%0 Journal Article %T H-2D b/ Mice Are Susceptible to Persistent Infection by Theiler's Virus %+ Virus Lents %+ Immunité Cellulaire Antivirale %A Azoulay-Cayla, Arièle %A Dethlefs, Sven %A Pérarnau, Béatrice %A Larsson-Sciard, Eva-Lotta %A Lemonnier, François, A %A Brahic, Michel %A Bureau, Jean-François %Z Arièle Azoulay-Cayla was supported by fellowships from the Association pour la Recherche sur la Sclérose en Plaques and the Fondation pour la Recherche Médicale. Research on Theiler's virus in the Unité des Virus Lents is supported by grants from Institut Pasteur, CNRS, the Association pour la Recherche sur la Sclérose en Plaques, and the National Multiple Sclerosis Society, United States. %< avec comité de lecture %@ 0022-538X %J Journal of Virology %I American Society for Microbiology %V 74 %N 12 %P 5470 - 5476 %8 2000-06 %D 2000 %R 10.1128/JVI.74.12.5470-5476.2000 %M 10823851 %Z Life Sciences [q-bio]/Genetics/Animal genetics %Z Life Sciences [q-bio]/Microbiology and Parasitology/VirologyJournal articles %X H-2 b mice are resistant to persistent infection of the central nervous system by Theiler's virus. They clear the infection 7 to 10 days after intracranial inoculation. Resistance maps to the H-2D gene and not to the H-2K gene and is associated with a potent antiviral cytotoxic T-lymphocyte (CTL) response. We used H-2 b mice in which the H-2D or the H-2K gene had been inactivated to dissect the respective roles of these genes in resistance. We report that H-2D / but not H-2K / mice were susceptible to persistent infection. Furthermore , whereas H-2K / mice mounted a vigorous virus-specific CTL response, similar to that of control C57BL/6 mice, the CTL response of H-2D / mice was nil or minimal. Using target cells transfected with the H-2D b or the H-2K b gene, we showed that the H-2K-restricted CTL response against the virus was minimal in H-2D / mice. These results demonstrate that the H-2D b and H-2K b genes play nonredundant roles in the resistance to this persistent infection. %G English %Z We thank Sylvie Syan for excellent technical assistance and Mireille Gau for secretarial help. %L pasteur-02097150 %U https://pasteur.hal.science/pasteur-02097150 %~ PASTEUR %~ CNRS %~ FRM