%0 Journal Article %T Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project %+ Universität Heidelberg [Heidelberg] = Heidelberg University %+ Institute of Psychiatry, Psychology & Neuroscience, King's College London %+ Service NEUROSPIN (NEUROSPIN) %+ University Medical Center [Utrecht] %+ University of Cambridge [UK] (CAM) %+ Radboud University Medical Center [Nijmegen] %+ Donders Institute for Brain, Cognition and Behaviour %+ Karolinska Institutet [Stockholm] %+ Curtin University [Perth] %+ Goethe-University Frankfurt am Main %+ Unité Analyse et Traitement de l'Information (UNATI) %+ Centre for Brain and Cognitive Development [Birkbeck College] %+ University of Toronto %+ National Taiwan University [Taiwan] (NTU) %+ University of Cyprus [Nicosia] (UCY) %+ Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM) %+ University of Messina %+ Roche Innovation Center [Basel, Switzerland] %+ Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich) %+ Universität Zürich [Zürich] = University of Zurich (UZH) %A Moessnang, Carolin %A Baumeister, Sarah %A Tillmann, Julian %A Goyard, David %A Charman, Tony %A Ambrosino, Sara %A Baron-Cohen, Simon %A Beckmann, Christian %A Bölte, Sven %A Bours, Carsten %A Crawley, Daisy %A Dell'Acqua, Flavio %A Durston, Sarah %A Ecker, Christine %A Frouin, Vincent %A Hayward, Hannah %A Holt, Rosemary, J %A Johnson, Mark %A Jones, Emily, J %A Lai, Meng-Chuan %A Lombardo, Michael, V %A Mason, Luke %A Oldenhinkel, Marianne %A Persico, Antonio, M %A Cáceres, Antonia San José %A Spooren, Will %A Loth, Eva %A Murphy, Declan, G. %A Buitelaar, Jan %A Banaschewski, Tobias %A Brandeis, Daniel %A Tost, Heike %A Meyer-Lindenberg, Andreas %A Leap Group, Eu-Aims %Z This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777394 for the project AIMS-2-TRIALS. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA and AUTISM SPEAKS, Autistica, SFARI. Additional funding was received by the European Community’s Seventh Framework Programme under the grant agreement no. 602805 (Project EU-AGGRESSOTYPE) and no. 602450 (Project EU-IMAGEMEND), and by the German Federal Ministry of Education and Research under the grant no. 01ZX1314GM (Project IntegraMent) and grant no. 01GQ1102. C.M. is a recipient of an Olympia-Morata grant of the University Heidelberg. %< avec comité de lecture %@ 2040-2392 %J Molecular Autism %I BioMed Central %V 11 %N 1 %P 17 %8 2020-02-22 %D 2020 %R 10.1186/s13229-020-0317-x %M 32087753 %K Animated shapes %K Autism %K Autism spectrum disorder %K Development %K Mentalizing %K Multi-site %K Social brain %K Theory of mind %K fMRI %Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology %Z Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthJournal articles %X Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition with key deficits in social functioning. It is widely assumed that the biological underpinnings of social impairment are neurofunctional alterations in the "social brain," a neural circuitry involved in inferring the mental state of a social partner. However, previous evidence comes from small-scale studies and findings have been mixed. We therefore carried out the to-date largest study on neural correlates of mentalizing in ASD. Methods: As part of the Longitudinal European Autism Project, we performed functional magnetic resonance imaging at six European sites in a large, well-powered, and deeply phenotyped sample of individuals with ASD (N = 205) and typically developing (TD) individuals (N = 189) aged 6 to 30 years. We presented an animated shapes task to assess and comprehensively characterize social brain activation during mentalizing. We tested for effects of age, diagnosis, and their association with symptom measures, including a continuous measure of autistic traits. Results: We observed robust effects of task. Within the ASD sample, autistic traits were moderately associated with functional activation in one of the key regions of the social brain, the dorsomedial prefrontal cortex. However, there were no significant effects of diagnosis on task performance and no effects of age and diagnosis on social brain responses. Besides a lack of mean group differences, our data provide no evidence for meaningful differences in the distribution of brain response measures. Extensive control analyses suggest that the lack of case-control differences was not due to a variety of potential confounders. %G English %Z We thank all participants and their families for their efforts to participate in the study. Group authorship: Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian F. Beckmann, Sven Bölte, Thomas Bourgeron, Carsten Bours, Michael Brammer, Daniel Brandeis, Claudia Brogna, Yvette de Bruijn, Jan K. Buitelaar, Bhismadev Chakrabarti, Tony Charman, Ineke Cornelissen, Daisy Crawley, Flavio Dell’Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garcés, David Goyard, Lindsay Ham, Hannah Hayward, Joerg Hipp, Rosemary Holt, Mark H. Johnson, Emily J.H. Jones, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D’ardhuy, Michael V. Lombardo, Eva Loth, David J. Lythgoe, René Mandl, Andre Marquand, Luke Mason, Maarten Mennes, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Mueller, Declan G.M. Murphy, Bethany Oakley, Laurence O’Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M. Persico, Barbara Ruggeri, Amber Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Will Spooren, Julian Tillmann, Roberto Toro, Heike Tost, Jack Waldman, Steve C.R. Williams, Caroline Wooldridge, and Marcel P. Zwiers. %2 https://pasteur.hal.science/pasteur-02490559/document %2 https://pasteur.hal.science/pasteur-02490559/file/s13229-020-0317-x.pdf %L pasteur-02490559 %U https://pasteur.hal.science/pasteur-02490559 %~ PASTEUR %~ CEA %~ OPENAIRE %~ DSV %~ CEA-UPSAY %~ UNIV-PARIS-SACLAY %~ JOLIOT %~ CEA-DRF %~ NEUROSPIN %~ UNIVERSITE-PARIS-SACLAY %~ GS-ENGINEERING %~ GS-LIFE-SCIENCES-HEALTH