<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of pasteur-01392630</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-07T03:41:11+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Evidence of innate lymphoid cell redundancy in humans</title>
            <author role="aut">
              <persName>
                <forename type="first">Frédéric</forename>
                <surname>Vély</surname>
              </persName>
              <idno type="halauthorid">221010-0</idno>
              <affiliation ref="#struct-458410"/>
              <affiliation ref="#struct-182245"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincent</forename>
                <surname>Barlogis</surname>
              </persName>
              <idno type="idhal" notation="numeric">762453</idno>
              <idno type="halauthorid" notation="string">450658-762453</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9645-3968</idno>
              <idno type="IDREF">https://www.idref.fr/108920046</idno>
              <affiliation ref="#struct-458700"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Blandine</forename>
                <surname>Vallentin</surname>
              </persName>
              <idno type="halauthorid">1077644-0</idno>
              <affiliation ref="#struct-458700"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bénédicte</forename>
                <surname>Neven</surname>
              </persName>
              <email type="md5">d57319209463da82cba6c38dfe545161</email>
              <email type="domain">nck.aphp.fr</email>
              <idno type="idhal" notation="numeric">1184780</idno>
              <idno type="halauthorid" notation="string">154764-1184780</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8941-0935</idno>
              <affiliation ref="#struct-80990"/>
              <affiliation ref="#struct-247401"/>
              <affiliation ref="#struct-19365"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christelle</forename>
                <surname>Piperoglou</surname>
              </persName>
              <idno type="halauthorid">1077645-0</idno>
              <affiliation ref="#struct-458410"/>
              <affiliation ref="#struct-182245"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mikael</forename>
                <surname>Ebbo</surname>
              </persName>
              <idno type="halauthorid">685481-0</idno>
              <affiliation ref="#struct-458410"/>
              <affiliation ref="#struct-182245"/>
              <affiliation ref="#struct-417872"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thibaut</forename>
                <surname>Perchet</surname>
              </persName>
              <idno type="halauthorid">1009518-0</idno>
              <affiliation ref="#struct-453291"/>
              <affiliation ref="#struct-415981"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Maxime</forename>
                <surname>Petit</surname>
              </persName>
              <email type="md5">d10b2cd38b7812f9bce71be182a1a4e1</email>
              <email type="domain">sorbonne-universite.fr</email>
              <idno type="idhal" notation="string">maxime-p</idno>
              <idno type="idhal" notation="numeric">753535</idno>
              <idno type="halauthorid" notation="string">41543-753535</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8443-1531</idno>
              <affiliation ref="#struct-453291"/>
              <affiliation ref="#struct-415981"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nadia</forename>
                <surname>Yessaad</surname>
              </persName>
              <idno type="halauthorid">573995-0</idno>
              <affiliation ref="#struct-442972"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabien</forename>
                <surname>Touzot</surname>
              </persName>
              <idno type="idhal" notation="numeric">762697</idno>
              <idno type="halauthorid" notation="string">465061-762697</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0889-4905</idno>
              <affiliation ref="#struct-247401"/>
              <affiliation ref="#struct-414766"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Julie</forename>
                <surname>Bruneau</surname>
              </persName>
              <idno type="halauthorid">726318-0</idno>
              <affiliation ref="#struct-247401"/>
              <affiliation ref="#struct-414766"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicolas</forename>
                <surname>Zucchini</surname>
              </persName>
              <idno type="halauthorid">322080-0</idno>
              <affiliation ref="#struct-103388"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nizar</forename>
                <surname>Mahlaoui</surname>
              </persName>
              <idno type="halauthorid">573829-0</idno>
              <affiliation ref="#struct-80990"/>
              <affiliation ref="#struct-247401"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Farnarier</surname>
              </persName>
              <idno type="halauthorid">479251-0</idno>
