Monocrystalline diamond detector for online monitoring during synchrotron microbeam radiotherapy

Microbeam radiation therapy (MRT) is a radiotherapy technique combining spatial fractionation of the dose distribution on a micrometric scale, X-rays in the 50–500 keV range and dose rates up to 16 × 103 Gy s−1. Nowadays, in vivo dosimetry remains a challenge due to the ultra-high radiation fluxes involved and the need for high-spatial-resolution detectors. The aim here was to develop a striped diamond portal detector enabling online microbeam monitoring during synchrotron MRT treatments. The detector, a 550 µm bulk monocrystalline diamond, is an eight-strip device, of height 3 mm, width 178 µm and with 60 µm spaced strips, surrounded by a guard ring. An eight-channel ASIC circuit for charge integration and digitization has been designed and tested. Characterization tests were performed at the ID17 biomedical beamline of the European Synchrotron Radiation Facility (ESRF). The detector measured direct and attenuated microbeams as well as interbeam fluxes with a precision level of 1%. Tests on phantoms (RW3 and anthropomorphic head phantoms) were performed and compared with simulations. Synchrotron radiation measurements were performed on an RW3 phantom for strips facing a microbeam and for strips facing an interbeam area. A 2% difference between experiments and simulations was found. In more complex geometries, a preliminary study showed that the absolute differences between simulated and recorded transmitted beams were within 2%. Obtained results showed the feasibility of performing MRT portal monitoring using a microstriped diamond detector. Online dosimetric measurements are currently ongoing during clinical veterinary trials at ESRF, and the next 153-strip detector prototype, covering the entire irradiation field, is being finalized at our institution.

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Physique [physics]

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ve5172.pdf (1.17 Mo)

Origine	Publication financée par une institution

Armelle Michetti : Connectez-vous pour contacter le contributeur

https://hal.science/hal-04323368

Soumis le : mercredi 6 décembre 2023-10:07:41

Dernière modification le : vendredi 11 octobre 2024-09:47:48

Dates et versions

hal-04323368 , version 1 (25-09-2023)

hal-04323368 , version 2 (06-12-2023)

Identifiants

HAL Id : hal-04323368 , version 2
DOI : 10.1107/s160057752300752x
INSPIRE : 2730286

Citer

Francesca Di Franco, Nicolas Rosuel, Laurent Gallin-Martel, Marie-Laure Gallin-Martel, Mostafa Ghafooryan-Sangchooli, et al.. Monocrystalline diamond detector for online monitoring during synchrotron microbeam radiotherapy. Journal of Synchrotron Radiation, 2023, 30 (6), pp.1076-1085. ⟨10.1107/s160057752300752x⟩. ⟨hal-04323368v2⟩

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