%0 Journal Article %T Establishment of the European meningococcal strain collection genome library (EMSC-GL) for the 2011 to 2012 epidemiological year. %+ University of Oxford %+ National University of Ireland [Galway] (NUI Galway) %+ Austrian Agency for Health and Food Safety (AGES) %+ Nicosia General Hospital %+ National Institute of Public Health [Prague] %+ Statens Serum Institut [Copenhagen] %+ National Institute of Public Health and Welfare [Helsinki] %+ Institut Pasteur [Paris] (IP) %+ Julius-Maximilians-Universität Würzburg (JMU) %+ National Meningitis Reference Laboratory %+ National Center for Epidemiology - Országos Epidemiológiai Központ [Budapest] (OEK) %+ Riga East University Hospital %+ University of Amsterdam [Amsterdam] (UvA) %+ National Medicines Institute - Narodowy Instytut Leków [Warsaw] (NIL) %+ National Institute of Research and Development for Microbiology and Immunology [Bucharest] %+ Public Health Authority of the Slovak Republic %+ National Institute of Public Health of the Republic of Slovenia %+ Norwegian Institute of Public Health [Oslo] (NIPH) %A Bratcher, Holly B. %A Brehony, Carina %A Heuberger, Sigrid %A Pieridou-Bagatzouni, Despo %A Křížová, Pavla %A Hoffmann, Steen %A Toropainen, Maija %A Taha, Muhamed-Kheir %A Claus, Heike %A Tzanakaki, Georgina %A Erdôsi, Tímea %A Galajeva, Jelena %A van Der Ende, Arie %A Skoczyńska, Anna %A Pana, Marina %A Vaculíková, Alena %A Paragi, Metka %A Maiden, Martin Cj %A Caugant, Dominique, A %Z The project was funded by the ECDC within the framework of the IBD-labnet program through the Specific Contract No3 ECD.4051 implementing Framework Contract No ECDC/2011/014.Database curators are currently supported by the UK Department of Health (grant H2R00080).This publication made use of the Neisseria Multi Locus Sequence Typing website (https://pubmlst.org/neisseria/) developed by Keith Jolley and sited at the University of Oxford (Jolley & Maiden 2010, BMC Bioinformatics, 11:595). The development of this site has been funded by the Wellcome Trust and European Union, Wellcome Trust Biomedical Resource Grant (104992). %< avec comité de lecture %@ 1560-7917 %J Eurosurveillance %I European Centre for Disease Prevention and Control %V 23 %N 20 %8 2018-05-17 %D 2018 %R 10.2807/1560-7917.ES.2018.23.20.17-00474 %M 29790460 %K monitor vaccine coverage %K surveillance %K track antimicrobial susceptibility %K genome library %K Neisseria meningitidis %Z Life Sciences [q-bio]/Santé publique et épidémiologie %Z Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyJournal articles %X Invasive meningococcal disease surveillance in Europe combines isolate characterisation and epidemiological data to support public health intervention. A representative European Meningococcal Strain Collection (EMSC) of IMD isolates was obtained, and whole genome sequenced to characterise 799 EMSC isolates from the epidemiological year July 2011-June 2012. To establish a genome library (GL), the isolate information was deposited in the pubMLST.org/neisseria database. Genomes were curated and annotated at 2,429 meningococcal loci, including those defining clonal complex, capsule, antigens, and antimicrobial resistance. Most genomes contained genes encoding B (n = 525; 65.7%) or C (n = 163; 20.4%) capsules; isolates were genetically highly diverse, with >20 genomic lineages, five of which comprising 60.7% (n = 485) of isolates. There were >350 antigenic fine-types: 307 were present once, the most frequent (P1.7-2,4:F5-1) comprised 8% (n = 64) of isolates. Each genome was characterised for Bexsero Antigen Sequence Typing (BAST): 25.5% (n = 204) of isolates contained alleles encoding the fHbp and/or the PorA VR1 vaccine component, but most genomes (n = 513; 64.2%) did not contain the NadA component. EMSC-GL will support an integrated surveillance of disease-associated genotypes in Europe, enabling the monitoring of hyperinvasive lineages, outbreak identification, and supporting vaccine programme implementation. %G English %2 https://pasteur.hal.science/pasteur-02013211/document %2 https://pasteur.hal.science/pasteur-02013211/file/eurosurv-23-20-3.pdf %L pasteur-02013211 %U https://pasteur.hal.science/pasteur-02013211 %~ PASTEUR %~ SANTE_PUB_INSERM