              <affiliation ref="#struct-417872"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gérard</forename>
                <surname>Michel</surname>
              </persName>
              <idno type="halauthorid">197336-0</idno>
              <affiliation ref="#struct-458700"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Despina</forename>
                <surname>Moshous</surname>
              </persName>
              <email type="md5">dfe98c971ae742025648844f81bd2fb2</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">despina-moshous</idno>
              <idno type="idhal" notation="numeric">1187483</idno>
              <idno type="halauthorid" notation="string">154647-1187483</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6719-3693</idno>
              <affiliation ref="#struct-80990"/>
              <affiliation ref="#struct-247401"/>
              <affiliation ref="#struct-19365"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arnaud</forename>
                <surname>Dujardin</surname>
              </persName>
              <idno type="halauthorid">745897-0</idno>
              <affiliation ref="#struct-111290"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stéphane</forename>
                <surname>Blanche</surname>
              </persName>
              <idno type="halauthorid">117446-0</idno>
              <affiliation ref="#struct-80990"/>
              <affiliation ref="#struct-247401"/>
              <affiliation ref="#struct-19365"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hergen</forename>
                <surname>Spits</surname>
              </persName>
              <idno type="halauthorid">409034-0</idno>
              <affiliation ref="#struct-112034"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jörg H W</forename>
                <surname>Distler</surname>
              </persName>
              <idno type="halauthorid">626419-0</idno>
              <affiliation ref="#struct-311714"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Andreas</forename>
                <surname>Ramming</surname>
              </persName>
              <idno type="halauthorid">1077646-0</idno>
              <affiliation ref="#struct-311714"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Capucine</forename>
                <surname>Picard</surname>
              </persName>
              <idno type="idhal" notation="numeric">758297</idno>
              <idno type="halauthorid" notation="string">218445-758297</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8788-5056</idno>
              <idno type="IDREF">https://www.idref.fr/091572363</idno>
              <affiliation ref="#struct-80990"/>
              <affiliation ref="#struct-247401"/>
              <affiliation ref="#struct-19365"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rachel</forename>
                <surname>Golub</surname>
              </persName>
              <idno type="halauthorid">363046-0</idno>
              <affiliation ref="#struct-453291"/>
              <affiliation ref="#struct-415981"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Alain</forename>
                <surname>Fischer</surname>
              </persName>
              <email type="md5">88be9a1211e76266b25c9e5169757b2a</email>
              <email type="domain">college-de-france.fr</email>
              <idno type="idhal" notation="numeric">832560</idno>
              <idno type="halauthorid" notation="string">132274-832560</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4025-5983</idno>
              <idno type="IDREF">https://www.idref.fr/060735457</idno>
              <affiliation ref="#struct-80990"/>
              <affiliation ref="#struct-247401"/>
              <affiliation ref="#struct-19365"/>
              <affiliation ref="#struct-1043610"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Eric</forename>
                <surname>Vivier</surname>
              </persName>
              <email type="md5">5bfb77e73d4fd86616173673fdef6ee1</email>
              <email type="domain">ciml.univ-mrs.fr</email>
              <idno type="idhal" notation="string">eric-vivier</idno>
              <idno type="idhal" notation="numeric">17342</idno>
              <idno type="halauthorid" notation="string">32004-17342</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-8939-2010</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7022-8287</idno>
              <idno type="IDREF">https://www.idref.fr/076121712</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=NlmFOgMAAAAJ</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-8939-2010</idno>
              <affiliation ref="#struct-458410"/>
              <affiliation ref="#struct-182245"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Despina</forename>
                <surname>Moshous</surname>
              </persName>
              <email type="md5">dfe98c971ae742025648844f81bd2fb2</email>
              <email type="domain">inserm.fr</email>
            </editor>
