%0 Journal Article %T The actin comet guides the way: How Listeria actin subversion has impacted cell biology, infection biology and structural biology %+ Dynamique des Interactions Hôte-Pathogène - Dynamics of Host-Pathogen Interactions %A Kühn, Sonja %A Enninga, Jost %Z This work has been supported by a postdoctoral fellowship from the Institut Pasteur to S.K. (Bourse Roux‐Cantarini) and by a grant from the ERC (CoG Endosubvert) to J.E. The Enninga team is supported by the LabEx IBEID and by the LabEx Milieu Interieur. %< avec comité de lecture %@ 1462-5814 %J Cellular Microbiology %I Wiley %V 22 %N 4 %P e13190 %8 2020-04 %D 2020 %R 10.1111/cmi.13190 %M 32185894 %K Listeria monocytogenes %K ActA %K Pascale Cossart %K actin dynamics %K nucleation promoting factor %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] %Z Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]Journal articles %X The discovery of the role of ActA to polymerise actin at one pole of Listeria monocytogenes represents a key event in the field of cellular microbiology. It uncovered much more than the molecular principle behind actin-based motility of Listeria within the cytosol of infected cells, and it changed the way how actin dynamics could be studied and eventually understood. The ActA discovery took place at a time when cell biology, biochemistry and microbiology came together in a very fruitful fashion. Here, we provide an overview of the science that took place around this event. Then, we outline the wide array of research fields that have been impacted by this finding. This ranges from structural and biophysical investigations on actin and its dynamics, the role of actin polymerisation during infection with different pathogens, to actin-dynamics during various pathologies. Like a comet in the sky, Pascale Cossart's work on ActA has inspired and will inspire generations of (life) scientists. %G English %L pasteur-02612641 %U https://pasteur.hal.science/pasteur-02612641 %~ PASTEUR %~ CNRS %~ OPENAIRE %~ ANR %~ DYNAMICS-HOST-PATHOGEN-INTERACTIONS %~ UMR3691