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Journal Articles Nature Communications Year : 2019

Associations of autozygosity with a broad range of human phenotypes

David J. Clark (1) , Yukinori Okada (2, 3, 4) , Kristjan Moore (5) , Dan Mason (6) , Nicola Pirastu (1) , Ilaria Gandin (7, 8) , Hannele Mattsson , Catriona Barnes (1) , Kuang Lin , Jing Hua Zhao (9) , Patrick Deelen , Rebecca Rohde , Claudia Schurmann (10) , Xiuqing Guo (11) , Franco Giulianini (12) , Weihua Zhang (13) , Carolina Medina-Gomez , Robert Karlsson (14) , Yanchun Bao , Traci Bartz , Clemens Baumbach , Ginevra Biino (15) , Matthew Bixley , Marco Brumat (8) , Jin-Fang Chai , Tanguy Corre (16) , Diana Cousminer (17) , Annelot Dekker , David W Eccles (18) , Kristel van Eijk (19) , Christian Fuchsberger (20) , He Gao , Marine Germain (21) , Scott Gordon (22) , Hugoline de Haan (23) , Sarah Harris , Edith Hofer (24) , Alicia Huerta-Chagoya , Catherine Igartua , Iris Jansen (25) , Yucheng Jia , Tim Kacprowski , Torgny Karlsson , Marcus Kleber (26) , Shengchao Alfred Li (27) , Ruifang Li-Gao , Anubha Mahajan (28) , Koichi Matsuda , Karina Meidtner (29) , Weihua Meng , May Montasser , Peter van Der Most (30) , Matthias Munz , Teresa Nutile (31) , Teemu Palviainen , Gauri Prasad , Rashmi Prasad , Tallapragada Divya Sri Priyanka , Federica Rizzi , Erika Salvi (32) , Bishwa Sapkota , Daniel Shriner , Line Skotte , Melissa Smart , Albert Vernon Smith (33) , Ashley van Der Spek (34) , Cassandra Spracklen , Rona J Strawbridge (35) , Salman Tajuddin , Stella Trompet (36) , Constance Turman , Niek Verweij (37) , Clara Viberti , Lihua Wang , Helen Warren (38) , Robyn Wootton , Lisa Yanek (39) , Jie Yao , Noha Yousri , Wei Zhao (40) , Adebowale Adeyemo , Saima Afaq , Carlos Alberto Aguilar-Salinas , Masato Akiyama (4) , Matthew Albert (41, 42, 43) , Matthew Allison , Maris Alver (44) , Tin P. Aung (45) , Fereidoun Azizi , Amy Bentley , Heiner Boeing (46) , Eric Boerwinkle (47) , Judith Borja (48) , Gert de Borst , Erwin Bottinger (49) , Linda Broer (50) , Harry Campbell (1) , Stephen Chanock (51) , Miao-Li Chee , Guanjie Chen , Yii-Der Chen , Zhengming Chen (52) , Yen-Feng Chiu , Massimiliano Cocca , Francis Collins , Maria Pina Concas , Janie Corley , Giovanni Cugliari , Rob van Dam , Anna Damulina , Maryam Daneshpour , Felix Day , Graciela Delgado (53) , Klodian Dhana , Alexander Doney (54) , Marcus Dörr (55) , Ayo Doumatey , Nduna Dzimiri , S Sunna Ebenesersdóttir (5) , Joshua Elliott (56) , Paul I Elliott (57) , Ralf Ewert , Janine Felix , Krista Fischer (58) , Barry I Freedman (59) , Giorgia Girotto (8, 8) , Anuj Goel (60) , Martin Gögele , Mark Goodarzi , Mariaelisa Graff , Einat Granot-Hershkovitz , Francine Grodstein (61) , Simonetta Guarrera , Daniel Gudbjartsson (5) , Kamran Guity , Bjarni Gunnarsson (5) , Yu Guo (62) , Saskia Hagenaars (63) , Christopher Haiman (64) , Avner Halevy , Tamara B. Harris (65) , Mehdi Hedayati , David van Heel , Makoto Hirata , Imo Höfer , Chao Agnes Hsiung , Jinyan Huang , Yi-Jen Hung , M Arfan Ikram (66) , Anuradha Jagadeesan (5) , Pekka