%0 Journal Article %T 2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread. %+ Virus Lents %+ Chimie Organique %+ Centre de Physiopathologie Toulouse Purpan (CPTP) %A Bajramovic, Jeffrey J %A Volmer, Romain %A Syan, Sylvie %A Pochet, Sylvie %A Gonzalez-Dunia, Daniel %< avec comité de lecture %@ 0066-4804 %J Antimicrobial Agents and Chemotherapy %I American Society for Microbiology %V 48 %N 4 %P 1422-5 %8 2004 %D 2004 %R 10.1128/AAC.48.4.1422-1425.2004 %M 15047559 %Z Life Sciences [q-bio]/Other [q-bio.OT]Journal articles %X Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV. %G English %L pasteur-00166243 %U https://pasteur.hal.science/pasteur-00166243 %~ PASTEUR %~ UNIV-TLSE3 %~ CNRS %~ RIIP_PARIS %~ GIP-BE %~ INFINITY %~ UNIV-UT3 %~ UT3-INP %~ UT3-TOULOUSEINP