%0 Journal Article %T Legionella Effectors Explored with INSeq: New Functional Insights %+ Biologie des Bactéries intracellulaires - Biology of Intracellular Bacteria %A Rolando, Monica %A Buchrieser, Carmen %Z Comment on : Multiple Legionella pneumophila effector virulence phenotypes revealed through high-throughput analysis of targeted mutant libraries. [Proc Natl Acad Sci U S A. 2017] %< avec comité de lecture %@ 0966-842X %J Trends in Microbiology %I Elsevier %V 26 %N 3 %P 169-170 %8 2018-03 %D 2018 %R 10.1016/j.tim.2018.01.003 %M 29395730 %K virulence factors %K Legionella pneumophila %K bacterial effectors %K transposon insertion sequencing %Z Life Sciences [q-bio]Journal articles %X Legionella pneumophila secretes over 300 effector proteins that manipulate host cells. This multiplicity of effectors hampers the characterization of their individual roles. Shames et al. report a new approach to solve the enigma of Legionella effector function by using INSeq to analyse effector functions in the context of infection. %G English %2 https://pasteur.hal.science/pasteur-02552011/document %2 https://pasteur.hal.science/pasteur-02552011/file/2018%20Trends%20Microbiol_Rolando.pdf %L pasteur-02552011 %U https://pasteur.hal.science/pasteur-02552011 %~ PASTEUR %~ CNRS %~ UMR3525