Jousilahti , Yoichiro Kamatani (67, 4) , Masahiro Kanai (68, 4) , Nicola Kerrison , Thorsten Kessler (5) , Kay-Tee Khaw (69) , Chiea Chuen Khor (70) , Dominique de Kleijn (71) , Woon-Puay Koh (45) , Ivana Kolcic (72) , Peter Kraft (73) , Bernhard Krämer , Zoltan Kutalik (74) , Johanna Kuusisto (75) , Claudia Langenberg (76) , Lenore Launer (65) , Deborah Lawlor , I-Te Lee , Wen-Jane Lee , Markus Lerch , Liming Li (77) , Jianjun Liu (78) , Marie Loh , Stephanie London (79) , Stephanie Loomis , Yingchang Lu (80) , Jian’an Luan (81) , Reedik Mägi , Ani Manichaikul , Paolo Manunta , Gísli Másson (5) , Nana Matoba (4) , Xue Mei (82) , Christa Meisinger , Thomas Meitinger (83) , Massimo Mezzavilla , Lili Milani (44) , Iona Millwood , Yukihide Momozawa , Amy Moore (84) , Pierre-Emmanuel Morange (85, 86) , Hortensia Moreno-Macías , Trevor Mori , Alanna Morrison , Taulant Muka , Yoshinori Murakami , Alison Murray (87) , Renée de Mutsert (88) , Josyf Mychaleckyj , Mike Nalls (89) , Matthias Nauck (90) , Matt Neville , Ilja Nolte (91) , Ken K. Ong (92) , Lorena Orozco , Sandosh Padmanabhan (93) , Gunnar Pálsson (5) , James Pankow , Cristian Pattaro , Alison Pattie , Ozren Polasek (94) , Neil Poulter (95) , Peter Pramstaller (94) , Lluis Quintana-Murci (96, 97) , Katri Räikkönen (17) , Sarju Ralhan , Dabeeru Rao , Wouter van Rheenen (19) , Stephen Rich , Paul Ridker (98) , Cornelius Rietveld (99) , Antonietta Robino , Frank van Rooij , Daniela Ruggiero (31) , Yasaman Saba , Charumathi Sabanayagam , Maria Sabater-Lleal , Cinzia Felicita Sala , Veikko Salomaa (100) , Kevin Sandow , Helena Schmidt (24) , Laura J. Scott (101) , William Scott , Bahareh Sedaghati-Khayat , Bengt Sennblad (102) , Jessica van Setten (103) , Peter Sever (95) , Wayne H-H Sheu , Yuan Shi (64) , Smeeta Shrestha , Sharvari Rahul Shukla , Jon Sigurdsson (5) , Timo Tonis Sikka , Jai Rup Singh , Blair Smith , Alena Stančáková (75) , Alice Stanton , John M Starr (1) , Lilja Stefansdottir (104, 5) , Leon Straker , Patrick Sulem (50, 5) , Gardar Sveinbjornsson (5) , Morris Swertz (105) , Adele Taylor , Kent D Taylor (106) , Natalie Terzikhan , Yih-Chung Tham , Gudmar Thorleifsson (5) , Unnur Thorsteinsdóttir (5) , Annika Tillander , Russell Tracy , Teresa Tusié-Luna (107) , Ioanna Tzoulaki (95) , Simona Vaccargiu , Jagadish Vangipurapu , Jan Veldink (19) , Veronique Vitart (108) , Uwe U. Völker (109) , Eero Vuoksimaa , Salma Wakil , Melanie Waldenberger (110) , Gurpreet Wander , Ya Xing Wang , Nicholas J. Wareham (76) , Sarah Wild , Chittaranjan Yajnik (111) , Jian-Min Yuan (112) , Lingyao Zeng , Liang Zhang (113) , Jie Zhou (114) , Najaf Amin (115) , Folkert Asselbergs (116) , Stephan Bakker , Diane Becker , Benjamin Lehne , David Bennett (117) , Leonard van den Berg (19) , Sonja I Berndt (118) , Dwaipayan Bharadwaj , Lawrence Bielak , Murielle Bochud (119) , Mike Boehnke , Claude Bouchard (120) , Jonathan Bradfield , Jennifer Brody (121) , Archie Campbell (1) , Shai Carmi , Mark Caulfield , David Cesarini , John Chambers (122) , Giriraj Ratan Chandak , Ching-Yu Cheng (123) , Marina Ciullo (31) , Marilyn Cornelis , Daniele Cusi (32) , George Davey Smith (124) , Ian Deary (87) , Rajkumar Dorajoo (125) , Cornelia M. van Duijn (126) , David Ellinghaus (127) , Jeanette Erdmann (128) , Johan Eriksson (17) , Evangelos Evangelou (129) , Michele Evans , Jessica Faul (130) , Bjarke Feenstra , Mary F. Feitosa (131) , Sylvain Foisy , Andre Franke (132) , Yechiel Friedlander , Paolo Gasparini (133, 8) , Christian Gieger (83) , Clicerio Gonzalez , Philippe Goyette , Struan Grant , Lyn Griffiths , Leif C. Groop (134) , Vilmundur Gudnason (135) , Ulf Gyllensten (94) , Hakon Hakonarson (136) , Anders Hamsten (137) , Pim van Der Harst (91) , Chew-Kiat Heng , Andrew Hicks (138) , Hagit Hochner , Heikki Huikuri (139) , Steven Hunt (140) , Vincent Jaddoe (141) , Philip L de Jager (142) , Magnus Johannesson , Åsa Johansson (94) , Jost Jonas (143) , J Wouter Jukema (144) , Juhani Junttila , Jaakko Kaprio (145) , Sharon Kardia (146) , Fredrik Karpe (52) , Meena Kumari (147) , Markku Laakso (148) , Sander van Der Laan , Jari Lahti (149) , Matthias Laudes , Rodney Lea , Wolfgang Lieb (150) , Thomas Lumley (151) , Nicholas M Martin (152) , Winfried März (153) , Giuseppe Matullo (154) , Mark I. Mccarthy (155) , Sarah M Medland (156) , Tony Merriman , Andres Metspalu (44) , Brian Meyer , Karen L. Mohlke (157) , Grant W. Montgomery (115) , Dennis Mook-Kanamori , Patricia Munroe , Kari E. North (158) , Dale R. Nyholt (17) , Jeffery O’connell , Carole C. Ober (159) , Albertine Oldehinkel , Walter Palmas , Colin Palmer (54) , Gerard Pasterkamp (160) , Etienne Patin (96, 97) , Craig Pennell , Louis Pérusse (161) , Patricia Peyser , Mario Pirastu (162) , Tinca Polderman , David Porteous (1) , Danielle Posthuma (163) , Bruce Psaty (121) , John Rioux , Fernando Rivadeneira (164) , Charles N Rotimi (165) , Jerome Rotter (166) , Igor Rudan (94, 1) , Hester den Ruijter , Dharambir Sanghera , Naveed Sattar (167) , Reinhold Schmidt (87) , Matthias B Schulze (168) , Heribert Schunkert (128) , Robert A. Scott (169) , Alan Shuldiner (170) , Xueling Sim (171) , Neil Small , Jennifer Smith , Nona Sotoodehnia , E-Shyong Tai , Alexander Teumer (50) , Nicholas J. Timpson (172) , Daniela Toniolo (173) , David-Alexandre Trégouët (174, 175) , Tiinamaija Tuomi , Peter Vollenweider (176) , Carol Wang , David Weir (177) , John Whitfield (156) , Cisca Wijmenga (178) , Tien-Yin Wong (179) , John W. Wright (6) , Jingyun Yang (87) , Lei Yu (180) , Babette Zemel , Alan Zonderman , Markus Perola (181) , Patrik K. E. Magnusson (182) , André Uitterlinden (50) , Jaspal Kooner , Daniel Chasman (98) , Ruth J. F. Loos (169) , Nora Franceschini (158) , Lude Franke (91) , Chris Haley , Caroline Hayward (94) , Robin G. Walters (183) , John Perry (184) , Tōnu Esko , Agnar Helgason (5) , Kari Stefansson (5) , Peter Joshi (1) , Michiaki Kubo , James Wilson (185, 1)
1 University of Edinburgh
2 BROAD INSTITUTE - Broad Institute of MIT and Harvard
3 Osaka University Graduate School of Medicine
4 RIKEN IMS - Laboratory for Cardiovascular Genomics and Informatics [Yokohama]
5 deCODE genetics [Reykjavik]