            <funder>We thank all patients and their families for participating in the study; C. Bonnafous and N. Anceriz (Innate-Pharma) for monoclonal antibody to NKp46; F. Suarez (Paris), N. Schleinitz (Marseille) and Y. Bertrand (Lyon) for enrolling patients in the study; and the Laboratory of Hematology (P.E. Morange, Marseille) for sample storage. Supported by the European Research Council (THINK Advanced Grant for the E.V. laboratory), the Ligue Nationale contre le Cancer (Equipe Labellisée; E.V. laboratory), institutional grants from INSERM, CNRS and Aix-Marseille University to CIML (E.V. laboratory), the Institut Universitaire de France (E.V.), the European Research Council (Pidimmune Advanced Grant for the A.F. laboratory), institutional grants from INSERM, Paris Descartes University and Collège de France (A.F. laboratory), Investissements d’Avenir Instituts Hospitaliers Universitaires (A.F. laboratory), institutional grants from Institut Pasteur, INSERM, Université Paris Diderot and the Agence Nationale de la Recherche (“Myeloten”; R.G. group), the Institut National du Cancer (R.G. group) and Université Sorbonne Paris Cité (“Mucocell”; R.G. group)</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-10-14 23:04:49</date>
              <date type="whenModified">2026-05-07 03:23:20</date>
              <date type="whenReleased">2024-10-15 11:36:42</date>
              <date type="whenProduced">2016-11</date>
              <date type="whenEndEmbargoed">2024-10-14</date>
              <ref type="file" target="https://pasteur.hal.science/pasteur-01392630v1/document">
                <date notBefore="2024-10-14"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://pasteur.hal.science/pasteur-01392630v1/file/main.pdf" id="file-4736475-4124450">
                <date notBefore="2024-10-14"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074366"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="182543">
                <persName>
                  <forename>Despina</forename>
                  <surname>Moshous</surname>
                </persName>
                <email type="md5">dfe98c971ae742025648844f81bd2fb2</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">pasteur-01392630</idno>
            <idno type="halUri">https://pasteur.hal.science/pasteur-01392630</idno>
            <idno type="halBibtex">vely:pasteur-01392630</idno>
            <idno type="halRefHtml">&lt;i&gt;Nature Immunology&lt;/i&gt;, 2016, 17 (11), pp.1291 - 1299. &lt;a target="_blank" href="https://dx.doi.org/10.1038/ni.3553"&gt;&amp;#x27E8;10.1038/ni.3553&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Nature Immunology, 2016, 17 (11), pp.1291 - 1299. &amp;#x27E8;10.1038/ni.3553&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-4736475-4124450"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="PASTEUR">Institut Pasteur</idno>
            <idno type="stamp" n="UNIV-PARIS5" corresp="UNIV-PARIS">Université Paris Descartes (Paris 5)</idno>
            <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="CDF">Collège de France</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
            <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno>
            <idno type="stamp" n="CERCLE">Publications des lauréats des projets ERC financés sur le site Aix Marseille</idno>
            <idno type="stamp" n="CHU-UNIV-PARIS5">Les centres hospitaliers de Paris Descartes</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="CDF-PSL" corresp="PSL">Collège de France - PSL </idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES" corresp="ACADEMIE-SCIENCES">Publications des membres, correspondants et associés étrangers de l'Académie des sciences</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES-1" corresp="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES">Publications des membres de l'Académie des sciences (lot 1)</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Evidence of innate lymphoid cell redundancy in humans</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Frédéric</forename>
                    <surname>Vély</surname>
                  </persName>
                  <idno type="halauthorid">221010-0</idno>
                  <affiliation ref="#struct-458410"/>
                  <affiliation ref="#struct-182245"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincent</forename>
                    <surname>Barlogis</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">762453</idno>
                  <idno type="halauthorid" notation="string">450658-762453</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9645-3968</idno>
                  <idno type="IDREF">https://www.idref.fr/108920046</idno>
                  <affiliation ref="#struct-458700"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Blandine</forename>
                    <surname>Vallentin</surname>
                  </persName>
                  <idno type="halauthorid">1077644-0</idno>
                  <affiliation ref="#struct-458700"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bénédicte</forename>
                    <surname>Neven</surname>
                  </persName>
                  <email type="md5">d57319209463da82cba6c38dfe545161</email>
                  <email type="domain">nck.aphp.fr</email>
                  <idno type="idhal" notation="numeric">1184780</idno>
