%0 Journal Article %T T(H)1 cells control themselves by producing interleukin-10. %+ Division of Immunoregulation %+ Développement des Lymphocytes %A O'Garra, Anne %A Vieira, Paulo %< avec comité de lecture %@ 1474-1741 %J Nature Reviews Immunology %I Nature Publishing Group %V 7 %N 6 %P 425-8 %8 2007-06 %D 2007 %R 10.1038/nri2097 %M 17525751 %Z Life Sciences [q-bio]/ImmunologyJournal articles %X Inflammatory T helper 1 (T(H)1)-cell responses successfully eradicate pathogens, but often also cause immunopathology. To minimize this deleterious side-effect the anti-inflammatory cytokine interleukin-10 (IL-10) is produced. Although IL-10 was originally isolated from T(H)2 cells it is now known to be produced by many cell types. Here, we discuss the recent evidence that shows that T(H)1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection. %G English %L pasteur-00362024 %U https://pasteur.hal.science/pasteur-00362024 %~ PASTEUR %~ RIIP_PARIS