6 BIHR - Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
7 Area Science Park
8 Università degli studi di Trieste = University of Trieste
9 MRC Epidemiology Unit, Institute of Metabolic Science
10 Interfaculty Institute for Genetics and Functional Genomics
11 Harbor UCLA Medical Center [Torrance, Ca.]
12 Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA
13 ECE - Department of Electrical and Computer Engineering [Waterloo]
14 MEB - Department of Medical Epidemiology and Biostatistics
15 Institute of Pop. Genetics, CNR, Sassari;Shardna life science Pula Cagliari
16 SIB - Swiss Institute of Bioinformatics [Lausanne]
17 Medstar Research Institute
18 FSU - Florida State University [Tallahassee]
19 University Medical Center [Utrecht]
20 Centre for Population Health Sciences
21 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
22 California State University [Sacramento]
23 Department of Thrombosis and Haemostasis
24 Medical University Graz
25 Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam
26 Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg
27 FNLCR - Frederick National Laboratory for Cancer Research
28 Wellcome Trust Centre of Human Genetics, University of Oxford
29 Department of Epidemiology
30 UMCG - University Medical Center Groningen [Groningen]
31 Institute of Genetics and Biophysics
32 Department of Medicine, Surgery, and Dentistry
33 Icelandic Heart Association, Kopavogur, Iceland.
34 Department of Epidemiology [Rotterdam]
35 University of Glasgow
36 Department of Cardiology, Leiden University Medical Center, Leiden
37 Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA,
38 QMUL - Queen Mary University of London
39 General Internal Medicine, Johns Hopkins School of Medicine
40 IBMP - Institut de biologie moléculaire des plantes
41 Immunobiologie des Cellules dendritiques
42 CRT - Centre de Recherche Translationnelle - Center for Translational Science
43 Genentech, Inc.
44 University of Tartu
45 Duke-NUS Medical School [Singapore]
46 DifE - Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
47 Human Genome Sequencing Center, Baylor College of Medicine
48 University of San Carlos
49 MSSM - Icahn School of Medicine at Mount Sinai [New York]
50 King‘s College London
51 Division of Cancer Epidemiology and Genetics
52 University of Oxford
53 Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg
54 Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee
55 Department of Internal Medicine B, University Medicine Greifswald, Greifswald
56 University of Chicago
57 University of Huddersfield
58 Infectious diseases division, Department of internal medicine
59 Department of Internal Medicine - Section on Nephrology [Winston-Salem, NC, USA]
60 Radcliffe Department of Medicine [Oxford]
61 Department of Epidemiology
62 KMUST - Kunming University of Science and Technology
63 Sans affiliation
64 USC - University of Southern California
65 NIA - National Institute on Aging [Bethesda, USA]
66 Erasmus MC - Erasmus University Medical Center [Rotterdam]
67 CNG - Centre National de Génotypage
68 Osaka University Graduate School of Medicine
69 MRC Centrer for Nutritional Epidemiology and Cancer Prevention and Survival
70 NUS - National University of Singapore
71 ECL - Experimental Cardiology Laboratory
72 Department of Medical Statistics, Epidemiology and Medical Informatics
73 Department of Epidemiology
74 Department of Medical Genetics
75 Department of Medicine
76 MRC Epidemiology Unit
77 Capital Normal University [Beijing]
78 Saw Swee Hock School of Public Health
79 National Institute for Environmental Health Sciences Research Triangle Park
80 Brown University
81 MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge
82 Toyota Research Institute
83 Helmholtz Zentrum München = German Research Center for Environmental Health
84 Department of Chemistry and Biochemistry [Boulder]
85 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
86 TIMONE - Hôpital de la Timone [CHU - APHM]
87 Metacohorts Consortium
88 LUMC - Leiden University Medical Center
89 NIH - National Institutes of Health [Bethesda]
90 Institute of Clinical Chemistry and Laboratory Medicine
91 University of Groningen [Groningen]
92 Medical Research Concil Epidemiology Unit
93 Faculty of Medicine
94 Genetics and Pathology
95 Imperial College London
96 Génétique Evolutive Humaine - Human Evolutionary Genetics
97 C3BI - Centre de Bioinformatique, Biostatistique et Biologie Intégrative
98 Brigham and Women's Hospital [Boston]
99 Erasmus University Rotterdam
100 Department of Chronic Disease Prevention
101 Department of Biostatistics and Center for Statistical Genetics
102 SBC - Stockholm Bioinformatics Center
103 Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht
104 INRH
105 Department of Genetics
106 LA BioMed - Los Angeles Biomedical Research Institute
107 Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico]