                  <idno type="halauthorid" notation="string">154764-1184780</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8941-0935</idno>
                  <affiliation ref="#struct-80990"/>
                  <affiliation ref="#struct-247401"/>
                  <affiliation ref="#struct-19365"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christelle</forename>
                    <surname>Piperoglou</surname>
                  </persName>
                  <idno type="halauthorid">1077645-0</idno>
                  <affiliation ref="#struct-458410"/>
                  <affiliation ref="#struct-182245"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mikael</forename>
                    <surname>Ebbo</surname>
                  </persName>
                  <idno type="halauthorid">685481-0</idno>
                  <affiliation ref="#struct-458410"/>
                  <affiliation ref="#struct-182245"/>
                  <affiliation ref="#struct-417872"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thibaut</forename>
                    <surname>Perchet</surname>
                  </persName>
                  <idno type="halauthorid">1009518-0</idno>
                  <affiliation ref="#struct-453291"/>
                  <affiliation ref="#struct-415981"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Maxime</forename>
                    <surname>Petit</surname>
                  </persName>
                  <email type="md5">d10b2cd38b7812f9bce71be182a1a4e1</email>
                  <email type="domain">sorbonne-universite.fr</email>
                  <idno type="idhal" notation="string">maxime-p</idno>
                  <idno type="idhal" notation="numeric">753535</idno>
                  <idno type="halauthorid" notation="string">41543-753535</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8443-1531</idno>
                  <affiliation ref="#struct-453291"/>
                  <affiliation ref="#struct-415981"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nadia</forename>
                    <surname>Yessaad</surname>
                  </persName>
                  <idno type="halauthorid">573995-0</idno>
                  <affiliation ref="#struct-442972"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabien</forename>
                    <surname>Touzot</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">762697</idno>
                  <idno type="halauthorid" notation="string">465061-762697</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0889-4905</idno>
                  <affiliation ref="#struct-247401"/>
                  <affiliation ref="#struct-414766"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Julie</forename>
                    <surname>Bruneau</surname>
                  </persName>
                  <idno type="halauthorid">726318-0</idno>
                  <affiliation ref="#struct-247401"/>
                  <affiliation ref="#struct-414766"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicolas</forename>
                    <surname>Zucchini</surname>
                  </persName>
                  <idno type="halauthorid">322080-0</idno>
                  <affiliation ref="#struct-103388"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nizar</forename>
                    <surname>Mahlaoui</surname>
                  </persName>
                  <idno type="halauthorid">573829-0</idno>
                  <affiliation ref="#struct-80990"/>
                  <affiliation ref="#struct-247401"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Farnarier</surname>
                  </persName>
                  <idno type="halauthorid">479251-0</idno>
                  <affiliation ref="#struct-417872"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gérard</forename>
                    <surname>Michel</surname>
                  </persName>
                  <idno type="halauthorid">197336-0</idno>
                  <affiliation ref="#struct-458700"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Despina</forename>
                    <surname>Moshous</surname>
                  </persName>
                  <email type="md5">dfe98c971ae742025648844f81bd2fb2</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">despina-moshous</idno>
                  <idno type="idhal" notation="numeric">1187483</idno>
                  <idno type="halauthorid" notation="string">154647-1187483</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6719-3693</idno>
                  <affiliation ref="#struct-80990"/>
                  <affiliation ref="#struct-247401"/>
                  <affiliation ref="#struct-19365"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arnaud</forename>
                    <surname>Dujardin</surname>
                  </persName>
                  <idno type="halauthorid">745897-0</idno>
                  <affiliation ref="#struct-111290"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stéphane</forename>
                    <surname>Blanche</surname>
                  </persName>
                  <idno type="halauthorid">117446-0</idno>
                  <affiliation ref="#struct-80990"/>
                  <affiliation ref="#struct-247401"/>
