%0 Journal Article %T Antigen-driven focal inflammatory death of malaria liver stages %+ Biologie et Génétique du Paludisme %+ Division of Immunology [Nagasaki University] %A Bayarsaikhan, Ganchimeg %A Akbari, Masoud %A Yui, Katsuyuki %A Amino, Rogerio %Z We would like to thank our collaborators, Institut Pasteur and French National Research Agency—ANR PlasmoPEP (RA), Japan Society for the Promotion of Science (JSPS) KAKENHI grant number 25113717 (KY) and Program for Nurturing Global Leaders in Tropical and Emerging Communicable diseases of Nagasaki University (GB) for the support %< avec comité de lecture %@ 1664-302X %J Frontiers in Microbiology %I Frontiers Media %V 6 %P 47 %8 2015-02-04 %D 2015 %R 10.3389/fmicb.2015.00047 %M 25699034 %K in vivo imaging %K inflammatory infiltrate %K CD8+ T cells %K Plasmodium %K cooperative behavior %Z Life Sciences [q-bio]/Immunology/Adaptive immunologyJournal articles %X Multiple immunizations using live irradiated sporozoites, the infectious plasmodial stage delivered into the host skin during a mosquito bite, can elicit sterile immunity to malaria. CD8(+) T cells seem to play an essential role in this protective immunity, since their depletion consistently abolishes sterilizing protection in several experimental models. So far, only a few parasite antigens are known to induce CD8(+) T cell-dependent protection, but none of them can reach the levels of protection afforded by live attenuated parasites. Systematic attempts to identify novel antigens associated with this efficient cellular protection were so far unsuccessful. In addition, the precise mechanisms involved in the recognition and elimination of parasitized hepatocytes in vivo by CD8(+) T cells still remain obscure. Recently, it has been shown that specific effector CD8(+) T cells, after recognition of parasitized hepatocytes, recruit specific and non-specific activated CD8(+) T cells to the site of infection, resulting in the formation of cellular clusters around and in the further elimination of intracellular parasites. The significance of this finding is discussed in the perspective of a general mechanism of antigen-dependent focalized inflammation and its consequences for the elimination of malaria liver stages. %G English %Z We thank Robert Menard for critically reading the manuscript. We also apologize for all colleagues whose work was not cited here due to space limitations or unawareness. %2 https://pasteur.hal.science/pasteur-02425472/document %2 https://pasteur.hal.science/pasteur-02425472/file/Antigen-driven_focal_inflammatory_death_of_malaria_liver_stages.pdf %L pasteur-02425472 %U https://pasteur.hal.science/pasteur-02425472 %~ PASTEUR