%0 Journal Article %T Cytoplasmic Intermediate Filaments in Cell Biology %+ Polarité cellulaire, Migration et Cancer - Cell Polarity, Migration and Cancer %A Etienne-Manneville, Sandrine %Z This work was supported by La Ligue Nationale Contre le Cancer, the Centre National pour la Recherche, and the Institut Pasteur. %< avec comité de lecture %@ 1081-0706 %J Annual Review of Cell and Developmental Biology %I Annual Reviews %V 34 %N 1 %P 1 - 28 %8 2018 %D 2018 %R 10.1146/annurev-cellbio-100617- %M 30059630 %K cell mechanics %K cell adhesion %K keratin %K vimentin %K GFAP %K nestin %K neurofilaments %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Cellular BiologyJournal articles %X Intermediate filaments (IFs) are one of the three major elements of the cy-toskeleton. Their stability, intrinsic mechanical properties, and cell type-specific expression patterns distinguish them from actin and microtubules. By providing mechanical support, IFs protect cells from external forces and participate in cell adhesion and tissue integrity. IFs form an extensive and elaborate network that connects the cell cortex to intracellular organelles. They act as a molecular scaffold that controls intracellular organization. However, IFs have been revealed as much more than just rigid structures. Their dynamics is regulated by multiple signaling cascades and appears to contribute to signaling events in response to cell stress and to dynamic cellular functions such as mitosis, apoptosis, and migration. %G English %Z I thank Jean-Baptiste Manneville and Shailaja Seetharaman for stimulating discussions and careful reading of the manuscript. I apologize to our colleagues whose work could not be cited due to space limitations. %L pasteur-02057760 %U https://pasteur.hal.science/pasteur-02057760 %~ PASTEUR %~ CNRS %~ CELL-POLARITY-MIGRATION-CANCER %~ UMR3691