M. Van-kouwenhove, M. Kedde, and R. Agami, MicroRNA regulation by RNA-binding proteins and its implications for cancer, Nature Reviews Cancer, vol.16, issue.9, pp.644-656, 2011.
DOI : 10.1038/nrc3107

G. Hutvagner and M. Simard, Argonaute proteins: key players in RNA silencing, Nature Reviews Molecular Cell Biology, vol.13, issue.1, pp.22-32, 2008.
DOI : 10.1038/nrm2321

J. Krol, I. Loedige, and W. Filipowicz, The widespread regulation of microRNA biogenesis, function and decay, Nature Reviews Genetics, vol.36, pp.597-610, 2010.
DOI : 10.1038/nrg2843

S. Gu and M. Kay, How do miRNAs mediate translational repression?, Silence, vol.1, issue.1, p.11, 2010.
DOI : 10.1186/1758-907X-1-11

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881910

J. Liu, M. Carmell, F. Rivas, C. Marsden, and J. Thomson, Argonaute2 Is the Catalytic Engine of Mammalian RNAi, Science, vol.305, issue.5689, pp.1437-1441, 2004.
DOI : 10.1126/science.1102513

G. Meister, M. Landthaler, A. Patkaniowska, Y. Dorsett, and G. Teng, Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs, Molecular Cell, vol.15, issue.2, pp.185-197, 2004.
DOI : 10.1016/j.molcel.2004.07.007

T. Rand, K. Ginalski, N. Grishin, and X. Wang, Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity, Proceedings of the National Academy of Sciences, vol.101, issue.40, pp.14385-14389, 2004.
DOI : 10.1073/pnas.0405913101

S. Cheloufi, D. Santos, C. Chong, M. Hannon, and G. , A dicer-independent miRNA biogenesis pathway that requires Ago catalysis, Nature, vol.432, issue.7298, pp.584-589, 2010.
DOI : 10.1038/nature09092

D. Cifuentes, H. Xue, D. Taylor, H. Patnode, and Y. Mishima, A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity, Science, vol.328, issue.5986, pp.1694-1698, 2010.
DOI : 10.1126/science.1190809

S. Diederichs and D. Haber, Dual Role for Argonautes in MicroRNA Processing and Posttranscriptional Regulation of MicroRNA Expression, Cell, vol.131, issue.6, pp.1097-1108, 2007.
DOI : 10.1016/j.cell.2007.10.032

M. Ameyar-zazoua, C. Rachez, M. Souidi, P. Robin, and L. Fritsch, Argonaute proteins couple chromatin silencing to alternative splicing, Nature Structural & Molecular Biology, vol.5, issue.10, pp.998-1004, 2012.
DOI : 10.1016/j.ymeth.2007.10.002

URL : https://hal.archives-ouvertes.fr/pasteur-01393429

M. Benhamed, U. Herbig, T. Ye, A. Dejean, and O. Bischof, Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells, Nature Cell Biology, vol.44, issue.3, pp.266-275, 2012.
DOI : 10.1038/ncb2443

W. Wei, Z. Ba, M. Gao, Y. Wu, and Y. Ma, A Role for Small RNAs in DNA Double-Strand Break Repair, Cell, vol.149, issue.1, pp.101-112, 2012.
DOI : 10.1016/j.cell.2012.03.002

J. Shen, W. Xia, Y. Khotskaya, L. Huo, and K. Nakanishi, EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2, Nature, vol.460, issue.7449, pp.383-387, 2013.
DOI : 10.1038/nature12080

S. Rudel, Y. Wang, R. Lenobel, R. Korner, and H. Hsiao, Phosphorylation of human Argonaute proteins affects small RNA binding, Nucleic Acids Research, vol.39, issue.6, pp.2330-2343, 2010.
DOI : 10.1093/nar/gkq1032

Y. Zeng, H. Sankala, X. Zhang, and P. Graves, Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies, Biochemical Journal, vol.413, issue.3, pp.429-436, 2008.
DOI : 10.1042/BJ20080599

A. Rybak, H. Fuchs, K. Hadian, L. Smirnova, and E. Wulczyn, The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2, Nature Cell Biology, vol.27, issue.12, pp.1411-1420, 2009.
DOI : 10.1038/sj.emboj.7601897

H. Qi, P. Ongusaha, J. Myllyharju, D. Cheng, and O. Pakkanen, Prolyl 4-hydroxylation regulates Argonaute 2 stability, Nature, vol.278, issue.7211, pp.421-424, 2008.
DOI : 10.1038/nature07186

C. Cubenas-potts and M. Matunis, SUMO: A Multifaceted Modifier of Chromatin Structure and Function, Developmental Cell, vol.24, issue.1, pp.1-12, 2013.
DOI : 10.1016/j.devcel.2012.11.020

J. Ouyang, A. Valin, and G. Gill, Regulation of Transcription Factor Activity by SUMO Modification, Methods Mol Biol, vol.497, pp.141-152, 2009.
DOI : 10.1007/978-1-59745-566-4_9

