%0 Journal Article %T A convergent functional architecture of the insula emerges across imaging modalities %+ New York University [New York] (NYU) %+ Génétique Humaine et Fonctions Cognitives %+ Centre de recherche de l'Institut universitaire de gériatrie de Montreal (CRIUGM) %+ Nathan S. Kline Institute for Psychiatric Research (NKI) %+ Child Mind Institute %A Kelly, Clare %A Toro, Roberto %A Di Martino, Adriana %A Cox, Christine, L %A Bellec, Pierre %A Castellanos, F. Xavier %A Milham, Michael %Z This work was supported by grants from the National Institute on Drug Abuse (R03DA024775 to CK, 2T32DA007254-16A2 to CLC and R01DA016979 to FXC), the National Institute of Mental Health (R01MH083246 and R01MH081218 to FXC and MPM; K23MH087770 to ADM), the National Institute of Child Health and Human Development (R01HD065282 to FXC), the Leon Levy Foundation (ADM, CK and MPM), as well as Autism Speaks, the Stavros Niarchos Foundation, and the Alicia Koplowitz Foundation (FXC). %< avec comité de lecture %@ 1053-8119 %J NeuroImage %I Elsevier %V 61 %N 4 %P 1129-1142 %8 2012-07-16 %D 2012 %R 10.1016/j.neuroimage.2012.03.021 %M 22440648 %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Journal articles %X Empirical evidence increasingly supports the hypothesis that patterns of intrinsic functional connectivity (iFC) are sculpted by a history of evoked coactivation within distinct neuronal networks. This, together with evidence of strong correspondence among the networks defined by iFC and those delineated using a variety of other neuroimaging techniques, suggests a fundamental brain architecture detectable across multiple functional and structural imaging modalities. Here, we leverage this insight to examine the functional organization of the human insula. We parcellated the insula on the basis of three distinct neuroimaging modalities task evoked coactivation, intrinsic (i.e., task-independent) functional connectivity, and gray matter structural covariance. Clustering of these three different covariance-based measures revealed a convergent elemental organization of the insula that likely reflects a fundamental brain architecture governing both brain structure and function at multiple spatial scales. While not constrained to be hierarchical, our parcella-tion revealed a pseudo-hierarchical, multiscale organization that was consistent with previous clustering and meta-analytic studies of the insula. Finally, meta-analytic examination of the cognitive and behavioral domains associated with each of the insular clusters obtained elucidated the broad functional dissociations likely underlying the topography observed. To facilitate future investigations of insula function across healthy and pathological states, the insular parcels have been made freely available for download via http:// fcon_1000.projects.nitrc.org, along with the analytic scripts used to perform the parcellations. %G English %L pasteur-01967153 %U https://pasteur.hal.science/pasteur-01967153 %~ PASTEUR %~ CNRS %~ UP-SCIENCES