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            <funder>This study was supported by the Li Ka Shing Foundation-University of Oxford Global Health Programme 2007–2010, PathoQuest (convention 04-12), and the Institut Microbiology and Maladies Infectieuses (IMMI NO 201103).</funder>
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                <title level="j">Emerging microbes &amp; infections</title>
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                <term xml:lang="en">chikungunya virus</term>
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                <term xml:lang="en">encephalitis</term>
                <term xml:lang="en">Japanese encephalitis virus</term>
                <term xml:lang="en">meningoencephalitis</term>
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              <classCode scheme="mesh">Acute Disease</classCode>
              <classCode scheme="mesh">Adolescent</classCode>
              <classCode scheme="mesh">Encephalitis Virus, Japanese</classCode>
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              <p>Acute meningoencephalitis (AME) is associated with considerable morbidity and mortality in children in developing countries. Clinical specimens were collected from children presenting with AME at two Cambodian paediatric hospitals to determine the major aetiologies associated with AME in the country. Cerebrospinal fluid (CSF) and blood samples were screened by molecular and cell culture methods for a range of pathogens previously associated with AME in the region. CSF and serum (acute and convalescent) were screened for antibodies to arboviruses such as Japanese encephalitis virus (JEV), dengue virus (DENV), and chikungunya virus (CHIKV). From July 2010 through December 2013, 1160 children (one month to 15 years of age) presenting with AME to two major paediatric hospitals were enroled into the study. Pathogens associated with AME were identified using molecular diagnostics, cell culture and serology. According to a diagnostic algorithm, a confirmed or highly probable aetiologic agent was detected in 35.0% (n=406) of AME cases, with a further 9.2% (total: 44.2%, n=513) aetiologies defined as suspected. JEV (24.4%, n=283) was the most commonly identified pathogen followed by Orientia tsutsugamushi (4.7%, n=55), DENV (4.6%, n=53), enteroviruses (3.5%, n=41), CHIKV (2.0%, n=23) and Streptococcus pneumoniae (1.6%, n=19). The majority of aetiologies identified for paediatric AME in Cambodia were vaccine preventable and/or treatable with appropriate antimicrobials.</p>
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