%0 Journal Article %T Comparative Anatomy of Phagocytic and immunological Synapses %+ Institut Cochin (IC UM3 (UMR 8104 / U1016)) %+ Biologie Cellulaire des Lymphocytes - Lymphocyte Cell Biology %A Niedergang, Florence %A Di Bartolo, Vincenzo %A Alcover, Andrés %Z Work in the laboratory of FN was supported by CNRS, INSERM, and Université Paris Descartes, and grants from Agence Nationale de la Recherche, ANR (2011 BSV3 025 02), Fondation pour la Recherche Médicale (FRM, INE20041102865), and l’Agence Nationale pour la Recherche sur le SIDA et les Hépatites Virales (ANRS). Work in the laboratory of AA and VDB was supported by grants from Institut Pasteur, CNRS, ANR (2011 BSV3 025 02), Fondation ARC pour la Recherche sur le Cancer, La Ligue Contre le Cancer, and ANRS. %< avec comité de lecture %@ 1664-3224 %J Frontiers in Immunology %I Frontiers %8 2016-01-28 %D 2016 %R 10.3389/fimmu.2016.00018 %M 26858721 %K actin %K signal transduction %K immune receptor %K phagocytosis %K immunological synapse %K microtubules %K exocytosis %K endocytosis %Z Life Sciences [q-bio]/Immunology/Adaptive immunology %Z Life Sciences [q-bio]/Cellular Biology %Z Life Sciences [q-bio]/Immunology/Innate immunityJournal articles %X The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types. However, growing experimental evidence shows that a very close series of molecular and cellular events control these two processes. Thus, the tight and dynamic interplay between receptor signaling, actin and microtubule cytoskeleton, and targeted vesicle traffic are all critical features to build functional phagosomes and immunological synapses. Interestingly, both phagocytic cups and immunological synapses display particular spatial and temporal patterns of receptors and signaling molecules, leading to the notion of " phagocytic synapse. " Here, we discuss both types of structures, their organization, and the mechanisms by which they are generated and regulated. %G English %2 https://pasteur.hal.science/pasteur-01286933/document %2 https://pasteur.hal.science/pasteur-01286933/file/fimmu-07-00018.pdf %L pasteur-01286933 %U https://pasteur.hal.science/pasteur-01286933 %~ INSERM %~ PASTEUR %~ UNIV-PARIS5 %~ CNRS %~ USPC %~ UNIV-PARIS %~ UP-SANTE %~ ANR %~ FRM