%0 Journal Article %T Plasma Biomarkers Discriminate Clinical Forms of Multiple Sclerosis %+ Department of Immunology %+ Département d'Immunologie - Department of Immunology %+ Centre d'Immunologie Humaine (CIH) %+ Department of neurology %+ STAT-UP Statistical Consulting&Services %+ Center Alicia Koplowitz for Multiple Sclerosis of the Community of Madrid %+ Department of Clinical Immunology %A Tejera-Alhambra, Marta %A Casrouge, Armanda %A de Andrés, Clara %A Seyfferth, Ansgar %A Ramos-Medina, Rocío %A Alonso, Bárbara %A Vega, Janet %A Fernández-Paredes, Lidia %A Albert, Matthew L. %A Sánchez-Ramón, Silvia %Z This study was funded by Fundación Mapfre (http://www.fundacionmapfre.org), Fundación Salud 2000 (http://www.fundacionsalud2000.com), Fondo de Investigación Sanitaria (FIS#12/2759), and the European Research Council Starting Award (http://erc.europa.eu). Marta Tejera-Alhambra received an EFIS grant in 2011 for her stay at Institut Pasteur in Paris. %< avec comité de lecture %@ 1932-6203 %J PLoS ONE %I Public Library of Science %V 10 %N 6 %P e0128952 %8 2015-06-03 %D 2015 %R 10.1371/journal.pone.0128952 %M 26039252 %K Multiple sclerosis %K Chemokines %K Cytokines %K Growth factors %K Inflammation %K Cerebrospinal fluid %K Central nervous system %K Biomarkers %Z Life Sciences [q-bio]/ImmunologyJournal articles %X Multiple sclerosis, the most common cause of neurological disability in young population after trauma, represents a significant public health burden. Current challenges associated with management of multiple sclerosis (MS) patients stem from the lack of biomarkers that might enable stratification of the different clinical forms of MS and thus prompt treatment for those patients with progressive MS, for whom there is currently no therapy available. In the present work we analyzed a set of thirty different plasma cytokines, chemokines and growth factors present in circulation of 129 MS patients with different clinical forms (relapsing remitting, secondary progressive and primary progressive MS) and 53 healthy controls, across two independent cohorts. The set of plasma analytes was quantified with Luminex xMAP technology and their predictive power regarding clinical outcome was evaluated both individually using ROC curves and in combination using logistic regression analysis. Our results from two independent cohorts of MS patients demonstrate that the divergent clinical and histology-based MS forms are associated with distinct profiles of circulating plasma protein biomarkers, with distinct signatures being composed of chemokines and growth/angiogenic factors. With this work, we propose that an evaluation of a set of 4 circulating biomarkers (HGF, Eotaxin/CCL11, EGF and MIP-1β/CCL4) in MS patients might serve as an effective tool in the diagnosis and more personalized therapeutic targeting of MS patients. %G English %2 https://pasteur.hal.science/pasteur-01380997/document %2 https://pasteur.hal.science/pasteur-01380997/file/journal.pone.0128952.PDF %L pasteur-01380997 %U https://pasteur.hal.science/pasteur-01380997 %~ INSERM %~ PASTEUR %~ ATP-IMMUN