108 Western General Hospital
109 Interfaculty Institute for Genetics and Functional Genomics
110 German Research Center for Environmental Health - Helmholtz Center München (GmbH)
111 Medical Research Council
112 Division of Cancer Control and Population Sciences
113 Zhengzhou University of Light Industry
114 Department of Electrical and Electronic Engineering [Niigata Univ.]
115 Genetic Epidemiology Unit
116 UCL - University College of London [London]
117 Aston Business School
118 Division of Cancer Epidemiology and Genetics [Bethesda, MD, États-Unis]
119 CHUV - Centre Hospitalier Universitaire Vaudois
120 Pennington Biomedical Research Center
121 University of Washington [Seattle]
122 Guy's and St Thomas' Hospitals
123 NPU - Northwestern Polytechnical University [Xi'an]
124 Department of Social Medicine
125 Department of Genomics of Common Disease [London, UK]
126 Department of Internal Medicine
127 Institute of Clinical Molecular Biology
128 Medizinische Klinik II
129 Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology
130 Institute for Social Research
131 Division of Statistical Genomics
132 Institute for Clinical Molecular Biology
133 Department of Physics
134 Skane University Hospital [Lund]
135 Icelandic Heart Association
136 The Center for Applied Genomics
137 Karolinska Institutet [Stockholm]
138 LGMNPN - Génétique moléculaire de la neurotransmission et des processus neurodégénératifs
139 Medical Research Center Oulu
140 University of Utah School of Medicine [Salt Lake City]
141 The Generation R Study; Pediatrics; Epidemiology
142 CTCN - Center for Translational and Computational Neuroimmunology [New York, NY, États-Unis]
143 Universität Heidelberg [Heidelberg] = Heidelberg University
144 Interuniversity Cardiology Institute Netherlands
145 National Institute for Health and Welfare [Helsinki]
146 School of Public Health
147 Department of Epidemiology and Public Health
148 Department of Medicine
149 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
150 Institute of Epidemiology and Biobank PopGen
151 Department of Biostatistics, University of Washington
152 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
153 Clinical Institute of Medical and Chemical Laboratory Diagnostics
154 Department of Genetics, Biology and Biochemistry
155 OCDEM - Oxford Centre for Diabetes, Endocrinology and Metabolism
156 QIMR Berghofer Medical Research Institute
157 Department of Genetics
158 Department of Epidemiology
159 UIC - University of Illinois [Chicago]
160 Experimental Cardiology Laboratory
161 Genetic Epidemiology and Clinical Research Group
162 CNR - National Research Council of Italy | Consiglio Nazionale delle Ricerche
163 Functional Genomics
164 Department of Epidemiology
165 NHGRI - National Human Genome Research Institute
166 School of Medicine [Los Angeles]
167 Department of Pathological Biochemistry
168 DIfE - German Institute of Human Nutrition Potsdam-Rehbrücke
169 Institute of Metabolic Science
170 University of Maryland School of Medicine [Baltimore, MD, USA]
171 Centre for Molecular Epidemiology
172 Centre for Causal Analyses in Translational Epidemiology
173 IRCCS San Raffaele Scientific Institute [Milan, Italie]
174 U937
175 BPH - Bordeaux population health
176 Department of Internal Medicine
177 University of Michigan [Ann Arbor]
178 Department of Medical Genetics
179 Singapore Eye Research Institute
180 IETR - Institut d'Électronique et des Technologies du numéRique
181 FIMM - Institute for Molecular Medicine Finland [Helsinki]
182 Department of Psychiatry and Psychotherapy
183 Department of Genomics of Common Disease
184 Department of Microbiology, The Freeman Hospital
185 Department Biostatistics University of North Carolina
Nicola Pirastu
  • Function : Author
  • PersonId : 910143
Hannele Mattsson
  • Function : Author
Kuang Lin
  • Function : Author
Patrick Deelen
  • Function : Author
Rebecca Rohde
  • Function : Author
Carolina Medina-Gomez
  • Function : Author
Yanchun Bao
  • Function : Author
Traci Bartz
  • Function : Author
Clemens Baumbach
  • Function : Author
Matthew Bixley
  • Function : Author
Jin-Fang Chai
  • Function : Author
Annelot Dekker
  • Function : Author
He Gao
  • Function : Author
Sarah Harris
Alicia Huerta-Chagoya
  • Function : Author
Catherine Igartua
  • Function : Author
Yucheng Jia
  • Function : Author
Tim Kacprowski
  • Function : Author
Torgny Karlsson
  • Function : Author
Ruifang Li-Gao
  • Function : Author
Koichi Matsuda
  • Function : Author
Weihua Meng
  • Function : Author
May Montasser
  • Function : Author
Matthias Munz
  • Function : Author
Teresa Nutile
  • Function : Author
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Teemu Palviainen
  • Function : Author
Gauri Prasad
  • Function : Author
Rashmi Prasad
  • Function : Author
Federica Rizzi
  • Function : Author
Bishwa Sapkota