H. Ulrich, Ubiquitin and SUMO in DNA repair at a glance, Journal of Cell Science, vol.125, issue.2, pp.249-254, 2012.
DOI : 10.1242/jcs.091801

H. Neyret-kahn, M. Benhamed, T. Ye, L. Gras, S. Cossec et al., Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation, Genome Research, vol.23, issue.10, pp.1563-1579, 2013.
DOI : 10.1101/gr.154872.113

G. Praefcke, K. Hofmann, and R. Dohmen, SUMO playing tag with ubiquitin, Trends in Biochemical Sciences, vol.37, issue.1, pp.23-31, 2012.
DOI : 10.1016/j.tibs.2011.09.002

N. Martin, K. Schwamborn, V. Schreiber, A. Werner, and C. Guillier, PARP-1 transcriptional activity is regulated by sumoylation upon heat shock, The EMBO Journal, vol.18, issue.22, pp.3534-3548, 2009.
DOI : 10.1016/j.molcel.2008.01.013

O. Kirsh, J. Seeler, A. Pichler, A. Gast, and S. Muller, The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase, The EMBO Journal, vol.21, issue.11, pp.2682-2691, 2002.
DOI : 10.1093/emboj/21.11.2682

A. Pichler, A. Gast, J. Seeler, A. Dejean, and F. Melchior, The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity, Cell, vol.108, issue.1, pp.109-120, 2002.
DOI : 10.1016/S0092-8674(01)00633-X

J. Gareau and C. Lima, The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition, Nature Reviews Molecular Cell Biology, vol.8, issue.12, pp.861-871, 2010.
DOI : 10.1038/nrm3011

J. Desterro, M. Rodriguez, and R. Hay, SUMO-1 Modification of I??B?? Inhibits NF-??B Activation, Molecular Cell, vol.2, issue.2, pp.233-239, 1998.
DOI : 10.1016/S1097-2765(00)80133-1

J. Steffan, N. Agrawal, J. Pallos, E. Rockabrand, and L. Trotman, SUMO Modification of Huntingtin and Huntington's Disease Pathology, Science, vol.304, issue.5667, pp.100-104, 2004.
DOI : 10.1126/science.1092194

M. Demarque, K. Nacerddine, H. Neyret-kahn, A. Andrieux, and E. Danenberg, Sumoylation by Ubc9 Regulates the Stem Cell Compartment and Structure and Function of the Intestinal Epithelium in Mice, Gastroenterology, vol.140, issue.1, pp.286-296, 2011.
DOI : 10.1053/j.gastro.2010.10.002

URL : https://hal.archives-ouvertes.fr/pasteur-00572277

I. Heo and V. Kim, Regulating the Regulators: Posttranslational Modifications of RNA Silencing Factors, Cell, vol.139, issue.1, pp.28-31, 2009.
DOI : 10.1016/j.cell.2009.09.013

Y. Kim, I. Heo, and V. Kim, Modifications of Small RNAs and Their Associated Proteins, Cell, vol.143, issue.5, pp.703-709, 2010.
DOI : 10.1016/j.cell.2010.11.018

V. Lallemand-breitenbach, J. M. Benhenda, S. Nasr, R. Lei, and M. , Arsenic degrades PML or PML???RAR?? through a SUMO-triggered RNF4/ubiquitin-mediated pathway, Nature Cell Biology, vol.112, issue.5, pp.547-555, 2008.
DOI : 10.1038/nmeth891

M. Tatham, M. Geoffroy, L. Shen, A. Plechanovova, and N. Hattersley, RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation, Nature Cell Biology, vol.112, issue.5, pp.538-546, 2008.
DOI : 10.1042/BJ20052030

Y. Erker, H. Neyret-kahn, J. Seeler, A. Dejean, and A. Atfi, Arkadia, a Novel SUMO-Targeted Ubiquitin Ligase Involved in PML Degradation, Molecular and Cellular Biology, vol.33, issue.11, pp.2163-2177, 2013.
DOI : 10.1128/MCB.01019-12

C. Maison, D. Bailly, D. Roche, R. Montes-de-oca, and A. Probst, SUMOylation promotes de novo targeting of HP1?? to pericentric heterochromatin, Nature Genetics, vol.7, issue.3, pp.220-227, 2011.
DOI : 10.1002/pmic.200600784

URL : https://hal.archives-ouvertes.fr/hal-00685744

Y. Mo and S. Moschos, Targeting Ubc9 for cancer therapy, Expert Opinion on Therapeutic Targets, vol.352, issue.24, pp.1203-1216, 2005.
DOI : 10.1126/science.1068999

D. Voller, J. Reinders, G. Meister, and A. Bosserhoff, Strong reduction of AGO2 expression in melanoma and cellular consequences, British Journal of Cancer, vol.46, issue.12, 2013.
DOI : 10.1016/j.biocel.2012.08.005

Y. Deribe, T. Pawson, and I. Dikic, Post-translational modifications in signal integration, Nature Structural & Molecular Biology, vol.161, issue.6, pp.666-672, 2010.
DOI : 10.1038/nsmb.1842