Article Dans Une Revue Viruses Année : 2024

Emergence of Crimean–Congo Hemorrhagic Fever Virus in Eastern Senegal in 2022

Ousseynou Sene
Moussa Moise Diagne
El Hadji Ndiaye
Safietou Sankhe
Cheikh Loucoubar
Mawlouth Diallo
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Ndongo Dia
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Amadou Alpha Sall
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Ousmane Faye
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Oumar Faye
Diawo Diallo
Gamou Fall
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Résumé

Crimean–Congo hemorrhagic fever (CCHF), the most widespread tick-borne viral human infection, poses a threat to global health. In this study, clinical samples collected through national surveillance systems were screened for acute CCHF virus (CCHFV) infection using RT-PCR and for exposure using ELISA. For any CCHF-positive sample, livestock and tick samples were also collected in the neighborhood of the confirmed case and tested using ELISA and RT-PCR, respectively. Genome sequencing and phylogenetic analyses were also performed on samples with positive RT-PCR results. In Eastern Senegal, two human cases and one Hyalomma tick positive for CCHF were identified and a seroprevalence in livestock ranging from 9.33% to 45.26% was detected. Phylogenetic analyses revealed that the human strain belonged to genotype I based on the available L segment. However, the tick strain showed a reassortant profile, with the L and M segments belonging to genotype I and the S segment belonging to genotype III. Our data also showed that our strains clustered with strains isolated in different countries, including Mauritania. Therefore, our findings confirmed the high genetic variability inside the CCHF genotypes and their introduction to Senegal from other countries. They also indicate an increasing CCHF threat in Senegal and emphasize the need to reinforce surveillance using a one-health approach.

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Virologie
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Dates et versions

hal-04932522 , version 1 (06-02-2025)

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Ousseynou Sene, Samba Niang Sagne, Déthié Ngom, Moussa Moise Diagne, Aminata Badji, et al.. Emergence of Crimean–Congo Hemorrhagic Fever Virus in Eastern Senegal in 2022. Viruses, 2024, 16 (2), pp.315. ⟨10.3390/v16020315⟩. ⟨hal-04932522⟩
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