%0 Journal Article %T The interplay between innate lymphoid cells and T cells %+ Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163) %+ Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)) %+ Lymphocytes et Immunité - Lymphocytes and Immunity %A Cherrier, Marie %A Ramachandran, Gayetri %A Golub, Rachel %Z M.C. is supported by INSERM and Association François Aupetit dedicated to patients suffering from IBD. R.G. work is supported by Institut Pasteur, Institut National de la Santé et de la Recherche Médicale, Université de Paris, and ANR project NASHILCCD8 (#18-CE15-0024-01). %< avec comité de lecture %@ 1933-0219 %J Mucosal Immunology %I Nature Pub. Group %8 2020-07-10 %D 2020 %R 10.1038/s41385-020-0320-8 %M 32651476 %Z Life Sciences [q-bio]/ImmunologyJournal articles %X ILCs and T cells are closely related functionally but they significantly differ in their ability to circulate, expand, and renew. Cooperation and reciprocal functional regulation suggest that these cell types are more complementary than simply redundant during immune responses. How ILCs shape T-cell responses is strongly dependent on the tissue and inflammatory context. Likewise, indirect regulation of ILCs by adaptive immunity is induced by environmental cues such as the gut microbiota. Here, we review shared requirements for the development and function of both cell types and divergences in the orchestration of prototypic immune functions. We discuss the diversity of functional interactions between T cells and ILCs during homeostasis and immune responses. Identifying the location and the nature of the tissue microenvironment in which these interactions are taking place may uncover the remaining mysteries of their close encounters. %G English %Z We thank Serge van de Pavert for critical discussions and for review of the paper. %L pasteur-02910809 %U https://pasteur.hal.science/pasteur-02910809 %~ INSERM %~ PASTEUR %~ CNRS %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ UP-SANTE %~ ANR