                  <affiliation ref="#struct-19365"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hergen</forename>
                    <surname>Spits</surname>
                  </persName>
                  <idno type="halauthorid">409034-0</idno>
                  <affiliation ref="#struct-112034"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jörg H W</forename>
                    <surname>Distler</surname>
                  </persName>
                  <idno type="halauthorid">626419-0</idno>
                  <affiliation ref="#struct-311714"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Andreas</forename>
                    <surname>Ramming</surname>
                  </persName>
                  <idno type="halauthorid">1077646-0</idno>
                  <affiliation ref="#struct-311714"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Capucine</forename>
                    <surname>Picard</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">758297</idno>
                  <idno type="halauthorid" notation="string">218445-758297</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8788-5056</idno>
                  <idno type="IDREF">https://www.idref.fr/091572363</idno>
                  <affiliation ref="#struct-80990"/>
                  <affiliation ref="#struct-247401"/>
                  <affiliation ref="#struct-19365"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rachel</forename>
                    <surname>Golub</surname>
                  </persName>
                  <idno type="halauthorid">363046-0</idno>
                  <affiliation ref="#struct-453291"/>
                  <affiliation ref="#struct-415981"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Alain</forename>
                    <surname>Fischer</surname>
                  </persName>
                  <email type="md5">88be9a1211e76266b25c9e5169757b2a</email>
                  <email type="domain">college-de-france.fr</email>
                  <idno type="idhal" notation="numeric">832560</idno>
                  <idno type="halauthorid" notation="string">132274-832560</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4025-5983</idno>
                  <idno type="IDREF">https://www.idref.fr/060735457</idno>
                  <affiliation ref="#struct-80990"/>
                  <affiliation ref="#struct-247401"/>
                  <affiliation ref="#struct-19365"/>
                  <affiliation ref="#struct-1043610"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Eric</forename>
                    <surname>Vivier</surname>
                  </persName>
                  <email type="md5">5bfb77e73d4fd86616173673fdef6ee1</email>
                  <email type="domain">ciml.univ-mrs.fr</email>
                  <idno type="idhal" notation="string">eric-vivier</idno>
                  <idno type="idhal" notation="numeric">17342</idno>
                  <idno type="halauthorid" notation="string">32004-17342</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-8939-2010</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7022-8287</idno>
                  <idno type="IDREF">https://www.idref.fr/076121712</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=NlmFOgMAAAAJ</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-8939-2010</idno>
                  <affiliation ref="#struct-458410"/>
                  <affiliation ref="#struct-182245"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">17319</idno>
                <idno type="issn">1529-2908</idno>
                <idno type="eissn">1529-2916</idno>
                <title level="j">Nature Immunology</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">17</biblScope>
                  <biblScope unit="issue">11</biblScope>
                  <biblScope unit="pp">1291 - 1299</biblScope>
                  <date type="datePub">2016-11</date>
                  <date type="dateEpub">2016-09-12</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/ni.3553</idno>
              <idno type="pubmed">27618553</idno>
              <idno type="pubmedcentral">PMC5074366</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.imm">Life Sciences [q-bio]/Immunology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Innate lymphoid cells (ILCs) have potent immunological functions in experimental conditions in mice, but their contributions to immunity in natural conditions in humans have remained unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in patients with SCID who had mutation of the gene encoding the common γ-chain cytokine receptor subunit IL-2Rγ or the gene encoding the tyrosine kinase JAK3. T cell reconstitution was observed in patients with SCID after hematopoietic stem cell transplantation (HSCT), but the patients still had considerably fewer ILCs in the absence of myeloablation than did healthy control subjects, with the exception of rare cases of reconstitution of the ILC1 subset of ILCs. Notably, the ILC deficiencies observed were not associated with any particular susceptibility to disease, with follow-up extending from 7 years to 39 years after HSCT. We thus report here selective ILC deficiency in humans and show that ILCs might be dispensable in natural conditions, if T cells are present and B cell function is preserved.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-458410" status="VALID">
