty, Pierre %A Kobinger, Gary %A González-Angulo, Licé %A Labouba, Ingrid %A Manuguerra, Jean-Claude %A Okwo-Bele, Jean-Marie %A Dye, Christopher %A Leroy, Eric, M. %Z Supported by Centre International de Recherches Médicales de Franceville (CIRMF), which is funded by the Gabonese government, Total Gabon, and the French Foreign Ministry; and by Metabiota, which is funded by the U.S. Department of Defense Armed Forces Health Surveillance Center, Division of Global Emerging Infections, Surveillance Operations (AFHSC GEIS), the Henry M. Jackson Foundation for the Advancement of Military Medicine, the Defense Threat Reduction Agency Cooperative Biological Engagement Program (DTRA-CBEP), Google.org, the Skoll Foundation, the U.S. Agency for International Development (USAID) Emerging Pandemic Threats Program, and the PREDICT project (cooperative agreement number GHN-A-OO-09-00010-00). %< avec comité de lecture %@ 0028-4793 %J New England Journal of Medicine %I Massachusetts Medical Society %V 371 %N 22 %P 2083-2091 %8 2014-11-27 %D 2014 %R 10.1056/NEJMoa1411099 %M 25317743 %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Microbiology and Parasitology %Z Life Sciences [q-bio]/Microbiology and Parasitology/VirologyJournal articles %X BackgroundThe seventh reported outbreak of Ebola virus disease (EVD) in the equatorial African country of the Democratic Republic of Congo (DRC) began on July 26, 2014, as another large EVD epidemic continued to spread in West Africa. Simultaneous reports of EVD in equatorial and West Africa raised the question of whether the two outbreaks were linked.MethodsWe obtained data from patients in the DRC, using the standard World Health Organization clinical-investigation form for viral hemorrhagic fevers. Patients were classified as having suspected, probable, or confirmed EVD or a non-EVD illness. Blood samples were obtained for polymerase-chain-reaction–based diagnosis, viral isolation, sequencing, and phylogenetic analysis.ResultsThe outbreak began in Inkanamongo village in the vicinity of Boende town in Équateur province and has been confined to that province. A total of 69 suspected, probable, or confirmed cases were reported between July 26 and October 7, 2014, including 8 cases among health care workers, with 49 deaths. As of October 7, there have been approximately six generations of cases of EVD since the outbreak began. The reported weekly case incidence peaked in the weeks of August 17 and 24 and has since fallen sharply. Genome sequencing revealed Ebola virus (EBOV, Zaire species) as the cause of this outbreak. A coding-complete genome sequence of EBOV that was isolated during this outbreak showed 99.2% identity with the most closely related variant from the 1995 outbreak in Kikwit in the DRC and 96.8% identity to EBOV variants that are currently circulating in West Africa.ConclusionsThe current EVD outbreak in the DRC has clinical and epidemiologic characteristics that are similar to those of previous EVD outbreaks in equatorial Africa. The causal agent is a local EBOV variant, and this outbreak has a zoonotic origin different from that in the 2014 epidemic in West Africa. (Funded by the Centre International de Recherches Médicales de Franceville and others.) %G English %Z We thank Philippe Engandja (CIRMF Gabon) and Valérie Caro and Laure Diancourt (Institut Pasteur de Paris) for their technical assistance; Ravi Santhana Gopala Krishna (WHO) and Hugh Keegan (ESRI [Environmental Systems Research Institute]) for providing the original version of the map in Figure 1; Jens H. Kuhn for assistance in the preparation of the manuscript; and Joseph Fair for continuing support. %2 https://pasteur.hal.science/pasteur-03516027/document %2 https://pasteur.hal.science/pasteur-03516027/file/nejmoa1411099.pdf %L pasteur-03516027 %U https://pasteur.hal.science/pasteur-03516027 %~ IRD %~ PASTEUR %~ MNHN %~ UNIV-PARIS7 %~ CNRS %~ ECO-AE %~ AGROPOLIS %~ B3ESTE %~ UNIV-MONTPELLIER %~ UNIV-PARIS %~ UP-SCIENCES %~ ALLIANCE-SU %~ UM-2015-2021 %~ EPI-PHYS-VIR-ONC %~ PASTEUR_UMR3569