  • Function : Author
Daniel Shriner
  • Function : Author
Line Skotte
  • Function : Author
Melissa Smart
  • Function : Author
Cassandra Spracklen
  • Function : Author
Rona J Strawbridge
  • Function : Author
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Salman Tajuddin
  • Function : Author
Constance Turman
  • Function : Author
Clara Viberti
  • Function : Author
Lihua Wang
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Robyn Wootton
  • Function : Author
Jie Yao
  • Function : Author
Noha Yousri
  • Function : Author
Adebowale Adeyemo
  • Function : Author
Saima Afaq
  • Function : Author
Carlos Alberto Aguilar-Salinas
  • Function : Author
Matthew Allison
  • Function : Author
Maris Alver
  • Function : Author
Fereidoun Azizi
  • Function : Author
Amy Bentley
  • Function : Author
Judith Borja
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Gert de Borst
  • Function : Author
Harry Campbell
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Miao-Li Chee
  • Function : Author
Guanjie Chen
  • Function : Author
Yii-Der Chen
  • Function : Author
Yen-Feng Chiu
  • Function : Author
Massimiliano Cocca
  • Function : Author
Francis Collins
  • Function : Author
Maria Pina Concas
  • Function : Author
Janie Corley
  • Function : Author
Giovanni Cugliari
  • Function : Author
Rob van Dam
  • Function : Author
Anna Damulina
  • Function : Author
Maryam Daneshpour
  • Function : Author
Felix Day
  • Function : Author
Klodian Dhana
  • Function : Author
Ayo Doumatey
  • Function : Author
Nduna Dzimiri
  • Function : Author
Ralf Ewert
  • Function : Author
Janine Felix
Martin Gögele
  • Function : Author
Mark Goodarzi
  • Function : Author
Mariaelisa Graff
  • Function : Author
Einat Granot-Hershkovitz
  • Function : Author
Francine Grodstein
Simonetta Guarrera
  • Function : Author
Kamran Guity
  • Function : Author
Yu Guo
  • Function : Author
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Avner Halevy
  • Function : Author
Mehdi Hedayati
  • Function : Author
David van Heel
  • Function : Author
Makoto Hirata
  • Function : Author
Imo Höfer
  • Function : Author
Chao Agnes Hsiung
  • Function : Author
Jinyan Huang
  • Function : Author
Yi-Jen Hung
  • Function : Author
Pekka Jousilahti
  • Function : Author
Nicola Kerrison
  • Function : Author
Chiea Chuen Khor
Woon-Puay Koh
  • Function : Author
  • PersonId : 1028735
Peter Kraft
Bernhard Krämer
  • Function : Author
Deborah Lawlor
I-Te Lee
  • Function : Author
Wen-Jane Lee
  • Function : Author
Markus Lerch
Liming Li
  • Function : Author
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Jianjun Liu
Marie Loh
  • Function : Author
Stephanie Loomis
  • Function : Author
Yingchang Lu
  • Function : Author
Reedik Mägi
  • Function : Author
Ani Manichaikul
  • Function : Author
Paolo Manunta
  • Function : Author
Christa Meisinger
  • Function : Author
Massimo Mezzavilla
  • Function : Author
Lili Milani
  • Function : Author
Iona Millwood
  • Function : Author
Yukihide Momozawa
  • Function : Author
Hortensia Moreno-Macías
  • Function : Author
Trevor Mori
  • Function : Author
Alanna Morrison
  • Function : Author
Taulant Muka
  • Function : Author
Yoshinori Murakami
  • Function : Author
Alison Murray
Josyf Mychaleckyj
  • Function : Author
Matt Neville
  • Function : Author
Ken K. Ong
  • Function : Author
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Lorena Orozco
  • Function : Author
James Pankow
  • Function : Author
Cristian Pattaro
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Alison Pattie
  • Function : Author
Neil Poulter
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Sarju Ralhan
  • Function : Author
Dabeeru Rao
  • Function : Author
Stephen Rich
  • Function : Author
Antonietta Robino
  • Function : Author
Frank van Rooij
  • Function : Author
Yasaman Saba
  • Function : Author
Charumathi Sabanayagam
  • Function : Author
Maria Sabater-Lleal
  • Function : Author
Cinzia Felicita Sala
  • Function : Author
Kevin Sandow
  • Function : Author
William Scott
  • Function : Author
Bahareh Sedaghati-Khayat
  • Function : Author
Peter Sever
  • Function : Author
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Wayne H-H Sheu
  • Function : Author
Smeeta Shrestha
  • Function : Author
Sharvari Rahul Shukla
  • Function : Author
Timo Tonis Sikka
  • Function : Author
Jai Rup Singh
  • Function : Author
Blair Smith
  • Function : Author
Alice Stanton
  • Function : Author
Leon Straker
  • Function : Author
Morris Swertz
  • Function : Author
  • PersonId : 933291
Adele Taylor
  • Function : Author
Natalie Terzikhan
  • Function : Author
Yih-Chung Tham
  • Function : Author
Annika Tillander
  • Function : Author
Russell Tracy
  • Function : Author
Ioanna Tzoulaki
Simona Vaccargiu
  • Function : Author
Jagadish Vangipurapu
  • Function : Author
Jan Veldink
  • Function : Author
