%0 Journal Article %T The global establishment of a highly-fluoroquinolone resistant Salmonella enterica serotype Kentucky ST198 strain %+ Centre National de Référence - National Reference Center Escherichia coli, Shigella et Salmonella (CNR-ESS) %+ Laboratoire de sécurité des aliments de Maisons-Alfort (LSAl) %+ Chittagong Veterinary and Animal Sciences University (CVASU) %+ Bundesinstitut für Risikobewertung - Federal Institute for Risk Assessment (BfR) %+ Institut Pasteur du Maroc %+ University of Ibadan %+ Bio Chêne Vert %+ Danmarks Tekniske Universitet = Technical University of Denmark (DTU) %+ University of Copenhagen = Københavns Universitet (UCPH) %+ Infectiologie et Santé Publique (UMR ISP) %A Le Hello, Simon %A Bekhit, Amany %A Granier, Sophie A %A Barua, Himel %A Beutlich, Janine %A Zaj, Magdalena %A Münch, Sebastian %A Sintchenko, Vitali %A Bouchrif, Brahim %A Fashae, Kayode %A Pinsard, Jean-Louis %A Sontag, Lucile %A Fabre, Laetitia %A Garnier, Martine %A Guibert, Véronique %A Howard, Peter %A Hendriksen, Rene S %A Christensen, Jens Peter %A Biswas, Paritosh %A Cloeckaert, Axel %A Rabsch, Wolfgang %A Wasyl, Dariusz %A Doublet, Benoit %A Weill, François-Xavier %Z French Government “Investissementd’Avenir” program (grantnumber ANR-10-LABX-62-IBEID). %< avec comité de lecture %@ 1664-302X %J Frontiers in Microbiology %I Frontiers Media %V 4 %N 395 %P 1-10 %8 2013-12-18 %D 2013 %R 10.3389/fmicb.2013.00395 %M 24385975 %K poultry %K QRDR %K MDR Salmonella dissemination %K SGI1 %K S Kentucky %K ST198 %Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles %X While the spread of Salmonella enterica serotype Kentucky resistant to ciprofloxacin across Africa and the Middle-East has been described recently, the presence of this strain in humans, food, various animal species (livestock, pets, and wildlife) and in environment is suspected in other countries of different continents. Here, we report results of an in-depth molecular epidemiological study on a global human and non-human collection of S. Kentucky (n = 70). We performed XbaI-pulsed field gel electrophoresis and multilocus sequence typing, assessed mutations in the quinolone resistance-determining regions, detected β-lactam resistance mechanisms, and screened the presence of the Salmonella genomic island 1 (SGI1). In this study, we highlight the rapid and extensive worldwide dissemination of the ciprofloxacin-resistant S. Kentucky ST198-X1-SGI1 strain since the mid-2000s in an increasingly large number of contaminated sources, including the environment. This strain has accumulated an increasing number of chromosomal and plasmid resistance determinants and has been identified in the Indian subcontinent, Southeast Asia and Europe since 2010. The second substitution at position 87 in GyrA (replacing the amino acid Asp) appeared helpful for epidemiological studies to track the origin of contamination. This global study provides evidence leading to the conclusion that high-level resistance to ciprofloxacin in S. Kentucky is a simple microbiological trait that facilitates the identification of the epidemic clone of interest, ST198-X1-SGI1. Taking this into account is essential in order to detect and monitor it easily and to take rapid measures in livestock to ensure control of this infection. %G English %2 https://pasteur.hal.science/pasteur-01115946/document %2 https://pasteur.hal.science/pasteur-01115946/file/The%20global%20establishment.pdf %L pasteur-01115946 %U https://pasteur.hal.science/pasteur-01115946 %~ PASTEUR %~ ANSES %~ RIIP %~ UNIV-TOURS %~ INRA %~ SANTE_PUB_INSERM %~ RIIP_PARIS %~ RIIP_MAROC %~ AGREENIUM %~ INRAE %~ ANR %~ INFECTIOLOGIE-SANTE-PUBLIQUE