          <orgName>Laboratoire d'Immunologie [Hôpital de la Conception - APHM]</orgName>
          <desc>
            <address>
              <addrLine>147, boulevard Baille 13385 Marseille cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/service/laboratoire-immunologie-hopital-conception</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300073" type="direct"/>
            <relation active="#struct-303623" type="direct"/>
            <relation active="#struct-417872" type="direct"/>
            <relation active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-182245" status="VALID">
          <idno type="IdRef">150044909</idno>
          <idno type="RNSR">200017461J</idno>
          <idno type="ROR">03vyjkj45</idno>
          <orgName>Centre d'Immunologie de Marseille - Luminy</orgName>
          <orgName type="acronym">CIML</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UM 2" active="#struct-198056" type="direct"/>
            <relation name="UMR_S 1104" active="#struct-303623" type="direct"/>
            <relation name="UMR7280" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-458700" status="VALID">
          <orgName>Pédiatrie et oncologie pédiatrique  [Hôpital de la Timone - APHM]</orgName>
          <desc>
            <address>
              <addrLine>264 Rue Saint-Pierre, 13385 Marseille</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-198056" type="direct"/>
            <relation active="#struct-300073" type="direct"/>
            <relation active="#struct-300093" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-80990" status="VALID">
          <orgName>Centre de Référence Déficits Immunitaires Héréditaires</orgName>
          <orgName type="acronym">CEREDIH</orgName>
          <desc>
            <address>
              <addrLine>149, rue de Sevres 75015 PARIS</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ceredih.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-414766" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-247401" status="OLD">
          <idno type="IdRef">188538119</idno>
          <idno type="ISNI">0000 0004 0620 6624</idno>
          <idno type="RNSR">201420829J</idno>
          <idno type="ROR">https://ror.org/04z4fen17</idno>
          <orgName>Imagine - Institut des maladies génétiques</orgName>
          <orgName type="acronym">IMAGINE - U1163</orgName>
          <date type="start">2014-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>IHU Imagine, 156 rue de Vaugirard, 75015 PARIS et 24 Boulevard du Montparnasse, 75015 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.institutimagine.org/fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR_S 1163" active="#struct-301664" type="direct"/>
            <relation name="U1163" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-19365" status="VALID">
          <orgName>Service d'immuno-hématologie pédiatrique [CHU Necker]</orgName>
          <desc>
            <address>
              <addrLine>149 Rue de Sèvres, 75015 Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-414766" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-417872" status="VALID">
          <idno type="ISNI">0000 0004 0638 9491 </idno>
          <idno type="ROR">https://ror.org/00s7v8q53</idno>
          <orgName>Hôpital de la Conception [CHU - APHM]</orgName>
          <orgName type="acronym">LA CONCEPTION</orgName>
          <date type="start">1985-01-01</date>
          <desc>
            <address>
              <addrLine>147 Boulevard Baille 13005 Marseille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-conception</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-453291" status="OLD">
          <idno type="RNSR">201121870D</idno>
          <orgName>Lymphopoïèse</orgName>
          <orgName type="acronym">Lymphopoïèse (UMR_1223 / U1223 / U-Pasteur_4)</orgName>
          <date type="start">2011-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Département d'Immunologie, 25-28 rue du docteur Roux, 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://research.pasteur.fr/fr/team/lymphopoiesis/</ref>
          </desc>
          <listRelation>
            <relation name="UMR_1223" active="#struct-300027" type="direct"/>
            <relation name="U-Pasteur_4" active="#struct-300301" type="direct"/>
            <relation name="U1223" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-415981" status="OLD">
          <orgName>Cellule Pasteur</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300301" type="direct"/>
            <relation active="#struct-302037" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-442972" status="VALID">
          <orgName>Mi-mAbs (C/O CIML)</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-182245" type="direct"/>
            <relation name="UM 2" active="#struct-198056" type="indirect"/>
            <relation name="UMR_S 1104" active="#struct-303623" type="indirect"/>
            <relation name="UMR7280" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-414766" status="VALID">