  • PersonId : 911612
Eero Vuoksimaa
  • Function : Author
Salma Wakil
  • Function : Author
Gurpreet Wander
  • Function : Author
Ya Xing Wang
  • Function : Author
Sarah Wild
  • Function : Author
Lingyao Zeng
  • Function : Author
Liang Zhang
  • Function : Author
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Stephan Bakker
Diane Becker
  • Function : Author
Benjamin Lehne
  • Function : Author
David Bennett
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Leonard van den Berg
  • Function : Author
  • PersonId : 890095
Dwaipayan Bharadwaj
  • Function : Author
Lawrence Bielak
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Mike Boehnke
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Jonathan Bradfield
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Shai Carmi
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Mark Caulfield
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David Cesarini
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Giriraj Ratan Chandak
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Marina Ciullo
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  • PersonId : 910154
Marilyn Cornelis
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Ian Deary
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Cornelia M. van Duijn
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  • PersonId : 885418
Jeanette Erdmann
Michele Evans
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Bjarke Feenstra
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Sylvain Foisy
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Yechiel Friedlander
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Clicerio Gonzalez
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Philippe Goyette
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Struan Grant
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Lyn Griffiths
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Ulf Gyllensten
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  • PersonId : 919619
Hakon Hakonarson
Chew-Kiat Heng
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Hagit Hochner
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Magnus Johannesson
Juhani Junttila
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Meena Kumari
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  • PersonId : 919952
Sander van Der Laan
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Matthias Laudes
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Rodney Lea
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Tony Merriman
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Brian Meyer
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Dennis Mook-Kanamori
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Patricia Munroe
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Jeffery O’connell
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Albertine Oldehinkel
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Walter Palmas
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Craig Pennell
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Patricia Peyser
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Tinca Polderman
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John Rioux
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Hester den Ruijter
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Dharambir Sanghera
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Naveed Sattar
Neil Small
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Jennifer Smith
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Nona Sotoodehnia
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E-Shyong Tai
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David-Alexandre Trégouët
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Tiinamaija Tuomi
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Carol Wang
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Babette Zemel
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Alan Zonderman
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Jaspal Kooner
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Ruth J. F. Loos
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Chris Haley
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Tōnu Esko
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Michiaki Kubo
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Abstract

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
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hal-02651737 , version 1 (29-05-2020)

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David J. Clark, Yukinori Okada, Kristjan Moore, Dan Mason, Nicola Pirastu, et al.. Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 2019, 10 (1), pp.4957. ⟨10.1038/s41467-019-12283-6⟩. ⟨hal-02651737⟩