Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe - Institut Pasteur Access content directly
Journal Articles Nature Genetics Year : 2012

Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe

Abstract

Shigella are human-adapted Escherichia coli that have gained the ability to invade the human gut mucosa and cause dysentery(1,2), spreading efficiently via low-dose fecal-oral transmission(3,4). Historically, S. sonnei has been predominantly responsible for dysentery in developed countries but is now emerging as a problem in the developing world, seeming to replace the more diverse Shigella flexneri in areas undergoing economic development and improvements in water quality(4-6). Classical approaches have shown that S. sonnei is genetically conserved and clonal(7). We report here whole-genome sequencing of 132 globally distributed isolates. Our phylogenetic analysis shows that the current S. sonnei population descends from a common ancestor that existed less than 500 years ago and that diversified into several distinct lineages with unique characteristics. Our analysis suggests that the majority of this diversification occurred in Europe and was followed by more recent establishment of local pathogen populations on other continents, predominantly due to the pandemic spread of a single, rapidly evolving, multidrug-resistant lineage.

Dates and versions

pasteur-01117702 , version 1 (17-02-2015)

Identifiers

Cite

Kathryn E. Holt, Stephen Baker, François-Xavier Weill, Edward C Holmes, Andrew Kitchen, et al.. Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe. Nature Genetics, 2012, 44 (9), pp.1056-9. ⟨10.1038/ng.2369⟩. ⟨pasteur-01117702⟩

Collections

PASTEUR
51 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More