          <orgName>Hôpital Necker - Enfants Malades [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>149 Rue de Sèvres 75015 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://hopital-necker.aphp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-103388" status="VALID">
          <orgName>BD Biosciences</orgName>
          <desc>
            <address>
              <addrLine>BD Biosciences Research Triangle Park North Carolina 27709 USA</addrLine>
              <country key="US"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-324848" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-111290" status="VALID">
          <idno type="ROR">https://ror.org/055wa9133</idno>
          <orgName>Innate Pharma</orgName>
          <desc>
            <address>
              <addrLine>117, Avenue de Luminy - BP 30191 13276 Marseille Cedex 09</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.innate-pharma.com/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-112034" status="VALID">
          <orgName>Academic Medical Center - Academisch Medisch Centrum [Amsterdam]</orgName>
          <orgName type="acronym">AMC</orgName>
          <desc>
            <address>
              <addrLine>Meibergdreef 9 1105 AZ Amsterdam</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.amc.nl/web/home.htm</ref>
          </desc>
          <listRelation>
            <relation active="#struct-120654" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-311714" status="VALID">
          <idno type="ROR">https://ror.org/00f7hpc57</idno>
          <orgName>Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg</orgName>
          <orgName type="acronym">FAU</orgName>
          <desc>
            <address>
              <addrLine>Schlossplatz 4, 91054 Erlangen, Germany</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">http://www.fau.eu/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1043610" status="OLD">
          <orgName>Collège de France - Chaire Médecine expérimentale (A. Fischer)</orgName>
          <date type="start">2014-05-14</date>
          <date type="end">2020-12-31</date>
          <desc>
            <address>
              <addrLine>11 place Marcelin Berthelot F-75231 Paris Cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.college-de-france.fr/site/alain-fischer/index.htm</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300026" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300073" status="VALID">
          <idno type="ROR">https://ror.org/002cp4060</idno>
          <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
          <orgName type="acronym">APHM</orgName>
          <desc>
            <address>
              <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300093" status="VALID">
          <idno type="ISNI">0000 0001 0404 1115 </idno>
          <idno type="ROR">https://ror.org/05jrr4320</idno>
          <orgName>Hôpital de la Timone [CHU - APHM]</orgName>
          <orgName type="acronym">TIMONE</orgName>
          <date type="start">1974-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-timone</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301664" status="OLD">
          <idno type="IdRef">026404788</idno>
          <idno type="ISNI">0000 0001 2188 0914 </idno>
          <idno type="ROR">https://ror.org/0220k9r37</idno>
          <orgName>Université Paris Descartes - Paris 5</orgName>
          <orgName type="acronym">UPD5</orgName>
          <date type="start">1971-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.parisdescartes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300027" status="VALID">
          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <idno type="ROR">https://ror.org/0495fxg12</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <orgName type="acronym">IP</orgName>
          <date type="start">1887-06-04</date>
          <desc>
            <address>
              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300301" status="OLD">
          <idno type="IdRef">027542084</idno>
          <idno type="ISNI">0000000121514068</idno>
          <idno type="ROR">https://ror.org/02n7qrg46</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-302037" status="OLD">
          <orgName>PRES Sorbonne Paris Cité</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-324848" status="INCOMING">
          <orgName>BD Biosciences</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-120654" status="VALID">
          <idno type="IdRef">026431610</idno>
          <idno type="ISNI">0000 0000 8499 2262</idno>
          <idno type="ROR">https://ror.org/04dkp9463</idno>
          <idno type="Wikidata">Q214341</idno>
          <orgName>Universiteit van Amsterdam = University of Amsterdam</orgName>
          <orgName type="acronym">UvA</orgName>
          <date type="start">1632-01-01</date>
          <desc>
            <address>
              <addrLine>Spui 21 1012 WX Amsterdam</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.uva.nl/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300026" status="VALID">
          <orgName>Collège de France</orgName>
          <orgName type="acronym">CdF (institution)</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>