%0 Journal Article %T Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy %+ Immunobiologie des Cellules Dendritiques %+ Histopathologie humaine et Modèles animaux %A Barreira da Silva, Rosa %A Laird, Melissa E %A Yatim, Nader %A Fiette, Laurence %A Ingersoll, Molly A %A Albert, Matthew L %Z Funding was provided by the Institut Pasteur (Pasteur-Roux post-doctoral fellowship to R.B.d.S.), the Pasteur Foundation (fellowship to M.E.L.), the Ligue Contre le Cancer (M.L.A.), the Fondation ARC pour la recherche sur le cancer (M.L.A.) and the French government's Invest in the Future Program, managed by the Agence Nationale de la Recherche (LabEx Immuno-Onco (R.B.d.S., M.E.L., N.Y., M.A.I. and M.L.A.)). %< avec comité de lecture %@ 1529-2908 %J Nature Immunology %I Nature Publishing Group %V 16 %N 8 %P 850 - 858 %8 2015-08-01 %D 2015 %R 10.1038/ni.3201 %M 26075911 %K Cancer immunotherapy %K Protein transport %Z Life Sciences [q-bio]/ImmunologyJournal articles %X The success of antitumor immune responses depends on the infiltration of solid tumors by effector T cells, a process guided by chemokines. Here we show that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10 and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide direct in vivo evidence for control of lymphocyte trafficking via CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing biologically active forms of chemokines as a strategy to enhance tumor immunotherapy. %G English %L pasteur-01380810 %U https://pasteur.hal.science/pasteur-01380810 %~ PASTEUR %~ ATP-IMMUN %~ ANR