%0 Journal Article %T Hepatitis viruses take advantage of traditional practices to increase the burden of hepatocellular carcinoma in Tunisia %T Les virus de l'hépatite profitent des pratiques traditionnelles pour augmenter la charge du carcinome hépatocellulaire en Tunisie %+ Laboratoire de Virologie Clinique, Référence Régional OMS pour la Poliomyélite et la Rougeole - Laboratory of Clinical Virology, WHO Regional Reference Laboratory on Poliomyelitis and Measles %+ Université de Carthage (Tunisie) (UCAR) %+ Faculté des Sciences Mathématiques, Physiques et Naturelles de Tunis (FST) %+ Laboratoire d'Epidémiologie Médicale, Institut Pasteur de Tunis %+ University of Tunis El Manar %+ Hôpital La Rabta [Tunis] %+ Centre Hospitalier Universitaire Mongi Slim [La Marsa] %+ Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis %A Dhifallah, Ines %A Khedhiri, Marwa %A Chouikha, Anissa %A Kharroubi, Ghassen %A Hammami, Walid %A Sadraoui, Amel %A Azzouz, Mohamed Msaddek %A Maamouri, Nadia %A Khalfallah, Tahar %A Triki, Henda %A Pineau, Pascal %A Bahri, Olfa %Z This study was supported by the “Tunisian Secre-tariat for Scientific Research and Technology SERST for the Tunisian part of the study (LR: Epidémiologie et diversité génétique des virus hépatiques et des entérovirus, Contract: LR11SP09)” %< avec comité de lecture %@ 0304-8608 %J Archives of Virology %I Springer Verlag %V 165 %N 1 %P 33-42 %8 2020-01 %D 2020 %R 10.1007/s00705-019-04440-5 %M 31630275 %Z Life Sciences [q-bio]/Human health and pathology %Z Life Sciences [q-bio]/Cancer %Z Life Sciences [q-bio]/Microbiology and Parasitology/Virology %Z Life Sciences [q-bio]/Human health and pathology/Hépatology and GastroenterologyJournal articles %X Hepatocellular carcinoma (HCC) is a major public health issue in Africa. In Tunisia, hepatitis B virus (HBV) is known to be an important risk factor for HCC in the south of the country, but the role played by hepatitis C virus (HCV) still remains unclear. The aim of the current case-control study was to identify risk factors for HCC development in the northern part of the country. Clinical and biological data including viral hepatitis status (serological and molecular) and non-infectious risk factors from 73 patients with HCC and 70 control subjects without hepatic diseases were collected. The mean age of the patients was 63 ± 10 years, and the ratio of males to females was 1.1. HCC occurred in cirrhotic liver in 72.0% of the cases. HCV infection was the dominant risk factor (64.3% of cases); the presence of HBV was observed in 53.4% of the cases. Occult hepatitis B and C were implicated, respectively, in 30.1% and 9.6% of the cases. HCV genotype 1b was predominant. Patients originating from western Tunisia formed a homogeneous group, characterized by significantly higher rates of tattoos or scarifications (83%) and HCV infection (80%) than those from other parts of the country. Chronic HCV infection is currently the primary risk factor for HCC in Tunisia; HBV infection remains frequent in its overt or occult infection forms. Traditional esthetic practices apparently contribute to increasing the burden of terminal liver diseases in western Tunisia. %G English %L pasteur-02641737 %U https://pasteur.hal.science/pasteur-02641737 %~ PASTEUR %~ RIIP %~ RIIP_TUNIS %~ ONO-PINEAU-MARCHIO