%0 Journal Article %T Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation. %+ Biologie des Régulations Immunitaires %+ Biologie des Populations Lymphocytaires %+ Génétique Moléculaire des Virus Respiratoires %A Schlecht, Géraldine %A Garcia, Sylvie %A Escriou, Nicolas %A Freitas, Antonio A %A Leclerc, Claude %A Dadaglio, Gilles %< avec comité de lecture %@ 0006-4971 %J Blood %I American Society of Hematology %V 104 %N 6 %P 1808-15 %8 2004-09-15 %D 2004 %R 10.1182/blood-2004-02-0426 %M 15166034 %Z Life Sciences [q-bio]/ImmunologyJournal articles %X Like their human counterparts, mouse plasmacytoid dendritic cells (pDCs) play a central role in innate immunity against viral infections, but their capacity to prime T cells in vivo remains unknown. We show here that virus-activated pDCs differentiate into antigen-presenting cells able to induce effector/memory CD8(+) T-cell responses in vivo against both epitopic peptides and endogenous antigen, whereas pDCs activated by synthetic oligodeoxynucleotides containing unmethylated cytosine-guanine motifs (CpG) acquire only the ability to recall antigen-experienced T-cell responses. We also show that immature pDCs are unable to induce effector or regulatory CD8(+) T-cell responses. Thus, murine pDCs take part in both innate and adaptive immune responses by directly priming naive CD8(+) T cells during viral infection. %G English %L pasteur-00327333 %U https://pasteur.hal.science/pasteur-00327333 %~ PASTEUR %~ UNIV-PARIS7 %~ CNRS %~ RIIP_PARIS %~ ATP-IMMUN %~ UNIV-PARIS