%0 Journal Article %T Circulation of Bordetella pertussis in vaccinated Cambodian children: A transversal serological study %+ Centre de Recherche Translationnelle - Center for Translational Science (CRT) %+ Unité d'Épidémiologie et de Santé Publique [Phnom Penh] %+ Unité de biologie médicale - Medical biology unit [Phnom Penh, Cambodia] %+ Rabies Prevention Center - Centre de prévention de la rage [Phnom Penh, Cambodia] %+ Ministry of Health [Phnom Penh] %+ Direction Internationale de l'Institut Pasteur %A Noel, Gaelle %A Borand, Laurence %A Leng, Chanthy %A Keang, Chanthy %A Botr, Chhunly %A Dim, Bunnet %A Kerleguer, Alexandra %A Peng, Yik, S. %A Sreng, Navin %A Ork, Vichit %A Ait-Ahmed, Mohand %A Guiso, Nicole %A Taieb, Fabien %Z This work was supported by the Total Foundation. %< avec comité de lecture %@ 1201-9712 %J International Journal of Infectious Diseases %I Elsevier %V 106 %P 134-139 %8 2021-05 %D 2021 %R 10.1016/j.ijid.2021.03.054 %M 33766688 %K Cambodia %K Pertussis %K Sero-prevalence %K Timeliness %K Whole-cell vaccine %Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles %X Background: The Cambodia pertussis immunization schedule includes three doses given at age 6, 10 and 14 weeks using a whole-pertussis vaccine. No booster doses are included. Pertussis biological diagnosis is unavailable in Cambodia and its burden remains unclear. This study aimed to provide accurate data on pertussis serological status of Cambodian children and adolescents, and to evaluate vaccination timeliness. Methods: Fully vaccinated children aged 3-15 years were recruited at the Rabies Prevention Center, Institut Pasteur in Cambodia, Phnom Penh. Capillary blood samples and information on pertussis vaccination history were collected. Anti-pertussis toxin (PT) IgG titers were quantified by ELISA. Results: Compliance with the national immunization schedule was 95.1%. Initiation of vaccination after 8 weeks of age was observed for 29.0% of the children, but was less frequent in the youngest children (13.0%) compared with the oldest ones (46.4%). Rate of children exhibiting anti-PT IgG varied across age groups, and increased from 35.7% to 55.0% in 3-5 and 12-15 years age groups, respectively. Conclusion: Pertussis circulates among vaccinated Cambodian children and adolescents. These data support the need for public health authorities to strengthen pertussis surveillance and use local epidemiological data to make evidence-based decision for the establishment of an optimal vaccination strategy. %G English %2 https://pasteur.hal.science/pasteur-03304290/document %2 https://pasteur.hal.science/pasteur-03304290/file/1-s2.0-S1201971221002721-main.pdf %L pasteur-03304290 %U https://pasteur.hal.science/pasteur-03304290 %~ PASTEUR %~ RIIP %~ SANTE_PUB_INSERM %~ RIIP_CAMBODGE %~ TEST3-HALCNRS